Gene name:
TJP2 (X104;ZO2) ;
Protein name:
Tight junction protein ZO-2 ;
Alternative:
Zona occludens protein 2 ;Tight junction protein 2 ;Zonula occludens protein 2 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer, and heterodimer with ZO1. Interacts with occludin, SAFB and UBN1. Interaction with SAFB occurs in the nucleus. Interacts with SCRIB.
Function:
Plays a role in tight junctions and adherens junctions.
Subcellular Location:
Cell junction
adherens junction
Cell membrane
Peripheral membrane protein
Cytoplasmic side
Cell junction
tight junction
Nucleus
Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures.
Protein Attributes:
50:
MPVRGDRGFP | PRRELSGWLR | APGMEELIWE | QYTVTLQKDS | KRGFGIAVSG |
100:
GRDNPHFENG | ETSIVISDVL | PGGPADGLLQ | ENDRVVMVNG | TPMEDVLHSF |
150:
AVQQLRKSGK | VAAIVVKRPR | KVQVAALQAS | PPLDQDDRAF | EVMDEFDGRS |
200:
FRSGYSERSR | LNSHGGRSRS | WEDSPERGRP | HERARSRERD | LSRDRSRGRS |
250:
LERGLDQDHA | RTRDRSRGRS | LERGLDHDFG | PSRDRDRDRS | RGRSIDQDYE |
300:
RAYHRAYDPD | YERAYSPEYR | RGARHDARSR | GPRSRSREHP | HSRSPSPEPR |
350:
GRPGPIGVLL | MKSRANEEYG | LRLGSQIFVK | EMTRTGLATK | DGNLHEGDII |
400:
LKINGTVTEN | MSLTDARKLI | EKSRGKLQLV | VLRDSQQTLI | NIPSLNDSDS |
450:
EIEDISEIES | NRSFSPEERR | HQYSDYDYHS | SSEKLKERPS | SREDTPSRLS |
500:
RMGATPTPFK | STGDIAGTVV | PETNKEPRYQ | EDPPAPQPKA | APRTFLRPSP |
550:
EDEAIYGPNT | KMVRFKKGDS | VGLRLAGGND | VGIFVAGIQE | GTSAEQEGLQ |
600:
EGDQILKVNT | QDFRGLVRED | AVLYLLEIPK | GEMVTILAQS | RADVYRDILA |
650:
CGRGDSFFIR | SHFECEKETP | QSLAFTRGEV | FRVVDTLYDG | KLGNWLAVRI |
700:
GNELEKGLIP | NKSRAEQMAS | VQNAQRDNAG | DRADFWRMRG | QRSGVKKNLR |
750:
KSREDLTAVV | SVSTKFPAYE | RVLLREAGFK | RPVVLFGPIA | DIAMEKLANE |
800:
LPDWFQTAKT | EPKDAGSEKS | TGVVRLNTVR | QIIEQDKHAL | LDVTPKAVDL |
850:
LNYTQWFPIV | IFFNPDSRQG | VKTMRQRLNP | TSNKSSRKLF | DQANKLKKTC |
900:
AHLFTATINL | NSANDSWFGS | LKDTIQHQQG | EAVWVSEGKM | EGMDDDPEDR |
950:
MSYLTAMGAD | YLSCDSRLIS | DFEDTDGEGG | AYTDNELDEP | AEEPLVSSIT |
1000:
RSSEPVQHEE | SIRKPSPEPR | AQMRRAASSD | QLRDNSPPPA | FKPEPPKAKT |
1050:
QNKEESYDFS | KSYEYKSNPS | AVAGNETPGA | STKGYPPPVA | AKPTFGRSIL |
1100:
KPSTPIPPQE | GEEVGESSEE | QDNAPKSVLG | KVKIFEKMDH | KARLQRMQEL |
1150:
QEAQNARIEI | AQKHPDIYAV | PIKTHKPDPG | TPQHTSSRPP | EPQKAPSRPY |
1190:
QDTRGSYGSD | AEEEEYRQQL | SEHSKRGYYG | QSARYRDTEL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Dog
Human
ELISA Kit for Human Tight junction protein ZO-2
ELISA Kit for Human Tight junction protein ZO-2
ELISA Kit for Human Tight junction protein ZO-2
CLIA Kit for Human Tight junction protein ZO-2
CLIA Kit for Human Tight junction protein ZO-2
CLIA Kit for Human Tight junction protein ZO-2
Polyclonal Antibody for Human Tight junction protein ZO-2
Polyclonal Antibody for Human Tight junction protein ZO-2
Polyclonal Antibody for Human Tight junction protein ZO-2
Monoclonal Antibody for Human Tight junction protein ZO-2
Monoclonal Antibody for Human Tight junction protein ZO-2
Monoclonal Antibody for Human Tight junction protein ZO-2
Protein for Human Tight junction protein ZO-2
Protein for Human Tight junction protein ZO-2
Protein for Human Tight junction protein ZO-2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A1);VARIANTS GLU-482; ASN-822 AND ASP-829
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Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS A1; C1; A2 AND C2);TISSUE SPECIFICITY;ALTERNATIVE PROMOTER USAGE;VARIANT GLU-482
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A3);VARIANT GLU-482
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 7);VARIANTS GLU-482 AND ILE-668
tissue :
Brain .
