Protein name:
Tight junction protein ZO-1 ;
Alternative:
Zona occludens protein 1 ;Tight junction protein 1 ;Zonula occludens protein 1 ;
Organism:
Dog (Canis familiarisCanis lupus familiaris).
General Annotation
Sub Unit:
Homodimer, and heterodimer with TJP2/ZO-2 and TJP3/ZO-3. with OCLN, CALM, claudins, CGN/cingulin, CXADR, GJA12, GJD3 and UBN1. Interacts (via ZU5 domain) with CDC42BPB and GCOM1. Interacts (via PDZ domain) with GJA1 (By similarity). Interacts with HSPA4.
Function:
The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.
Subcellular Location:
Cell membrane
Peripheral membrane protein
Cytoplasmic side
Cell junction
tight junction
Cell junction
Cell junction
gap junction
Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact. Detected at the leading edge of migrating and wounded cells.
Protein Attributes:
50:
MSARAAAAKN | TAMEETAIWE | QHTVTLHRAP | GFGFGIAISG | GRDNPHFQSG |
100:
ETSIVISDVL | KGGPAEGQLQ | ENDRVAMVNG | VSMDNVEHAF | AVQQLRKSGK |
150:
NAKITIRRKK | KVQIPVSRPD | PEPVSENEDS | YDEEVHDPRS | SRGGLVSRRS |
200:
EKSWARDRSA | SRERSLSPRS | DRRSVASSQP | PKPTKVTLVK | SRKNEEYGLR |
250:
LASHIFVKEI | SQDSLAARDG | NIQEGDVVLK | INGTVTENMS | LTDAKTLIER |
300:
SKGKLKMVVQ | RDERATLLNV | PDLSDSIHSA | NASERDDISE | IQSLASDHSG |
350:
RSHDRPPRHS | RSRSPDQRSE | PSDHSRHSPQ | QPSSGSLRSR | EEERISKPGA |
400:
VSTPVKHADD | HTHKTVEEVV | VERNEKQAPS | LPEPKPVYAQ | VGQPDVDLPV |
450:
SPSDGVLPNS | THEDGILRPS | MKLVKFRKGD | SVGLRLAGGN | DVGIFVAGVL |
500:
EDSPAAKEGL | EEGDQILRVN | NVDFTNIIRE | EAVLFLLDLP | KGEEVTILAQ |
550:
KKKDVYRRIV | ESDVGDSFYI | RTHFEYEKES | PYGLSFNKGE | VFRVVDTLYN |
600:
GKLGSWLAIR | IGKNHKEVER | GIIPNKNRAE | QLASVQYTLP | KTAGGDRADF |
650:
WRFRGLRSSK | RNLRKSREDL | SAQPVQTKFP | AYERVVLREA | GFLRPVTIFG |
700:
PIADVAREKL | AREEPDIYQI | AKSEPRDAGT | DQRSSGIIRL | HTIKQIIDQD |
750:
KHALLDVTPN | AVDRLNYAQW | YPIVVFLNPD | SKQGVKTMRM | RLCPESRKSA |
800:
RKLYERSHKL | RKNNHHLFTT | TINLNSMNDG | WYGALKEAIQ | QQQNQLVWVS |
850:
EGKADGATSD | DLDLHDDRLS | YLSAPGSEYS | MYSTDSRHTS | DYEDTDTEGG |
900:
AYTDQELDET | LNDEVGTPPE | SAITRSSEPV | REDSSGMHHE | NQTYPPYSPQ |
950:
AQPQPIHRID | SPGFKTASQQ | KAEASSPVPY | LSPETNPASS | TSAVNHNVTL |
1000:
TNVRLEGPTP | APSTSYSPQA | DSLRTPSTEA | AHIMLRDQEP | SLPSHVEPAK |
1050:
VYRKDPYPEE | MMRQNHVLKQ | PAVGHPGQRP | DKEPNLSYES | QPPYVEKQAN |
1100:
RDLEQPTYRY | DSSSYTDQFS | RNYDHRLRYE | ERIPTYEEQW | SYYDDKQPYQ |
1150:
PRPSLDNQHP | RDLDSRQHPE | ESSERGSYPR | FEEPAPLSYD | SRPRYDQPPR |
1200:
TSTLRHEEQP | TPGYDMHNRY | RPEAQSYSSA | GPKASEPKQY | FDQYPRSYEQ |
1250:
VPSQGFSSKA | GHYEPLHGAA | VVPPLIPASQ | HKPEVLPSNT | KPLPPPPTLT |
1300:
EEEEDPAMKP | QSVLTRVKMF | ENKRSASLEN | KKDENHTAGF | KPPEVASKPP |
1350:
GAPIIGPKPT | PQNQFSEHDK | TLYRIPEPQK | PQMKPPEDIV | RSNHYDPEED |
1400:
EEYYRKQLSY | FDRRSFENKP | STHIPAGHLS | EPAKPVHSQN | QTNFSSYSSK |
1450:
GKSPEADAPD | RSFGEKRYEP | VQATPPPPPL | PSQYAQPSQP | GTSSSLALHT |
1500:
HAKGAHGEGN | SISLDFQNSL | VSKPDPPPSQ | NKPATFRPPN | REDTVQSTFY |
1550:
PQKSFPDKAP | VNGAEQTQKT | VTPAYNRFTP | KPYTSSARPF | ERKFESPKFN |
1600:
HNLLPSETAH | KPDLSSKAPA | SPKTLAKAHS | RAQPPEFDSG | VETFSIHADK |
1650:
PKYQMNNLST | VPKAIPVSPS | AVEEDEDEDG | HTVVATARGV | FNNNGGVLSS |
1700:
IETGVSIIIP | QGAIPEGVEQ | EIYFKVCRDN | SILPPLDKEK | GETLLSPLVM |
1750:
CGPHGLKFLK | PVELRLPHCA | SMTPDGWSFA | LKSSDSSSGD | PKTWQNKCLP |
1769:
GDPNYLVGAN | CVSVLIDHF
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Dog
Mouse
ELISA Kit for Dog Tight junction protein ZO-1
ELISA Kit for Dog Tight junction protein ZO-1
ELISA Kit for Dog Tight junction protein ZO-1
CLIA Kit for Dog Tight junction protein ZO-1
CLIA Kit for Dog Tight junction protein ZO-1
CLIA Kit for Dog Tight junction protein ZO-1
Polyclonal Antibody for Dog Tight junction protein ZO-1
Polyclonal Antibody for Dog Tight junction protein ZO-1
Polyclonal Antibody for Dog Tight junction protein ZO-1
Monoclonal Antibody for Dog Tight junction protein ZO-1
Monoclonal Antibody for Dog Tight junction protein ZO-1
Monoclonal Antibody for Dog Tight junction protein ZO-1
Protein for Dog Tight junction protein ZO-1
Protein for Dog Tight junction protein ZO-1
Protein for Dog Tight junction protein ZO-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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References
1.
"Molecular characterization of the tight junction protein ZO-1 in MDCK cells."
Gonzalez-Mariscal L.
,
Islas S.
,
Contreras R.G.
,
Garcia-Villegas M.R.
,
Betanzos A.
,
Vega J.
,
Diaz-Quinonez A.
,
Martin-Orozco N.
,
Ortiz-Navarrete V.
,
Cereijido M.
,
Valdes J.
Exp. Cell Res.248:97-109(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Cocker spaniel .
tissue :
Kidney .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HSPA4