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Index > Protein center > FLT4(Gene name) > Human
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  • FLT4 (Gene name),
  • Vascular endothelial growth factor receptor 3 (Protein name ),  VGFR3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    FLT4(VEGFR3);
    Protein name:
    Vascular endothelial growth factor receptor 3(VEGFR-3);
    Alternative:
    Tyrosine-protein kinase receptor FLT4;Fms-like tyrosine kinase 4(FLT-4);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with PTPN14; the interaction is enhanced by stimulation with VEGFC.
    Function:
    Receptor for VEGFC. Has a tyrosine-protein kinase activity.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1298
    Sequence:
    50:
    MQRGAALCLR | LWLCLGLLDG | LVSGYSMTPP | TLNITEESHV | IDTGDSLSIS | 
    100:
    CRGQHPLEWA | WPGAQEAPAT | GDKDSEDTGV | VRDCEGTDAR | PYCKVLLLHE | 
    150:
    VHANDTGSYV | CYYKYIKARI | EGTTAASSYV | FVRDFEQPFI | NKPDTLLVNR | 
    200:
    KDAMWVPCLV | SIPGLNVTLR | SQSSVLWPDG | QEVVWDDRRG | MLVSTPLLHD | 
    250:
    ALYLQCETTW | GDQDFLSNPF | LVHITGNELY | DIQLLPRKSL | ELLVGEKLVL | 
    300:
    NCTVWAEFNS | GVTFDWDYPG | KQAERGKWVP | ERRSQQTHTE | LSSILTIHNV | 
    350:
    SQHDLGSYVC | KANNGIQRFR | ESTEVIVHEN | PFISVEWLKG | PILEATAGDE | 
    400:
    LVKLPVKLAA | YPPPEFQWYK | DGKALSGRHS | PHALVLKEVT | EASTGTYTLA | 
    450:
    LWNSAAGLRR | NISLELVVNV | PPQIHEKEAS | SPSIYSRHSR | QALTCTAYGV | 
    500:
    PLPLSIQWHW | RPWTPCKMFA | QRSLRRRQQQ | DLMPQCRDWR | AVTTQDAVNP | 
    550:
    IESLDTWTEF | VEGKNKTVSK | LVIQNANVSA | MYKCVVSNKV | GQDERLIYFY | 
    600:
    VTTIPDGFTI | ESKPSEELLE | GQPVLLSCQA | DSYKYEHLRW | YRLNLSTLHD | 
    650:
    AHGNPLLLDC | KNVHLFATPL | AASLEEVAPG | ARHATLSLSI | PRVAPEHEGH | 
    700:
    YVCEVQDRRS | HDKHCHKKYL | SVQALEAPRL | TQNLTDLLVN | VSDSLEMQCL | 
    750:
    VAGAHAPSIV | WYKDERLLEE | KSGVDLADSN | QKLSIQRVRE | EDAGRYLCSV | 
    800:
    CNAKGCVNSS | ASVAVEGSED | KGSMEIVILV | GTGVIAVFFW | VLLLLIFCNM | 
    850:
    RRPAHADIKT | GYLSIIMDPG | EVPLEEQCEY | LSYDASQWEF | PRERLHLGRV | 
    900:
    LGYGAFGKVV | EASAFGIHKG | SSCDTVAVKM | LKEGATASEH | RALMSELKIL | 
    950:
    IHIGNHLNVV | NLLGACTKPQ | GPLMVIVEFC | KYGNLSNFLR | AKRDAFSPCA | 
    1000:
    EKSPEQRGRF | RAMVELARLD | RRRPGSSDRV | LFARFSKTEG | GARRASPDQE | 
    1050:
    AEDLWLSPLT | MEDLVCYSFQ | VARGMEFLAS | RKCIHRDLAA | RNILLSESDV | 
    1100:
    VKICDFGLAR | DIYKDPDYVR | KGSARLPLKW | MAPESIFDKV | YTTQSDVWSF | 
    1150:
    GVLLWEIFSL | GASPYPGVQI | NEEFCQRLRD | GTRMRAPELA | TPAIRRIMLN | 
    1200:
    CWSGDPKARP | AFSELVEILG | DLLQGRGLQE | EEEVCMAPRS | SQSSEEGSFS | 
    1250:
    QVSTMALHIA | QADAEDSPPS | LQRHSLAARY | YNWVSFPGCL | ARGAETRGSS | 
    1298:
    RMKTFEEFPM | TPTTYKGSVD | NQTDSGMVLA | SEEFEQIESR | HRQESGFR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    MIM:
    Pfam:
    SMR:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human VEGFR-3
    Cat.:
    E0149h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human VEGFR-3
    Cat.:
    E0149r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human VEGFR-3
    Cat.:
    E0149m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human VEGFR-3
    Cat.:
    U0149h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human VEGFR-3
    Cat.:
    U0149r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human VEGFR-3
    Cat.:
    U0149m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human VEGFR-3
    Cat.:
    P0149Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human VEGFR-3
    Cat.:
    P0149Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human VEGFR-3
    Cat.:
    P0149Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human VEGFR-3
    Monoclonal Antibody for Human VEGFR-3
    Monoclonal Antibody for Human VEGFR-3
    Protein for Human VEGFR-3
    Protein for Human VEGFR-3
    Protein for Human VEGFR-3

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines."
