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Index > Protein center > VWF(Gene name) > Dog
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  • VWF (Gene name),
  • von Willebrand factor (Protein name ),  VWF_CANFA from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    VWF(F8VWF);
    Protein name:
    von Willebrand factor(vWF);
    Alternative:

    Organism:
    Dog (Canis familiarisCanis lupus familiaris). 
    General Annotation
    Sub Unit:
    Multimeric. Interacts with F8.
    Function:
    Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
    Subcellular Location:
    Secreted Secreted extracellular space extracellular matrix Localized to storage granules.
    Protein Attributes:
    Sequence length:
    2813
    Sequence:
    50:
    MSPTRLVRVL | LALALILPGK | LCTKGTVGRS | SMARCSLFGG | DFINTFDESM | 
    100:
    YSFAGDCSYL | LAGDCQEHSV | SLIGGFQNGK | RVSLSVYLGE | FFDIHLFVNG | 
    150:
    TMLQGTQSIS | MPYASNGLYL | EAEAGYYKLS | SEAYGFVARI | DGNGNFQVLL | 
    200:
    SDRYFNKTCG | LCGNFNIFAE | DDFRTQEGTL | TSDPYDFANS | WALSSGEQRC | 
    250:
    KRVSPPSSPC | NVSSDEVQQV | LWEQCQLLKS | ASVFARCHPL | VDPEPFVALC | 
    300:
    ERTLCTCVQG | MECPCAVLLE | YARACAQQGI | VLYGWTDHSV | CRPACPAGME | 
    350:
    YKECVSPCTR | TCQSLHVKEV | CQEQCVDGCS | CPEGQLLDEG | HCVGSAECSC | 
    400:
    VHAGQRYPPG | ASLLQDCHTC | ICRNSLWICS | NEECPGECLV | TGQSHFKSFD | 
    450:
    NRYFTFSGVC | HYLLAQDCQD | HTFSVVIETV | QCADDLDAVC | TRSVTVRLPG | 
    500:
    HHNSLVKLKH | GGGVSMDGQD | IQIPLLQGDL | RIQHTVMASV | RLSYGEDLQM | 
    550:
    DWDGRGRLLV | TLSPAYAGKT | CGLCGNYNGN | RGDDFVTPAG | LAEPLVEDFG | 
    600:
    NAWKLLGACE | NLQKQHRDPC | SLNPRQARFA | EEACALLTSS | KFEPCHRAVG | 
    650:
    PQPYVQNCRY | DVCSCSDGRD | CLCSAVANYA | AACARRGVHI | AWREPGFCAL | 
    700:
    SCPQGQVYLQ | CGTPCNMTCR | SLSYPEEDCN | EVCLEGCFCP | PGLYLDERGD | 
    750:
    CVPKAQCPCY | YDGEIFQPED | IFSDHHTMCY | CEDGFMHCTT | SGGLGSLLPN | 
    800:
    PVLSSPRSHR | SKRSLSCRPP | MVKLVCPADN | PRAEGLECAK | TCQNYDLQCM | 
    850:
    STGCVSGCLC | PQGMVRHENR | CVALERCPCF | HQGQEYAPGE | TVKIDCNTCV | 
    900:
    CRDRKWNCTD | HVCDATCSAI | GMAHYLTFDG | LKYLFPGECQ | YVLVQDYCGS | 
    950:
    NPGTFRILVG | NEGCSYPSVK | CKKRVTILVE | GGEIELFDGE | VNVKKPMKDE | 
    1000:
    THFEVVESGQ | YVILLLGKAL | SVVWDHRLSI | SVTLKRTYQE | QVCGLCGNFD | 
    1050:
    GIQNNDFTSS | SLQIEEDPVD | FGNSWKVNPQ | CADTKKVPLD | SSPAVCHNNI | 
    1100:
    MKQTMVDSSC | RILTSDIFQD | CNRLVDPEPF | LDICIYDTCS | CESIGDCTCF | 
    1150:
    CDTIAAYAHV | CAQHGKVVAW | RTATFCPQNC | EERNLHENGY | ECEWRYNSCA | 
    1200:
    PACPITCQHP | EPLACPVQCV | EGCHAHCPPG | KILDELLQTC | IDPEDCPVCE | 
    1250:
    VAGRRLAPGK | KIILNPSDPE | HCQICHCDGV | NFTCQACREP | GSLVVPPTEG | 
    1300:
    PIGSTTSYVE | DTPEPPLHDF | HCSRLLDLVF | LLDGSSKLSE | DEFEVLKVFV | 
