Protein name:
Vascular endothelial growth factor C (VEGF-C) ;
Alternative:
Vascular endothelial growth factor-related protein (VRP) ;Flt4 ligand (Flt4-L) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer; non-covalent and antiparallel.
Function:
Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
Subcellular Location:
Secreted
Protein Attributes:
50:
MHLLGFFSVA | CSLLAAALLP | GPREAPAAAA | AFESGLDLSD | AEPDAGEATA |
100:
YASKDLEEQL | RSVSSVDELM | TVLYPEYWKM | YKCQLRKGGW | QHNREQANLN |
150:
SRTEETIKFA | AAHYNTEILK | SIDNEWRKTQ | CMPREVCIDV | GKEFGVATNT |
200:
FFKPPCVSVY | RCGGCCNSEG | LQCMNTSTSY | LSKTLFEITV | PLSQGPKPVT |
250:
ISFANHTSCR | CMSKLDVYRQ | VHSIIRRSLP | ATLPQCQAAN | KTCPTNYMWN |
300:
NHICRCLAQE | DFMFSSDAGD | DSTDGFHDIC | GPNKELDEET | CQCVCRAGLR |
350:
PASCGPHKEL | DRNSCQCVCK | NKLFPSQCGA | NREFDENTCQ | CVCKRTCPRN |
400:
QPLNPGKCAC | ECTESPQKCL | LKGKKFHHQT | CSCYRRPCTN | RQKACEPGFS |
419:
YSEEVCRCVP | SYWKRPQMS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
ELISA Kit for Human VEGF-C
ELISA Kit for Human VEGF-C
ELISA Kit for Human VEGF-C
CLIA Kit for Human VEGF-C
CLIA Kit for Human VEGF-C
CLIA Kit for Human VEGF-C
Polyclonal Antibody for Human VEGF-C
Polyclonal Antibody for Human VEGF-C
Polyclonal Antibody for Human VEGF-C
Monoclonal Antibody for Human VEGF-C
Monoclonal Antibody for Human VEGF-C
Monoclonal Antibody for Human VEGF-C
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases."
Joukov V.
,
Pajusola K.
,
Kaipainen A.
,
Chilov D.
,
Lahtinen I.
,
Kukk E.
,
Saksela O.
,
Kalkkinen N.
,
Alitalo K.
EMBO J.15:290-298(1996)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 103-120
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ERRATUM
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Glial tumor .
4.
"Characterization of murine Flt4 ligand/VEGF-C."
Fitz L.J.
,
Morris J.C.
,
Towler P.
,
Long A.
,
Burgess P.
,
Greco R.
,
Wang J.
,
Gassaway R.
,
Nickbarg E.
,
Kovacic S.
,
Ciarletta A.
,
Giannotti J.
,
Finnerty H.
,
Zollner R.
,
Beier D.R.
,
Leak L.V.
,
Turner K.J.
,
Wood C.R.
Oncogene15:613-618(1997)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
5.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Trachea .
6.
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W.
,
Graves T.A.
,
Fulton R.S.
,
Fulton L.A.
,
Pepin K.H.
,
Minx P.
,
Wagner-McPherson C.
,
Layman D.
,
Wylie K.
,
Sekhon M.
,
Becker M.C.
,
Fewell G.A.
,
Delehaunty K.D.
,
Miner T.L.
,
Nash W.E.
,
Kremitzki C.
,
Oddy L.
,
Du H.
,
Sun H.
,
Bradshaw-Cordum H.
,
Ali J.
,
Carter J.
,
Cordes M.
,
Harris A.
,
Isak A.
,
van Brunt A.
,
Nguyen C.
,
Du F.
,
Courtney L.
,
Kalicki J.
,
Ozersky P.
,
Abbott S.
,
Armstrong J.
,
Belter E.A.
,
Caruso L.
,
Cedroni M.
,
Cotton M.
,
Davidson T.
,
Desai A.
,
Elliott G.
,
Erb T.
,
Fronick C.
,
Gaige T.
,
Haakenson W.
,
Haglund K.
,
Holmes A.
,
Harkins R.
,
Kim K.
,
Kruchowski S.S.
,
Strong C.M.
,
Grewal N.
,
Goyea E.
,
Hou S.
,
Levy A.
,
Martinka S.
,
Mead K.
,
McLellan M.D.
,
Meyer R.
,
Randall-Maher J.
,
Tomlinson C.
,
Dauphin-Kohlberg S.
,
Kozlowicz-Reilly A.
,
Shah N.
,
Swearengen-Shahid S.
,
Snider J.
,
Strong J.T.
,
Thompson J.
,
Yoakum M.
,
Leonard S.
,
Pearman C.
,
Trani L.
,
Radionenko M.
,
Waligorski J.E.
,
Wang C.
,
Rock S.M.
,
Tin-Wollam A.-M.
,
Maupin R.
,
Latreille P.
,
Wendl M.C.
,
Yang S.-P.
,
Pohl C.
,
Wallis J.W.
,
Spieth J.
,
Bieri T.A.
,
Berkowicz N.
,
Nelson J.O.
,
Osborne J.
,
Ding L.
,
Meyer R.
,
Sabo A.
,
Shotland Y.
,
Sinha P.
,
Wohldmann P.E.
,
Cook L.L.
,
Hickenbotham M.T.
,
Eldred J.
,
Williams D.
,
Jones T.A.
,
She X.
,
Ciccarelli F.D.
,
Izaurralde E.
,
Taylor J.
,
Schmutz J.
,
Myers R.M.
,
Cox D.R.
,
Huang X.
,
McPherson J.D.
,
Mardis E.R.
,
Clifton S.W.
,
Warren W.C.
,
Chinwalla A.T.
,
Eddy S.R.
,
Marra M.A.
,
Ovcharenko I.
,
Furey T.S.
,
Miller W.
,
Eichler E.E.
,
Bork P.
,
Suyama M.
,
Torrents D.
,
Waterston R.H.
,
Wilson R.K.
more...
Nature434:724-731(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Skin .
tissue :
Urinary bladder .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 32-41; 112-121 AND 228-233;MUTAGENESIS OF ARG-227
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 32-46
11.
"Mutation in vascular endothelial growth factor-C, a ligand for vascular endothelial growth factor receptor-3, is associated with autosomal dominant milroy-like primary lymphedema."
Gordon K.
,
Schulte D.
,
Brice G.
,
Simpson M.A.
,
Roukens M.G.
,
van Impel A.
,
Connell F.
,
Kalidas K.
,
Jeffery S.
,
Mortimer P.S.
,
Mansour S.
,
Schulte-Merker S.
,
Ostergaard P.
Circ. Res.112:956-960(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN LMPH1D
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN LMPH1D
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 112-215 IN COMPLEX WITH KDR;FUNCTION;DISULFIDE BONDS;GLYCOSYLATION AT ASN-175 AND ASN-205;SUBUNIT