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Index > Protein center > ZRANB1(Gene name) > Human
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  • ZRANB1 (Gene name),
  • Ubiquitin thioesterase ZRANB1 (Protein name ),  ZRAN1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ZRANB1(TRABID);
    Protein name:
    Ubiquitin thioesterase ZRANB1;
    Alternative:
    hTrabid;Zinc finger Ran-binding domain-containing protein 1(hTrabid);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with APC and TRAF6.
    Function:
    Positive regulator of the Wnt signaling pathway that specifically cleaves 'Lys-63'-linked ubiquitin chains. Acts by deubiquitinating APC protein, a negative regulator of Wnt-mediated transcription. May also modulate TNF-alpha signaling.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    708
    Sequence:
    50:
    MSERGIKWAC | EYCTYENWPS | AIKCTMCRAQ | RPSGTIITED | PFKSGSSDVG | 
    100:
    RDWDPSSTEG | GSSPLICPDS | SARPRVKSSY | SMENANKWSC | HMCTYLNWPR | 
    150:
    AIRCTQCLSQ | RRTRSPTESP | QSSGSGSRPV | AFSVDPCEEY | NDRNKLNTRT | 
    200:
    QHWTCSVCTY | ENWAKAKRCV | VCDHPRPNNI | EAIELAETEE | ASSIINEQDR | 
    250:
    ARWRGSCSSG | NSQRRSPPAT | KRDSEVKMDF | QRIELAGAVG | SKEELEVDFK | 
    300:
    KLKQIKNRMK | KTDWLFLNAC | VGVVEGDLAA | IEAYKSSGGD | IARQLTADEV | 
    350:
    RLLNRPSAFD | VGYTLVHLAI | RFQRQDMLAI | LLTEVSQQAA | KCIPAMVCPE | 
    400:
    LTEQIRREIA | ASLHQRKGDF | ACYFLTDLVT | FTLPADIEDL | PPTVQEKLFD | 
    450:
    EVLDRDVQKE | LEEESPIINW | SLELATRLDS | RLYALWNRTA | GDCLLDSVLQ | 
    500:
    ATWGIYDKDS | VLRKALHDSL | HDCSHWFYTR | WKDWESWYSQ | SFGLHFSLRE | 
    550:
    EQWQEDWAFI | LSLASQPGAS | LEQTHIFVLA | HILRRPIIVY | GVKYYKSFRG | 
    600:
    ETLGYTRFQG | VYLPLLWEQS | FCWKSPIALG | YTRGHFSALV | AMENDGYGNR | 
    650:
    GAGANLNTDD | DVTITFLPLV | DSERKLLHVH | FLSAQELGNE | EQQEKLLREW | 
    700:
    LDCCVTEGGV | LVAMQKSSRR | RNHPLVTQMV | EKWLDRYRQI | RPCTSLSDGE | 
    708:
    EDEDDEDE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    MIM:
    KEGG:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ubiquitin thioesterase ZRANB1
    ELISA Kit for Human Ubiquitin thioesterase ZRANB1
    ELISA Kit for Human Ubiquitin thioesterase ZRANB1
    CLIA Kit for Human Ubiquitin thioesterase ZRANB1
    CLIA Kit for Human Ubiquitin thioesterase ZRANB1
    CLIA Kit for Human Ubiquitin thioesterase ZRANB1
    Polyclonal Antibody for Human Ubiquitin thioesterase ZRANB1
    Polyclonal Antibody for Human Ubiquitin thioesterase ZRANB1
    Polyclonal Antibody for Human Ubiquitin thioesterase ZRANB1
    Monoclonal Antibody for Human Ubiquitin thioesterase ZRANB1
    Monoclonal Antibody for Human Ubiquitin thioesterase ZRANB1
    Monoclonal Antibody for Human Ubiquitin thioesterase ZRANB1
    Protein for Human Ubiquitin thioesterase ZRANB1
    Protein for Human Ubiquitin thioesterase ZRANB1
    Protein for Human Ubiquitin thioesterase ZRANB1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Isolation and characterization of two novel A20-like proteins."
      Evans P.C. , Taylor E.R. , Coadwell J. , Heyninck K. , Beyaert R. , Kilshaw P.J.
      Biochem. J.357:617-623(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH TRAF6
      tissue: Umbilical vein endothelial cell.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Testis.
    3. 3.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 151-708
      tissue: Melanoma.
    6. 6.
      "Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains."
      Tran H. , Hamada F. , Schwarz-Romond T. , Bienz M.
      Genes Dev.22:528-542(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH APC;DOMAIN;MUTAGENESIS OF CYS-10; 14-THR-TYR-15; CYS-90; 94-THR-TYR-95; CYS-155; 159-THR-TYR-160 AND CYS-443
    7. 7.
      "Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration."
      Bai S.W. , Herrera-Abreu M.T. , Rohn J.L. , Racine V. , Tajadura V. , Suryavanshi N. , Bechtel S. , Wiemann S. , Baum B. , Ridley A.J.
      BMC Biol.9:54-54(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    8. 8.
      "OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis."
      Mevissen T.E. , Hospenthal M.K. , Geurink P.P. , Elliott P.R. , Akutsu M. , Arnaudo N. , Ekkebus R. , Kulathu Y. , Wauer T. , El Oualid F. , Freund S.M. , Ovaa H. , Komander D.
      Cell154:169-184(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY
    9. 9.
      "An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains."
      Licchesi J.D. , Mieszczanek J. , Mevissen T.E. , Rutherford T.J. , Akutsu M. , Virdee S. , El Oualid F. , Chin J.W. , Ovaa H. , Bienz M. , Komander D.
      Nat. Struct. Mol. Biol.19:62-71(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.23 ANGSTROMS) OF 245-697;FUNCTION;LINKAGE SPECIFICITY;ACTIVE SITE;DOMAIN ANK REPEATS
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