Gene name:
Wisp1 (Ccn4;Elm1) ;
Protein name:
WNT1-inducible-signaling pathway protein 1 (WISP-1) ;
Alternative:
ELM-1 ;CCN family member 4 ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Downstream regulator in the Wnt/Frizzled-signaling pathway (By similarity). Associated with cell survival. Adheres to skin and melanoma fibroblasts (By similarity). In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan (By similarity). Suppresses tumor growth in vivo.
Subcellular Location:
Secreted
Protein Attributes:
50:
MRWLLPWTLA | AVAVLRVGNI | LATALSPTPT | TMTFTPAPLE | ETTTRPEFCK |
100:
WPCECPQSPP | RCPLGVSLIT | DGCECCKICA | QQLGDNCTEA | AICDPHRGLY |
150:
CDYSGDRPRY | AIGVCAQVVG | VGCVLDGVRY | TNGESFQPNC | RYNCTCIDGT |
200:
VGCTPLCLSP | RPPRLWCRQP | RHVRVPGQCC | EQWVCDDDAR | RPRQTALLDT |
250:
RAFAASGAVE | QRYENCIAYT | SPWSPCSTTC | GLGISTRISN | VNARCWPEQE |
300:
SRLCNLRPCD | VDIQLHIKAG | KKCLAVYQPE | EATNFTLAGC | VSTRTYRPKY |
350:
CGVCTDNRCC | IPYKSKTISV | DFQCPEGPGF | SRQVLWINAC | FCNLSCRNPN |
367:
DIFADLESYP | DFEEIAN
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
ELISA Kit for Mouse WISP-1
ELISA Kit for Mouse WISP-1
ELISA Kit for Mouse WISP-1
CLIA Kit for Mouse WISP-1
CLIA Kit for Mouse WISP-1
CLIA Kit for Mouse WISP-1
Polyclonal Antibody for Mouse WISP-1
Polyclonal Antibody for Mouse WISP-1
Polyclonal Antibody for Mouse WISP-1
Monoclonal Antibody for Mouse WISP-1
Monoclonal Antibody for Mouse WISP-1
Monoclonal Antibody for Mouse WISP-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Expression of the Elm1 gene, a novel gene of the CCN (connective tissue growth factor, Cyr61/Cef10, and neuroblastoma overexpressed gene) family, suppresses In vivo tumor growth and metastasis of K-1735 murine melanoma cells."
Hashimoto Y.
,
Shindo-Okada N.
,
Tani M.
,
Nagamachi Y.
,
Takeuchi K.
,
Shiroishi T.
,
Toma H.
,
Yokota J.
J. Exp. Med.187:289-296(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
HeN .
2.
"WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors."
Pennica D.
,
Swanson T.A.
,
Welsh J.W.
,
Roy M.A.
,
Lawrence D.A.
,
Lee J.
,
Brush J.
,
Taneyhill L.A.
,
Deuel B.
,
Lew M.
,
Watanabe C.
,
Cohen R.L.
,
Melham M.F.
,
Finley G.G.
,
Quirke P.
,
Goddard A.D.
,
Hillan K.J.
,
Gurney A.L.
,
Botstein D.
,
Levine A.J.
more...
Proc. Natl. Acad. Sci. U.S.A.95:14717-14722(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Mammary gland .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C3H/HeN .
strain :
FVB/N .
tissue :
Colon .
tissue :
Mesenchymal cell .