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Index > Protein center > SLC30A8(Gene name) > Human
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  • SLC30A8 (Gene name),
  • Zinc transporter 8 (Protein name ),  ZNT8_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SLC30A8(ZNT8);
    Protein name:
    Zinc transporter 8(ZnT-8);
    Alternative:
    Solute carrier family 30 member 8;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein Cytoplasmic vesicle secretory vesicle membrane Multi-pass membrane protein Associated with insulin and glucagon secretory granules.
    Protein Attributes:
    Sequence length:
    369
    Sequence:
    50:
    MEFLERTYLV | NDKAAKMYAF | TLESVELQQK | PVNKDQCPRE | RPEELESGGM | 
    100:
    YHCHSGSKPT | EKGANEYAYA | KWKLCSASAI | CFIFMIAEVV | GGHIAGSLAV | 
    150:
    VTDAAHLLID | LTSFLLSLFS | LWLSSKPPSK | RLTFGWHRAE | ILGALLSILC | 
    200:
    IWVVTGVLVY | LACERLLYPD | YQIQATVMII | VSSCAVAANI | VLTVVLHQRC | 
    250:
    LGHNHKEVQA | NASVRAAFVH | ALGDLFQSIS | VLISALIIYF | KPEYKIADPI | 
    300:
    CTFIFSILVL | ASTITILKDF | SILLMEGVPK | SLNYSGVKEL | ILAVDGVLSV | 
    350:
    HSLHIWSLTM | NQVILSAHVA | TAASRDSQVV | RREIAKALSK | SFTMHSLTIQ | 
    369:
    MESPVDQDPD | CLFCEDPCD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    Pfam:
    SMR:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human ZnT-8
    Cat.:
    E0319h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human ZnT-8
    Cat.:
    E0319r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human ZnT-8
    Cat.:
    E0319m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human ZnT-8
    Cat.:
    U0319m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human ZnT-8
    Cat.:
    U0319h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human ZnT-8
    Cat.:
    U0319r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human ZnT-8
    Cat.:
    P0319Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human ZnT-8
    Cat.:
    P0319Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human ZnT-8
    Cat.:
    P0319Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human ZnT-8
    Monoclonal Antibody for Human ZnT-8
    Monoclonal Antibody for Human ZnT-8
    Protein for Human ZnT-8
    Protein for Human ZnT-8
    Protein for Human ZnT-8

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules."
      Chimienti F. , Devergnas S. , Favier A. , Seve M.
      Diabetes53:2330-2337(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;SUBCELLULAR LOCATION
      tissue: Pancreas.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Kidney.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Amygdala.
      tissue: Brain.
    4. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Lung.
    6. 7.
      "ZnT-8, a pancreatic beta-cell-specific zinc transporter."
      Chimienti F. , Favier A. , Seve M.
      BioMetals18:313-317(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    7. 8.
      "In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion."
      Chimienti F. , Devergnas S. , Pattou F. , Schuit F. , Garcia-Cuenca R. , Vandewalle B. , Kerr-Conte J. , Van Lommel L. , Grunwald D. , Favier A. , Seve M.
      J. Cell Sci.119:4199-4206(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY;FUNCTION
    8. 9.
      "Zinc-transporter genes in human visceral and subcutaneous adipocytes: lean versus obese."
      Smidt K. , Pedersen S.B. , Brock B. , Schmitz O. , Fisker S. , Bendix J. , Wogensen L. , Rungby J.
      Mol. Cell. Endocrinol.264:68-73(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    9. 10.
      "Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9."
      Overbeck S. , Uciechowski P. , Ackland M.L. , Ford D. , Rink L.
      J. Leukoc. Biol.83:368-380(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    10. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TRP-325;INVOLVEMENT IN NONINSULIN-DEPENDENT DIABETES MELLITUS
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