      Pajusola K. , Aprelikova O. , Korhonen J. , Kaipainen A. , Pertovaara L. , Alitalo R. , Alitalo K.
      Cancer Res.52:5738-5743(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    3. 3.
      "Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene."
      Galland F. , Karamysheva A. , Mattei M.-G. , Rosnet O. , Marchetto S. , Birnbaum D.
      Genomics13:475-478(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    4. 4.
      "The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor."
      Galland F. , Karamysheva A. , Pebusque M.-J. , Borg J.-P. , Rottapel R. , Dubreuil P. , Rosnet O. , Birnbaum D.
      Oncogene8:1233-1240(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANTS GLN-890 AND HIS-1146
      tissue: Placenta.
    5. 5.
      "Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4."
      Lee J. , Gray A. , Yuan J. , Luoh S.-M. , Avraham H. , Wood W.I.
      Proc. Natl. Acad. Sci. U.S.A.93:1988-1992(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);INTERACTION WITH VEGFC;PHOSPHORYLATION;FUNCTION IN CELL PROLIFERATION
    6. 6.
      "Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis."
      Jin P. , Zhang J. , Sumariwalla P.F. , Ni I. , Jorgensen B. , Crawford D. , Phillips S. , Feldmann M. , Shepard H.M. , Paleolog E.M.
      Arthritis Res. Ther.10:R73-R73(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);INTERACTION WITH VEGFD;SUBCELLULAR LOCATION
    7. 7.
      Lian Z. , Feitelson M.
      Submitted (2003-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);VARIANTS GLN-890 AND HIS-1146
    8. 8.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT GLN-890
      tissue: Placenta.
    9. 10.
      "FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter."
      Aprelikova O. , Pajusola K. , Partanen J. , Armstrong E. , Alitalo R. , Bailey S.K. , McMahon J. , Wasmuth J. , Huebner K. , Alitalo K.
      Cancer Res.52:746-748(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 761-1190
    10. 11.
      "Two human FLT4 receptor tyrosine kinase isoforms with distinct carboxy terminal tails are produced by alternative processing of primary transcripts."
      Pajusola K. , Aprelikova O. , Armstrong E. , Morris S. , Alitalo K.
      Oncogene8:2931-2937(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1293-1363 (ISOFORM 1);ALTERNATIVE SPLICING
    11. 12.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-39
    12. 13.
      "Biochemical characterization of two isoforms of FLT4, a VEGF receptor-related tyrosine kinase."
      Borg J.P. , deLapeyriere O. , Noguchi T. , Rottapel R. , Dubreuil P. , Birnbaum D.
      Oncogene10:973-984(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;GLYCOSYLATION;SUBCELLULAR LOCATION
    13. 14.
      "Mutation at tyrosine residue 1337 abrogates ligand-dependent transforming capacity of the FLT4 receptor."
      Fournier E. , Dubreuil P. , Birnbaum D. , Borg J.P.
      Oncogene11:921-931(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL PROLIFERATION AND PHOSPHORYLATION OF SHC1;CHARACTERIZATION OF ISOFORM 1 AND ISOFORM 2;INTERACTION WITH SHC1 AND GRB2;AUTOPHOSPHORYLATION;MUTAGENESIS OF TYR-1333; TYR-1337 AND TYR-1363;TISSUE SPECIFICITY
    14. 15.
      "Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)."
      Achen M.G. , Jeltsch M. , Kukk E. , Maekinen T. , Vitali A. , Wilks A.F. , Alitalo K. , Stacker S.A.
      Proc. Natl. Acad. Sci. U.S.A.95:548-553(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH VEGFD;FUNCTION AS VEGFD RECEPTOR;AUTOPHOSPHORYLATION
    15. 16.
      "Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3."
      Makinen T. , Veikkola T. , Mustjoki S. , Karpanen T. , Catimel B. , Nice E.C. , Wise L. , Mercer A. , Kowalski H. , Kerjaschki D. , Stacker S.A. , Achen M.G. , Alitalo K.
      EMBO J.20:4762-4773(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS RECEPTOR FOR VEGFC AND VEGFD IN CELL SURVIVAL; PROLIFERATION AND MIGRATION;FUNCTION IN ACTIVATION OF PROTEIN KINASE C; AKT1; PIK3R1; MAPK1/ERK2 AND MAPK3/ERK1
    16. 17.
