TJP1 ELISA Kit for Human(Homo sapiens) | EIAab.comTJP1 ELISA Kit for Human(Homo sapiens)

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TJP1 (Gene name),

Tight junction protein ZO-1 (Protein name ), ZO1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

TJP1(ZO1);

Protein name:

Tight junction protein ZO-1;

Alternative:

Zona occludens protein 1;Tight junction protein 1;Zonula occludens protein 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with HSPA4 and KIRREL1 (By similarity). Homodimer, and heterodimer with TJP2/ZO-2 and TJP3/ZO-3. Interacts with OCLN, CALM, claudins, CGN/cingulin, CXADR, GJA12, GJD3 and UBN1. Interacts (via ZU5 domain) with CDC42BPB and GCOM1. Interacts (via PDZ domain) with GJA1.

Function:

The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.

Subcellular Location:

Cell membrane Peripheral membrane protein Cytoplasmic side Cell junction tight junction Cell junction Cell junction gap junction Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact. Detected at the leading edge of migrating and wounded cells.

Protein Attributes:

Sequence length:

1748

Sequence:

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1650:

1700:

1748:

GPHGLKFLKP | VELRLPHCDP | KTWQNKCLPG | DPNYLVGANC | VSVLIDHF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00625

MIM:

601009

UniGene:

Hs.743990

STRING:

9606.ENSP00000281537

SMR:

Q07157

KEGG:

hsa:7082

String:

Q07157

UniGene:

Hs.510833

Uniprot:

Q07157

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ELISA Kit for Human Tight junction protein ZO-1

Cat.:

E9600h

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96T

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ELISA Kit for Human Tight junction protein ZO-1

Cat.:

E9600d

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96T

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ELISA Kit for Human Tight junction protein ZO-1

Cat.:

E9600m

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Manual:

Looking for manual.

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Packing:

96T

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CLIA Kit for Human Tight junction protein ZO-1

Cat.:

U9600h

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MSDS:

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Packing:

96T

CLIA Kit for Human Tight junction protein ZO-1

Cat.:

U9600m

Price:

Please sign in first.

MSDS:

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Packing:

96T

CLIA Kit for Human Tight junction protein ZO-1

Cat.:

U9600d

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Tight junction protein ZO-1

Cat.:

P9600Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Tight junction protein ZO-1

Cat.:

P9600Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Tight junction protein ZO-1

Protein for Human Tight junction protein ZO-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions."
Willott E. , Balda M.S. , Fanning A.S. , Jameson B. , van Itallie C. , Anderson J.M.
Proc. Natl. Acad. Sci. U.S.A.90:7834-7838(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT VAL-790
tissue: Liver.
2.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG);VARIANT VAL-790
tissue: Uterus.
3.

NIEHS SNPs program
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS SER-471; VAL-790; LEU-930; ARG-1110; ALA-1347 AND SER-1605
4.

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C. , Garber M. , Sharpe T. , Young S.K. , Rowen L. , O'Neill K. , Whittaker C.A. , Kamal M. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Kodira C.D. , Madan A. , Qin S. , Yang X. , Abbasi N. , Abouelleil A. , more...
Nature440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
6.

"The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction."
Cohen C.J. , Shieh J.T.C. , Pickles R.J. , Okegawa T. , Hsieh J.-T. , Bergelson J.M.
Proc. Natl. Acad. Sci. U.S.A.98:15191-15196(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH CXADR
7.

"Evidence for a functional interaction between cingulin and ZO-1 in cultured cells."
D'Atri F. , Nadalutti F. , Citi S.
J. Biol. Chem.277:27757-27764(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CGN
8.

"Molecular cloning, functional expression, and tissue distribution of a novel human gap junction-forming protein, connexin-31.9. Interaction with zona occludens protein-1."
Nielsen P.A. , Beahm D.L. , Giepmans B.N. , Baruch A. , Hall J.E. , Kumar N.M.
J. Biol. Chem.277:38272-38283(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GJD3
9.