    1350:
    VGMMEHLHIS | QKRIRVAVVE | YHDGSHAYIE | LKDRKRPSEL | RRITSQVKYA | 
    1400:
    GSEVASTSEV | LKYTLFQIFG | KIDRPEASRI | ALLLMASQEP | SRLARNLVRY | 
    1450:
    VQGLKKKKVI | VIPVGIGPHA | SLKQIHLIEK | QAPENKAFVF | SGVDELEQRR | 
    1500:
    DEIINYLCDL | APEAPAPTQH | PPMAQVTVGS | ELLGVSSPGP | KRNSMVLDVV | 
    1550:
    FVLEGSDKIG | EANFNKSREF | MEEVIQRMDV | GQDRIHVTVL | QYSYMVTVEY | 
    1600:
    TFSEAQSKGE | VLQQVRDIRY | RGGNRTNTGL | ALQYLSEHSF | SVSQGDREQV | 
    1650:
    PNLVYMVTGN | PASDEIKRMP | GDIQVVPIGV | GPHANVQELE | KIGWPNAPIL | 
    1700:
    IHDFEMLPRE | APDLVLQRCC | SGEGLQIPTL | SPTPDCSQPL | DVVLLLDGSS | 
    1750:
    SIPASYFDEM | KSFTKAFISR | ANIGPRLTQV | SVLQYGSITT | IDVPWNVAYE | 
    1800:
    KVHLLSLVDL | MQQEGGPSQI | GDALSFAVRY | VTSEVHGARP | GASKAVVILV | 
    1850:
    TDVSVDSVDA | AAEAARSNRV | TVFPIGIGDR | YSEAQLSSLA | GPKAGSNMVR | 
    1900:
    LQRIEDLPTV | ATLGNSFFHK | LCSGFDRVCV | DEDGNEKRPG | DVWTLPDQCH | 
    1950:
    TVTCLPDGQT | LLKSHRVNCD | RGPRPSCPNG | QPPLRVEETC | GCRWTCPCVC | 
    2000:
    MGSSTRHIVT | FDGQNFKLTG | SCSYVLFQNK | EQDLEVILHN | GACSPGAKET | 
    2050:
    CMKSIEVKHD | GLSVELHSDM | QMTVNGRLVS | IPYVGGDMEV | NVYGTIMYEV | 
    2100:
    RFNHLGHIFT | FTPQNNEFQL | QLSPRTFASK | TYGLCGICDE | NGANDFILRD | 
    2150:
    GTVTTDWKAL | IQEWTVQQLG | KTCQPVPEEQ | CPVSSSSHCQ | VLLSELFAEC | 
    2200:
    HKVLAPATFY | AMCQPDSCHP | KKVCEAIALY | AHLCRTKGVC | VDWRRANFCA | 
    2250:
    MSCPPSLVYN | HCEHGCPRLC | EGNTSSCGDQ | PSEGCFCPPN | QVMLEGSCVP | 
    2300:
    EEACTQCISE | DGVRHQFLET | WVPAHQPCQI | CTCLSGRKVN | CTLQPCPTAR | 
    2350:
    APTCGPCEVA | RLRQNAEQCC | PEYECVCDLV | SCDLPPVPPC | EDGLQMTLTN | 
    2400:
    PGECRPNFTC | ACRKDECRRE | SPPSCPPHRT | LALRKTQCCD | EYECACNCVN | 
    2450:
    STVSCPLGYL | ASAVTNDCGC | TTTTCFPDKV | CVHRGTIYPV | GQFWEEACDV | 
    2500:
    CTCTDLEDSV | MGLRVAQCSQ | KPCEDNCLSG | FTYVLHEGEC | CGRCLPSACE | 
    2550:
    VVIGSPRGDA | QSHWKNVGSH | WASPDNPCLI | NECVRVKEEV | FVQQRNVSCP | 
    2600:
    QLNVPTCPTG | FQLSCKTSEC | CPTCHCEPLE | ACLLNGTIIG | PGKSLMIDVC | 
    2650:
    TTCRCTVQVG | VISGFKLECR | KTTCEACPLG | YKEEKNQGEC | CGRCLPIACT | 
    2700:
    IQLRGGQIMT | LKRDETIQDG | CDSHFCKVNE | RGEYIWEKRV | TGCPPFDEHK | 
    2750:
    CLAEGGKIMK | IPGTCCDTCE | EPECKDIIAK | LQRVKVGDCK | SEEEVDIHYC | 
    2800:
    EGKCASKAVY | SIHMEDVQDQ | CSCCSPTQTE | PMQVPLRCTN | GSLIYHEILN | 
    2813:
    AMQCRCSPRK | CSK
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    String:
    SMR:
    UniGene:
    Uniprot:
     
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    ELISA Kit for Dog vWF
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    CLIA Kit for Dog vWF
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    CLIA Kit for Dog vWF