      "Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites."
      Dixelius J. , Makinen T. , Wirzenius M. , Karkkainen M.J. , Wernstedt C. , Alitalo K. , Claesson-Welsh L.
      J. Biol. Chem.278:40973-40979(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KDR;CATALYTIC ACTIVITY;AUTOPHOSPHORYLATION;CHARACTERIZATION OF VARIANT LMPH1A PRO-1041;MUTAGENESIS OF LYS-879; TYR-1230; TYR-1231; TYR-1265; TYR-1333; TYR-1337 AND TYR-1363;PHOSPHORYLATION AT TYR-1230; TYR-1231; TYR-1265; TYR-1333; TYR-1337 AND TYR-1363
    17. 18.
      "Heterodimerization with vascular endothelial growth factor receptor-2 (VEGFR-2) is necessary for VEGFR-3 activity."
      Alam A. , Herault J.P. , Barron P. , Favier B. , Fons P. , Delesque-Touchard N. , Senegas I. , Laboudie P. , Bonnin J. , Cassan C. , Savi P. , Ruggeri B. , Carmeliet P. , Bono F. , Herbert J.M.
      Biochem. Biophys. Res. Commun.324:909-915(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN KDR SIGNALING AND IN ANGIOGENESIS;INTERACTION WITH KDR;PHOSPHORYLATION
    18. 19.
      "Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress."
      Wang J.F. , Zhang X. , Groopman J.E.
      J. Biol. Chem.279:27088-27097(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL SURVIVAL;PHOSPHORYLATION IN RESPONSE TO OXIDATIVE STRESS;INTERACTION WITH PIK3R1; SHC1; GRB2; PTPN11 AND PLCG1;ENZYME REGULATION BY MAZ51;CHARACTERIZATION OF VARIANT LMPH1A ARG-857
    19. 20.
      "Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways."
      Salameh A. , Galvagni F. , Bardelli M. , Bussolino F. , Oliviero S.
      Blood106:3423-3431(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIVATION OF AKT1; MAPK1/ERK2; MAPK3/ERK1 AND MAPK8;FUNCTION IN PROMOTING CELL SURVIVAL; PROLIFERATION AND MIGRATION;CHARACTERIZATION OF ISOFORM 1 AND ISOFORM 2;INTERACTION WITH CRK AND GRB2;PHOSPHORYLATION AT TYR-1063; TYR-1068; TYR-1230; TYR-1231 AND TYR-1337;MUTAGENESIS OF TYR-1063; TYR-1068; TYR-1230 AND TYR-1231
    20. 21.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-527
      tissue: Plasma.
    21. 22.
      "Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells."
      Garces C.A. , Kurenova E.V. , Golubovskaya V.M. , Cance W.G.
      Cancer Res.66:1446-1454(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PROMOTING CELL SURVIVAL;INTERACTION WITH PTK2/FAK1;SUBCELLULAR LOCATION
    22. 23.
      "Cooperative and redundant roles of VEGFR-2 and VEGFR-3 signaling in adult lymphangiogenesis."
      Goldman J. , Rutkowski J.M. , Shields J.D. , Pasquier M.C. , Cui Y. , Schmokel H.G. , Willey S. , Hicklin D.J. , Pytowski B. , Swartz M.A.
      FASEB J.21:1003-1012(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN LYMPHANGIOGENESIS
    23. 24.
      "Autocrine loop between vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells."
      Matsuura M. , Onimaru M. , Yonemitsu Y. , Suzuki H. , Nakano T. , Ishibashi H. , Shirasuna K. , Sueishi K.
      Am. J. Pathol.175:1709-1721(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ROLE IN CANCER;FUNCTION AS VEGFC RECEPTOR IN TUMOR LYMPHANGIOGENESIS; CELL PROLIFERATION; CELL SURVIVAL; IN ACTIVATION OF PIK3R1; AKT1 AND MAP KINASES AND IN UP-REGULATION OF VEGFA AND VEGFC EXPRESSION;ENZYME REGULATION;AUTOPHOSPHORYLATION
    24. 25.
      "Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo."
      Kurenova E.V. , Hunt D.L. , He D. , Magis A.T. , Ostrov D.A. , Cance W.G.
      J. Med. Chem.52:4716-4724(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ROLE IN CANCER;INTERACTION WITH PTK2/FAK1
    25. 26.
      "Protein tyrosine phosphatase PTPN14 is a regulator of lymphatic function and choanal development in humans."
      Au A.C. , Hernandez P.A. , Lieber E. , Nadroo A.M. , Shen Y.M. , Kelley K.A. , Gelb B.D. , Diaz G.A.
      Am. J. Hum. Genet.87:436-444(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPN14
    26. 27.
