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Index > Protein center > Vkorc1(Gene name) > Rat
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  • Vkorc1 (Gene name),
  • Vitamin K epoxide reductase complex subunit 1 (Protein name ),  VKOR1_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Vkorc1;
    Protein name:
    Vitamin K epoxide reductase complex subunit 1;
    Alternative:
    Vitamin K1 2,3-epoxide reductase subunit 1;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K.
    Subcellular Location:
    Endoplasmic reticulum membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    161
    Sequence:
    50:
    MGTTWRSPGR | LRLALCLAGL | ALSLYALHVK | AARARNEDYR | ALCDVGTAIS | 
    100:
    CSRVFSSRWG | RGFGLVEHVL | GADSILNQSN | SIFGCMFYTI | QLLLGCLRGR | 
    150:
    WASILLILSS | LVSVAGSLYL | AWILFFVLYD | FCIVCITTYA | INAGLMLLSF | 
    161:
    QKVPEHKVKK | P
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Vitamin K epoxide reductase complex subunit 1
    Cat.:
    E0505m
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Vitamin K epoxide reductase complex subunit 1
    Cat.:
    E0505r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Rat Vitamin K epoxide reductase complex subunit 1
    Cat.:
    E0505b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat Vitamin K epoxide reductase complex subunit 1
    Cat.:
    E0505h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Vitamin K epoxide reductase complex subunit 1
    Cat.:
    U0505h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Vitamin K epoxide reductase complex subunit 1
    Cat.:
    U0505m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Vitamin K epoxide reductase complex subunit 1
    Cat.:
    U0505r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Vitamin K epoxide reductase complex subunit 1
    Cat.:
    U0505b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Vitamin K epoxide reductase complex subunit 1
    Polyclonal Antibody for Rat Vitamin K epoxide reductase complex subunit 1
    Cat.:
    P0505Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Vitamin K epoxide reductase complex subunit 1
    Cat.:
    P0505Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Vitamin K epoxide reductase complex subunit 1
    Cat.:
    P0505Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Vitamin K epoxide reductase complex subunit 1
    Monoclonal Antibody for Rat Vitamin K epoxide reductase complex subunit 1
    Monoclonal Antibody for Rat Vitamin K epoxide reductase complex subunit 1
    Monoclonal Antibody for Rat Vitamin K epoxide reductase complex subunit 1
    Protein for Rat Vitamin K epoxide reductase complex subunit 1
    Protein for Rat Vitamin K epoxide reductase complex subunit 1
    Protein for Rat Vitamin K epoxide reductase complex subunit 1
    Protein for Rat Vitamin K epoxide reductase complex subunit 1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2."
      Rost S. , Fregin A. , Ivaskevicius V. , Conzelmann E. , Hoertnagel K. , Pelz H.-J. , Lappegard K. , Seifried E. , Scharrer I. , Tuddenham E.G.D. , Mueller C.R. , Strom T.M. , Oldenburg J.
      Nature427:537-541(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Sprague-Dawley.
      tissue: Liver.
    2. 2.
      "Identification of the gene for vitamin K epoxide reductase."
      Li T. , Chang C.-Y. , Jin D.-Y. , Lin P.-J. , Khvorova A. , Stafford D.W.
      Nature427:541-544(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION
    3. 3.
      "Engineering of a recombinant vitamin K-dependent (gamma)-carboxylation system with enhanced (gamma)-carboxyglutamic acid forming capacity: evidence for a functional CxxC redox center in the system."
      Wajih N. , Sane D.C. , Hutson S.M. , Wallin R.
      J. Biol. Chem.280:10540-10547(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF CYS-132 AND CYS-135;FUNCTION;CATALYTIC ACTIVITY
    4. 4.
      "New insights into the catalytic mechanism of vitamin K epoxide reductase (VKORC1) - The catalytic properties of the major mutations of rVKORC1 explain the biological cost associated to mutations."
      Matagrin B. , Hodroge A. , Montagut-Romans A. , Andru J. , Fourel I. , Besse S. , Benoit E. , Lattard V.
      FEBS Open Bio3:144-150(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;ENZYME REGULATION;SUBCELLULAR LOCATION;CHARACTERIZATION OF VARIANTS GLN-120; GLN-128; CYS-139; PHE-139 AND SER-139
    5. 5.
      "VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy."
      Hammed A. , Matagrin B. , Spohn G. , Prouillac C. , Benoit E. , Lattard V.
      J. Biol. Chem.288:28733-28742(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;CATALYTIC ACTIVITY;ENZYME REGULATION;SUBCELLULAR LOCATION;FUNCTION
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GLN-120; GLN-128; CYS-139; PHE-139 AND SER-139;ENZYME REGULATION;FUNCTION
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