tissue :
Testis .
5.
"DNA sequence and analysis of human chromosome 9."
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[
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[
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A1)
tissue :
Testis .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1-166 (ISOFORMS A1/A2/A3);NUCLEOTIDE SEQUENCE [MRNA] OF 1-119 (ISOFORMS C1/C2)
tissue :
Pancreas .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PARTIAL NUCLEOTIDE SEQUENCE (ISOFORMS A1 AND C1);ALTERNATIVE PROMOTER USAGE
tissue :
Pancreas .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1047-1167
tissue :
Aortic smooth muscle .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SCRIB
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-174; SER-244; SER-702; SER-966 AND SER-986;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Platelet .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-170; SER-174; SER-244; SER-266; SER-400; THR-455; SER-920; THR-925; THR-933; SER-978; SER-986; SER-1067; SER-1068; THR-1131 AND SER-1159;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH UBN1
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244 AND SER-1159;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
18.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
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Vermeulen M.
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Santamaria A.
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Kumar C.
,
Miller M.L.
,
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Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130; SER-170; SER-174; SER-244; SER-920; THR-925; SER-986 AND SER-1159;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
19.
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130; SER-153; SER-168; SER-174; SER-200; SER-220; SER-244; SER-430; SER-978; SER-986; SER-1067; SER-1068; SER-1147 AND SER-1159;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.
"Mutations in TJP2 cause progressive cholestatic liver disease."
Sambrotta M.
,
Strautnieks S.
,
Papouli E.
,
Rushton P.
,
Clark B.E.
,
Parry D.A.
,
Logan C.V.
,
Newbury L.J.
,
Kamath B.M.
,
Ling S.
,
Grammatikopoulos T.
,
Wagner B.E.
,
Magee J.C.
,
Sokol R.J.
,
Mieli-Vergani G.
,
Smith J.D.
,
Johnson C.A.
,
McClean P.
,
Simpson M.A.
,
Knisely A.S.
,
Bull L.N.
,
Thompson R.J.
more...
Nat. Genet.46:326-328(2014)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : INVOLVEMENT IN PFIC4
21.
"Domain-swapped dimerization of the second PDZ domain of ZO2 may provide a structural basis for the polymerization of claudins."
Wu J.
,
Yang Y.
,
Zhang J.
,
Ji P.
,
Du W.
,
Jiang P.
,
Xie D.
,
Huang H.
,
Wu M.
,
Zhang G.
,
Wu J.
,
Shi Y.
J. Biol. Chem.282:35988-35999(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : STRUCTURE BY NMR OF 306-385;SUBUNIT
22.
"Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT."
Carlton V.E.H.
,
Harris B.Z.
,
Puffenberger E.G.
,
Batta A.K.
,
Knisely A.S.
,
Robinson D.L.
,
Strauss K.A.
,
Shneider B.L.
,
Lim W.A.
,
Salen G.
,
Morton D.H.
,
Bull L.N.
Nat. Genet.34:91-96(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANT FHCA ALA-48
23.
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Cited for : VARIANT [LARGE SCALE ANALYSIS] GLU-482;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]