      "Endothelial cell adhesion to the extracellular matrix induces c-Src-dependent VEGFR-3 phosphorylation without the activation of the receptor intrinsic kinase activity."
      Galvagni F. , Pennacchini S. , Salameh A. , Rocchigiani M. , Neri F. , Orlandini M. , Petraglia F. , Gotta S. , Sardone G.L. , Matteucci G. , Terstappen G.C. , Oliviero S.
      Circ. Res.106:1839-1848(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-830; TYR-833; TYR-853; TYR-1063; TYR-1068; TYR-1333 AND TYR-1337;IDENTIFICATION IN A COMPLEX WITH SRC AND ITGB1;MUTAGENESIS OF TYR-1063; TYR-1068 AND TYR-1337;ENZYME REGULATION BY MAZ51;INTERACTION WITH ITGB1; CRK AND SHC1;FUNCTION IN ACTIVATION OF MAPK8 AND IN REGULATION OF ANGIOGENIC SPROUTING;IDENTIFICATION BY MASS SPECTROMETRY
    27. 28.
      "VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts."
      Nilsson I. , Bahram F. , Li X. , Gualandi L. , Koch S. , Jarvius M. , Soderberg O. , Anisimov A. , Kholova I. , Pytowski B. , Baldwin M. , Yla-Herttuala S. , Alitalo K. , Kreuger J. , Claesson-Welsh L.
      EMBO J.29:1377-1388(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KDR;FUNCTION IN MODULATING KDR SIGNALING AND IN ANGIOGENESIS;TISSUE SPECIFICITY
    28. 29.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIVATION OF SIGNALING PATHWAYS;SUBCELLULAR LOCATION
    29. 30.
      "Combined blockade of VEGFR-2 and VEGFR-3 inhibits inflammatory lymphangiogenesis in early and middle stages."
      Yuen D. , Pytowski B. , Chen L.
      Invest. Ophthalmol. Vis. Sci.52:2593-2597(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN LYMPHANGIOGENESIS
    30. 31.
      "VEGF receptor protein-tyrosine kinases: structure and regulation."
      Roskoski R. Jr.
      Biochem. Biophys. Res. Commun.375:287-291(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON STRUCTURE AND FUNCTION
    31. 32.
      "VEGFs and receptors involved in angiogenesis versus lymphangiogenesis."
      Lohela M. , Bry M. , Tammela T. , Alitalo K.
      Curr. Opin. Cell Biol.21:154-165(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ROLE IN LYMPHANGIOGENESIS AND CANCER
    32. 33.
      "Signal transduction by vascular endothelial growth factor receptors."
      Koch S. , Tugues S. , Li X. , Gualandi L. , Claesson-Welsh L.
      Biochem. J.437:169-183(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON LIGAND SPECIFICITY; FUNCTION; STRUCTURE; PHOSPHORYLATION AND SIGNALING
    33. 34.
      "Lymphangiogenesis and cancer metastasis."
      Al-Rawi M.A. , Jiang W.G.
      Front. Biosci.16:723-739(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION IN LYMPHANGIOGENESIS AND ROLE IN CANCER
    34. 35.
      "Hereditary lymphedema: evidence for linkage and genetic heterogeneity."
      Ferrell R.E. , Levinson K.L. , Esman J.H. , Kimak M.A. , Lawrence E.C. , Barmada M.M. , Finegold D.N.
      Hum. Mol. Genet.7:2073-2078(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LMPH1A LEU-1114
    35. 36.
      "Congenital hereditary lymphedema caused by a mutation that inactivates VEGFR3 tyrosine kinase."
      Irrthum A. , Karkkainen M.J. , Devriendt K. , Alitalo K. , Vikkula M.
      Am. J. Hum. Genet.67:295-301(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN LMPH1A;CHARACTERIZATION OF VARIANT LMPH1A ARG-1035
    36. 37.
      "Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema."
      Karkkainen M.J. , Ferrell R.E. , Lawrence E.C. , Kimak M.A. , Levinson K.L. , McTigue M.A. , Alitalo K. , Finegold D.N.
      Nat. Genet.25:153-159(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LMPH1A ARG-857; PRO-1041; PRO-1044 AND LEU-1114;VARIANT SER-641;CHARACTERIZATION OF VARIANTS
    37. 38.
      "Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma."
      Walter J.W. , North P.E. , Waner M. , Mizeracki A. , Blei F. , Walker J.W.T. , Reinisch J.F. , Marchuk D.A.
      Genes Chromosomes Cancer33:295-303(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HCI SER-954 AND SER-1137;VARIANTS ALA-494; GLN-890 AND HIS-1146
    38. 39.
      "Patterns of somatic mutation in human cancer genomes."
      Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
      Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASP-149; CYS-378; ALA-494; SER-527; SER-641; TYR-868; ILE-1010; GLN-1031; ASN-1049; GLN-1075 AND HIS-1146
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