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Index > Protein center > VEGFC(Gene name) > Human
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  • VEGFC (Gene name),
  • Vascular endothelial growth factor C (Protein name ),  VEGFC_HUMAN from NCBI database.
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  • Antigen Annotation
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  • Gene name:
    VEGFC;
    Protein name:
    Vascular endothelial growth factor C(VEGF-C);
    Alternative:
    Vascular endothelial growth factor-related protein(VRP);Flt4 ligand(Flt4-L);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer; non-covalent and antiparallel.
    Function:
    Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    419
    Sequence:
    50:
    MHLLGFFSVA | CSLLAAALLP | GPREAPAAAA | AFESGLDLSD | AEPDAGEATA | 
    100:
    YASKDLEEQL | RSVSSVDELM | TVLYPEYWKM | YKCQLRKGGW | QHNREQANLN | 
    150:
    SRTEETIKFA | AAHYNTEILK | SIDNEWRKTQ | CMPREVCIDV | GKEFGVATNT | 
    200:
    FFKPPCVSVY | RCGGCCNSEG | LQCMNTSTSY | LSKTLFEITV | PLSQGPKPVT | 
    250:
    ISFANHTSCR | CMSKLDVYRQ | VHSIIRRSLP | ATLPQCQAAN | KTCPTNYMWN | 
    300:
    NHICRCLAQE | DFMFSSDAGD | DSTDGFHDIC | GPNKELDEET | CQCVCRAGLR | 
    350:
    PASCGPHKEL | DRNSCQCVCK | NKLFPSQCGA | NREFDENTCQ | CVCKRTCPRN | 
    400:
    QPLNPGKCAC | ECTESPQKCL | LKGKKFHHQT | CSCYRRPCTN | RQKACEPGFS | 
    419:
    YSEEVCRCVP | SYWKRPQMS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    MIM:
    Pfam:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human VEGF-C
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    ELISA Kit for Human VEGF-C
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    E0145h
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    ELISA Kit for Human VEGF-C
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    E0145r
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    CLIA Kit for Human VEGF-C
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    U0145h
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    CLIA Kit for Human VEGF-C
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    U0145m
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    CLIA Kit for Human VEGF-C
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    U0145r
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human VEGF-C
    Cat.:
    P0145Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human VEGF-C
    Cat.:
    P0145Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human VEGF-C
    Cat.:
    P0145Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human VEGF-C
    Monoclonal Antibody for Human VEGF-C
    Monoclonal Antibody for Human VEGF-C
    Protein for Human VEGF-C
    Protein for Human VEGF-C
    Protein for Human VEGF-C

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    Precision
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    Linearity
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    References
    1. 1.
      "A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases."
      Joukov V. , Pajusola K. , Kaipainen A. , Chilov D. , Lahtinen I. , Kukk E. , Saksela O. , Kalkkinen N. , Alitalo K.
      EMBO J.15:290-298(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 103-120
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    3. 3.
      "Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4."
      Lee J. , Gray A. , Yuan J. , Luoh S.-M. , Avraham H. , Wood W.I.
      Proc. Natl. Acad. Sci. U.S.A.93:1988-1992(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Glial tumor.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Trachea.
    6. 6.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Skin.
      tissue: Urinary bladder.
    9. 9.
      "Proteolytic processing regulates receptor specificity and activity of VEGF-C."
      Joukov V. , Sorsa T. , Kumar V. , Jeltsch M. , Claesson-Welsh L. , Cao Y. , Saksela O. , Kalkkinen N. , Alitalo K.
      EMBO J.16:3898-3911(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 32-41; 112-121 AND 228-233;MUTAGENESIS OF ARG-227
    10. 10.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 32-46
    11. 11.
      "Mutation in vascular endothelial growth factor-C, a ligand for vascular endothelial growth factor receptor-3, is associated with autosomal dominant milroy-like primary lymphedema."
      Gordon K. , Schulte D. , Brice G. , Simpson M.A. , Roukens M.G. , van Impel A. , Connell F. , Kalidas K. , Jeffery S. , Mortimer P.S. , Mansour S. , Schulte-Merker S. , Ostergaard P.
      Circ. Res.112:956-960(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN LMPH1D
    12. 12.
      "A novel stop mutation in the vascular endothelial growth factor-C gene (VEGFC) results in Milroy-like disease."
      Balboa-Beltran E. , Fernandez-Seara M.J. , Perez-Munuzuri A. , Lago R. , Garcia-Magan C. , Couce M.L. , Sobrino B. , Amigo J. , Carracedo A. , Barros F.
      J. Med. Genet.51:475-478(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN LMPH1D
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 112-215 IN COMPLEX WITH KDR;FUNCTION;DISULFIDE BONDS;GLYCOSYLATION AT ASN-175 AND ASN-205;SUBUNIT
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