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Index > Protein center > TJP2(Gene name) > Human
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  • TJP2 (Gene name),
  • Tight junction protein ZO-2 (Protein name ),  ZO2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TJP2(X104;ZO2);
    Protein name:
    Tight junction protein ZO-2;
    Alternative:
    Zona occludens protein 2;Tight junction protein 2;Zonula occludens protein 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer, and heterodimer with ZO1. Interacts with occludin, SAFB and UBN1. Interaction with SAFB occurs in the nucleus. Interacts with SCRIB.
    Function:
    Plays a role in tight junctions and adherens junctions.
    Subcellular Location:
    Cell junction adherens junction Cell membrane Peripheral membrane protein Cytoplasmic side Cell junction tight junction Nucleus Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures.
    Protein Attributes:
    Sequence length:
    1190
    Sequence:
    50:
    MPVRGDRGFP | PRRELSGWLR | APGMEELIWE | QYTVTLQKDS | KRGFGIAVSG | 
    100:
    GRDNPHFENG | ETSIVISDVL | PGGPADGLLQ | ENDRVVMVNG | TPMEDVLHSF | 
    150:
    AVQQLRKSGK | VAAIVVKRPR | KVQVAALQAS | PPLDQDDRAF | EVMDEFDGRS | 
    200:
    FRSGYSERSR | LNSHGGRSRS | WEDSPERGRP | HERARSRERD | LSRDRSRGRS | 
    250:
    LERGLDQDHA | RTRDRSRGRS | LERGLDHDFG | PSRDRDRDRS | RGRSIDQDYE | 
    300:
    RAYHRAYDPD | YERAYSPEYR | RGARHDARSR | GPRSRSREHP | HSRSPSPEPR | 
    350:
    GRPGPIGVLL | MKSRANEEYG | LRLGSQIFVK | EMTRTGLATK | DGNLHEGDII | 
    400:
    LKINGTVTEN | MSLTDARKLI | EKSRGKLQLV | VLRDSQQTLI | NIPSLNDSDS | 
    450:
    EIEDISEIES | NRSFSPEERR | HQYSDYDYHS | SSEKLKERPS | SREDTPSRLS | 
    500:
    RMGATPTPFK | STGDIAGTVV | PETNKEPRYQ | EDPPAPQPKA | APRTFLRPSP | 
    550:
    EDEAIYGPNT | KMVRFKKGDS | VGLRLAGGND | VGIFVAGIQE | GTSAEQEGLQ | 
    600:
    EGDQILKVNT | QDFRGLVRED | AVLYLLEIPK | GEMVTILAQS | RADVYRDILA | 
    650:
    CGRGDSFFIR | SHFECEKETP | QSLAFTRGEV | FRVVDTLYDG | KLGNWLAVRI | 
    700:
    GNELEKGLIP | NKSRAEQMAS | VQNAQRDNAG | DRADFWRMRG | QRSGVKKNLR | 
    750:
    KSREDLTAVV | SVSTKFPAYE | RVLLREAGFK | RPVVLFGPIA | DIAMEKLANE | 
    800:
    LPDWFQTAKT | EPKDAGSEKS | TGVVRLNTVR | QIIEQDKHAL | LDVTPKAVDL | 
    850:
    LNYTQWFPIV | IFFNPDSRQG | VKTMRQRLNP | TSNKSSRKLF | DQANKLKKTC | 
    900:
    AHLFTATINL | NSANDSWFGS | LKDTIQHQQG | EAVWVSEGKM | EGMDDDPEDR | 
    950:
    MSYLTAMGAD | YLSCDSRLIS | DFEDTDGEGG | AYTDNELDEP | AEEPLVSSIT | 
    1000:
    RSSEPVQHEE | SIRKPSPEPR | AQMRRAASSD | QLRDNSPPPA | FKPEPPKAKT | 
    1050:
    QNKEESYDFS | KSYEYKSNPS | AVAGNETPGA | STKGYPPPVA | AKPTFGRSIL | 
    1100:
    KPSTPIPPQE | GEEVGESSEE | QDNAPKSVLG | KVKIFEKMDH | KARLQRMQEL | 
    1150:
    QEAQNARIEI | AQKHPDIYAV | PIKTHKPDPG | TPQHTSSRPP | EPQKAPSRPY | 
    1190:
    QDTRGSYGSD | AEEEEYRQQL | SEHSKRGYYG | QSARYRDTEL | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    MIM:
    String:
    UniGene:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Tight junction protein ZO-2
    ELISA Kit for Human Tight junction protein ZO-2
    ELISA Kit for Human Tight junction protein ZO-2
    CLIA Kit for Human Tight junction protein ZO-2
    CLIA Kit for Human Tight junction protein ZO-2
    CLIA Kit for Human Tight junction protein ZO-2
    Polyclonal Antibody for Human Tight junction protein ZO-2
    Polyclonal Antibody for Human Tight junction protein ZO-2
    Polyclonal Antibody for Human Tight junction protein ZO-2
    Monoclonal Antibody for Human Tight junction protein ZO-2
    Monoclonal Antibody for Human Tight junction protein ZO-2
    Monoclonal Antibody for Human Tight junction protein ZO-2
    Protein for Human Tight junction protein ZO-2
    Protein for Human Tight junction protein ZO-2
    Protein for Human Tight junction protein ZO-2

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    Precision
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    Recovery
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    Linearity
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    References
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      "The Friedreich ataxia region: characterization of two novel genes and reduction of the critical region to 300 kb."
