Protein name:
Wilms tumor protein homolog ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with ZNF224 via the zinc-finger region. Interacts with WTAP, FAM123B/WTX and SRY. Interacts with RBM4 (By similarity). Homodimer. Interacts with WTIP. Interacts with actively translating polysomes. Detected in nuclear ribonucleoprotein (mRNP) particles. Interacts with U2AF2. Interacts with HNRNPU via the zinc-finger region. Isoform 1 and isoform 3 interacts with CITED2.
Function:
Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.
Subcellular Location:
Nucleus
Nucleus
nucleolus
Cytoplasm
Nucleus speckle
Shuttles between nucleus and cytoplasm.
Protein Attributes:
50:
MGSDVRDLNA | LLPAVSSLGG | GGGGCGLPVS | GARQWAPVLD | FAPPGASAYG |
100:
SLGGPAPPPA | PPPPPPPPHS | FIKQEPSWGG | AEPHEEQCLS | AFTLHFSGQF |
150:
TGTAGACRYG | PFGPPPPSQA | SSGQARMFPN | APYLPSCLES | QPTIRNQGYS |
200:
TVTFDGAPSY | GHTPSHHAAQ | FPNHSFKHED | PMGQQGSLGE | QQYSVPPPVY |
250:
GCHTPTDSCT | GSQALLLRTP | YSSDNLYQMT | SQLECMTWNQ | MNLGATLKGM |
300:
AAGSSSSVKW | TEGQSNHGIG | YESENHTAPI | LCGAQYRIHT | HGVFRGIQDV |
350:
RRVSGVAPTL | VRSASETSEK | RPFMCAYPGC | NKRYFKLSHL | QMHSRKHTGE |
400:
KPYQCDFKDC | ERRFSRSDQL | KRHQRRHTGV | KPFQCKTCQR | KFSRSDHLKT |
449:
HTRTHTGKTS | EKPFSCRWHS | CQKKFARSDE | LVRHHNMHQR | NMTKLHVAL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Pig
Rat
ELISA Kit for Mouse Wilms tumor protein homolog
ELISA Kit for Mouse Wilms tumor protein homolog
ELISA Kit for Mouse Wilms tumor protein homolog
ELISA Kit for Mouse Wilms tumor protein homolog
CLIA Kit for Mouse Wilms tumor protein homolog
CLIA Kit for Mouse Wilms tumor protein homolog
CLIA Kit for Mouse Wilms tumor protein homolog
CLIA Kit for Mouse Wilms tumor protein homolog
Polyclonal Antibody for Mouse Wilms tumor protein homolog
Polyclonal Antibody for Mouse Wilms tumor protein homolog
Polyclonal Antibody for Mouse Wilms tumor protein homolog
Polyclonal Antibody for Mouse Wilms tumor protein homolog
Monoclonal Antibody for Mouse Wilms tumor protein homolog
Monoclonal Antibody for Mouse Wilms tumor protein homolog
Monoclonal Antibody for Mouse Wilms tumor protein homolog
Monoclonal Antibody for Mouse Wilms tumor protein homolog
Protein for Mouse Wilms tumor protein homolog
Protein for Mouse Wilms tumor protein homolog
Protein for Mouse Wilms tumor protein homolog
Protein for Mouse Wilms tumor protein homolog
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4)
2.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
,
Goodstadt L.
,
Hillier L.W.
,
Zody M.C.
,
Goldstein S.
,
She X.
,
Bult C.J.
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Agarwala R.
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Cherry J.L.
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DiCuccio M.
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Hlavina W.
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Kapustin Y.
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Meric P.
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Maglott D.
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Birtle Z.
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Marques A.C.
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Graves T.
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Zhou S.
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Teague B.
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Potamousis K.
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Churas C.
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Place M.
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Herschleb J.
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Runnheim R.
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Forrest D.
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Amos-Landgraf J.
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Schwartz D.C.
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Cheng Z.
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Lindblad-Toh K.
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Eichler E.E.
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Ponting C.P.
more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE INITIATION;ALTERNATIVE SPLICING (ISOFORMS 5 AND 6)
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH U2AF2
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;RNA-BINDING;INTERACTION WITH POLYSOMES
6.
"A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus."
Srichai M.B.
,
Konieczkowski M.
,
Padiyar A.
,
Konieczkowski D.J.
,
Mukherjee A.
,
Hayden P.S.
,
Kamat S.
,
El-Meanawy M.A.
,
Khan S.
,
Mundel P.
,
Lee S.B.
,
Bruggeman L.A.
,
Schelling J.R.
,
Sedor J.R.
J. Biol. Chem.279:14398-14408(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH WTIP
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;TISSUE SPECIFICITY
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH CITED2;DEVELOPMENTAL STAGE
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HNRNPU;SUBCELLULAR LOCATION
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DEVELOPMENTAL STAGE