"Connexin47, connexin29 and connexin32 co-expression in oligodendrocytes and Cx47 association with zonula occludens-1 (ZO-1) in mouse brain."
Li X. , Ionescu A.V. , Lynn B.D. , Lu S. , Kamasawa N. , Morita M. , Davidson K.G.V. , Yasumura T. , Rash J.E. , Nagy J.I.
Neuroscience126:611-630(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GJA12
10.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-337 AND SER-1366;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
11.

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125 AND SER-912;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
12.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125; SER-277; SER-329; SER-617; SER-912; SER-968 AND SER-1545;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
13.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.

"Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos)."
Aho S. , Lupo J. , Coly P.-A. , Sabine A. , Castellazzi M. , Morand P. , Sergeant A. , Manet E. , Boyer V. , Gruffat H.
Biol. Cell101:319-334(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBN1
15.

"Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells."
Sallee J.L. , Burridge K.
J. Biol. Chem.284:14997-15006(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;DEPHOSPHORYLATION BY PTPRJ
16.

"Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo."
Seeger T.S. , Frank D. , Rohr C. , Will R. , Just S. , Grund C. , Lyon R. , Luedde M. , Koegl M. , Sheikh F. , Rottbauer W. , Franke W.W. , Katus H.A. , Olson E.N. , Frey N.
Circ. Res.106:880-890(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MYZAP
17.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-329; SER-337; SER-353; SER-617; SER-968; SER-1366 AND SER-1617;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-912 (ISOFORM SHORT);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
18.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.

"Multi-tasking role of the mechanosensing protein Ankrd2 in the signaling network of striated muscle."
Belgrano A. , Rakicevic L. , Mittempergher L. , Campanaro S. , Martinelli V.C. , Mouly V. , Valle G. , Kojic S. , Faulkner G.
PLoS ONE6:E25519-E25519(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ANKRD2
20.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125; SER-175; SER-178; SER-179; THR-185; SER-297; SER-300; SER-329; SER-334; SER-337; SER-617; SER-622 AND SER-1366;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-912 (ISOFORM SHORT);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
21.

"Comparative structural analysis of the erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity."
Appleton B.A. , Zhang Y. , Wu P. , Yin J.P. , Hunziker W. , Skelton N.J. , Sidhu S.S. , Wiesmann C.
J. Biol. Chem.281:22312-22320(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 18-110;SUBUNIT
22.

"Domain swapping within PDZ2 is responsible for dimerization of ZO proteins."
Fanning A.S. , Lye M.F. , Anderson J.M. , Lavie A.
J. Biol. Chem.282:37710-37716(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 185-264;SUBUNIT
23.

"Domain-swapped dimerization of ZO-1 PDZ2 generates specific and regulatory connexin43-binding sites."
Chen J. , Pan L. , Wei Z. , Zhao Y. , Zhang M.
EMBO J.27:2113-2123(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 182-273 IN COMPLEX WITH GJA1 PEPTIDE;SUBUNIT;MUTAGENESIS OF ARG-201 AND LYS-209;SUBCELLULAR LOCATION;INTERACTION WITH GJA1
24.

"Insights into regulated ligand binding sites from the structure of ZO-1 Src homology 3-guanylate kinase module."
Lye M.F. , Fanning A.S. , Su Y. , Anderson J.M. , Lavie A.
J. Biol. Chem.285:13907-13917(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 516-803;INTERACTION WITH CALM
25.

"Cdc42-dependent formation of the ZO-1/MRCKbeta complex at the leading edge controls cell migration."
Huo L. , Wen W. , Wang R. , Kam C. , Xia J. , Feng W. , Zhang M.
EMBO J.30:665-678(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1631-1748 OF MUTANT 1699-MET-CYS-1700 IN COMPLEX WITH MYZAP;FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF 1699-MET-CYS-1700 AND PHE-1748;INTERACTION WITH MYZAP AND CDC42BPB
26.

"Solution structure of the second PDZ domain of Zonula Occludens 1."
Ji P. , Yang G. , Zhang J. , Wu J. , Chen Z. , Gong Q. , Wu J. , Shi Y.
Proteins79:1342-1346(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 185-264

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