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A1);VARIANTS GLU-482; ASN-822 AND ASP-829
      tissue: Brain.
    2. 2.
      "Organization and expression of the human zo-2 gene (tjp-2) in normal and neoplastic tissues."
      Chlenski A. , Ketels K.V. , Korovaitseva G.I. , Talamonti M.S. , Oyasu R. , Scarpelli D.G.
      Biochim. Biophys. Acta1493:319-324(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS A1; C1; A2 AND C2);TISSUE SPECIFICITY;ALTERNATIVE PROMOTER USAGE;VARIANT GLU-482
      tissue: Pancreas.
    3. 3.
      "LIM protein KyoT2 interacts with human tight junction protein ZO-2-i3."
      Yan H.H. , Rong L. , Qiang S. , Jian W. , Peng Z. , Hua H. , Hui Z.W.
      Submitted (2002-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A3);VARIANT GLU-482
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 7);VARIANTS GLU-482 AND ILE-668
      tissue: Brain.
      tissue: Testis.
    5. 5.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A1)
      tissue: Testis.
    7. 7.
      "Tight junction protein ZO-2 is differentially expressed in normal pancreatic ducts compared to human pancreatic adenocarcinoma."
      Chlenski A. , Ketels K.V. , Tsao M.-S. , Talamonti M.S. , Anderson M.R. , Oyasu R. , Scarpelli D.G.
      Int. J. Cancer82:137-144(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-166 (ISOFORMS A1/A2/A3);NUCLEOTIDE SEQUENCE [MRNA] OF 1-119 (ISOFORMS C1/C2)
      tissue: Pancreas.
    8. 8.
      "Zo-2 gene alternative promoters in normal and neoplastic human pancreatic duct cells."
      Chlenski A. , Ketels K.V. , Engeriser J.L. , Talamonti M.S. , Tsao M.-S. , Koutnikova H. , Oyasu R. , Scarpelli D.G.
      Int. J. Cancer83:349-358(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE (ISOFORMS A1 AND C1);ALTERNATIVE PROMOTER USAGE
      tissue: Pancreas.
    9. 9.
      Adams L.D. , Werny I. , Schwartz S.M.
      Submitted (1997-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1047-1167
      tissue: Aortic smooth muscle.
    10. 10.
      "hScrib interacts with ZO-2 at the cell-cell junctions of epithelial cells."
      Metais J.-Y. , Navarro C. , Santoni M.-J. , Audebert S. , Borg J.-P.
      FEBS Lett.579:3725-3730(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SCRIB
    11. 11.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-174; SER-244; SER-702; SER-966 AND SER-986;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Platelet.
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-170; SER-174; SER-244; SER-266; SER-400; THR-455; SER-920; THR-925; THR-933; SER-978; SER-986; SER-1067; SER-1068; THR-1131 AND SER-1159;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
      Han G. , Ye M. , Zhou H. , Jiang X. , Feng S. , Jiang X. , Tian R. , Wan D. , Zou H. , Gu J.
      Proteomics8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    15. 15.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    16. 16.
      "Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos)."
      Aho S. , Lupo J. , Coly P.-A. , Sabine A. , Castellazzi M. , Morand P. , Sergeant A. , Manet E. , Boyer V. , Gruffat H.
      Biol. Cell101:319-334(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBN1
    17. 17.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244 AND SER-1159;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    18. 18.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130; SER-170; SER-174; SER-244; SER-920; THR-925; SER-986 AND SER-1159;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    19. 19.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130; SER-153; SER-168; SER-174; SER-200; SER-220; SER-244; SER-430; SER-978; SER-986; SER-1067; SER-1068; SER-1147 AND SER-1159;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN PFIC4
    21. 21.
      "Domain-swapped dimerization of the second PDZ domain of ZO2 may provide a structural basis for the polymerization of claudins."
      Wu J. , Yang Y. , Zhang J. , Ji P. , Du W. , Jiang P. , Xie D. , Huang H. , Wu M. , Zhang G. , Wu J. , Shi Y.
      J. Biol. Chem.282:35988-35999(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 306-385;SUBUNIT
    22. 22.
      "Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT."
      Carlton V.E.H. , Harris B.Z. , Puffenberger E.G. , Batta A.K. , Knisely A.S. , Robinson D.L. , Strauss K.A. , Shneider B.L. , Lim W.A. , Salen G. , Morton D.H. , Bull L.N.
      Nat. Genet.34:91-96(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FHCA ALA-48
    23. 23.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-482;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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