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    CLIA Kit for Dog vWF
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    U0833p
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    CLIA Kit for Dog vWF
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    U0833h
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    Polyclonal Antibody for Dog vWF
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    P0833Rb-m
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    Packing:
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    Polyclonal Antibody for Dog vWF
    Polyclonal Antibody for Dog vWF
    Polyclonal Antibody for Dog vWF
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    Polyclonal Antibody for Dog vWF
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    Polyclonal Antibody for Dog vWF
    Monoclonal Antibody for Dog vWF
    Monoclonal Antibody for Dog vWF
    Monoclonal Antibody for Dog vWF
    Monoclonal Antibody for Dog vWF
    Monoclonal Antibody for Dog vWF
    Monoclonal Antibody for Dog vWF
    Protein for Dog vWF
    Protein for Dog vWF
    Protein for Dog vWF
    Protein for Dog vWF
    Protein for Dog vWF
    Protein for Dog vWF

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    Linearity
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    References
    1. 1.
      "Canine vWF cDNA sequence."
      Stoy S.J. , Shibuya H. , Nonneman D.J. , Holzhauer J. , Mohammed I.H. , Johnson G.S.
      Submitted (1996-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "von Willebrand factor storage and multimerization: 2 independent intracellular processes."
      Haberichter S.L. , Fahs S.A. , Montgomery R.R.
      Blood96:1808-1815(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBUNIT;SUBCELLULAR LOCATION
      tissue: Heart.
    3. 3.
      Montgomery R.R. , Fahs S. , Montgomery M.W.
      Submitted (2004-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 55
    4. 4.
      "Mutation causing von Willebrand's disease in Scottish Terriers."
      Venta P.J. , Li J. , Yuzbasiyan-Gurkan V. , Brewer G.J. , Schall W.D.
      J. Vet. Intern. Med.14:10-19(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];DISEASE
      strain: Scottish terrier.
      tissue: Uterus.
    5. 5.
      "The canine von Willebrand factor gene: sequence and expression of a region encoding the glycoprotein Ib/IX binding domain."
      Mancuso D.J. , Christopherson P.A. , Kroner P.A. , Montgomery R.R.
      Submitted (1994-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1234-1669
      tissue: Blood.
    6. 6.
      "von Willebrand factor, platelets and endothelial cell interactions."
      Ruggeri Z.M.
      J. Thromb. Haemost.1:1335-1342(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
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