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LHPP intimate association with hyperthyroidism

Posted by star on 2018-05-30 23:05:40
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    Enhanced expression of LHPP, also known as Phospholysine phosphohistidine inorganic pyrophosphate phosphatase, is closely associated with hyperthyroidism, while its decreased expression is related to neoplastic states. But, in current study, the mechanistic basis of the regulation of LHPP expression in the thyroid remains unclear.

    LHPP is expressed only in thyrocytes, but not in stromal endothelial cells, fibroblasts, and adipocytes within various lesions of the thyroid. In addition, LHPP is more prominently displayed in hyperfunctional state of the thyroid, e.g., Graves’ disease and autonomously functional thyroid nodule (AFTN) than others. Tumor cell types of follicular adenoma and papillary carcinoma show decreased expression of LHPP. Especially, papillary carcinoma undergoes both local invasion and lymphatic metastases. Thus, LHPP may not be linked to invasive and metastatic ability of the neoplastic cell type. This also suggests that the functions of the tumor cells may be different from those of normal thyrocytes in terms of thyroid hormone synthesis.

    This suggests that LHPP could be a new functional predictor in the thyroid. In addition, nuclear expression of LHPP in thyrocytes of Graves’ disease and AFTN is lost in culture. Thus, it seems likely that the determination of mechanisms of nuclear translocalization of LHPP opens way to address the regulatory mechanisms of hyperthyroidism.

    Wuhan EIAab Science Co., Ltd has developed LHPP protein, antibody and ELISA kit. Welcome scientific research workers to choose and purchase.




 

   A new study published in the May 21 issue of the British Medical Journal Heart shows that eating an egg a day on average for healthy adults may help reduce the risks of cardiovascular disease compared to not eating or eating fewer eggs.

    All along, some people think that the high cholesterol content of eggs will increase the risk of coronary heart disease or stroke, and they are afraid to eat eggs. In fact, eggs also contain high-quality proteins, vitamins, and bioactive substances such as phospholipids and carotenoids.

    In order to study the impact of eating eggs on health, researchers in China and the United Kingdom used data collected from the "China Chronic Disease Prospective Research Project," which is still ongoing, and studied adults aged 30 to 79 years who were recruited 2004 to 2008. The researchers selected data from approximately 460,000 people who did not have a history of cancer, cardiovascular disease, and diabetes, and kept track of their frequency of eating eggs as well as morbidity and mortality.

    A preliminary analysis found that people who eat one egg each day have a 26% lower risk of developing hemorrhagic stroke (cerebral hemorrhage) than those who do not eat or rarely eat eggs, and a 18% reduction in the risk of death from cardiovascular disease.

    The researchers said that this shows that the amount of eggs eaten is significantly associated with a lower risk of cardiovascular disease, which provides a scientific basis for recommending dietary guidelines for the intake of eggs by healthy adults. However, the researchers also stress that this study is an observational study, and therefore cannot draw a clear conclusion of cause and effect.



New anticancer protein - LHPP

Posted by star on 2018-05-29 18:47:50
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    Professor Michael n. Hall of the university of Basel, Switzerland, and his team have discovered a new cancer-fighting protein, LHPP, that prevents uncontrolled proliferation of hepatocellular carcinoma cells.They reported that LHPP could also be a biomarker for diagnosis and prognosis of liver cancer.The results of the study were published in the journal Nature on March 21, 2018. The study was titled "protein histidine phosphatase LHPP is a tumor suppressor".

    Liver tumors are produced by mutant cells that grow and are not controlled.Cancer-fighting proteins, known as tumor suppressor proteins, prevent uncontrolled cell growth.Now, the hall's team has discovered a new tumor suppressor proteins LHPP, their research confirmed that the loss of LHPP promoted the growth of tumor and reduce the survival of cancer patients, LHPP may as a prognostic biomarker.

    By activating the mTOR signal in the liver, the researchers developed a mouse liver cancer model.They analyzed more than 4,000 proteins and compared them with healthy tissue and tumor tissue.One of the most popular enzymes is histidine phosphatase LHPP.LHPP exists in healthy tissue and does not exist in tumor tissues.The researchers reintroduced genetic information encoded by LHPP to prevent tumor formation and maintenance of liver function.Similar to the mouse model, researchers like Hindupur also observed a significant decrease in LHPP levels in liver cancer patients, and the severity and life expectancy of the disease were related to LHPP level.Due to the lack of this tumor suppressor protein, cancer patients died on average two years ago.LHPP is a biomarker for tumor classification.As a phosphatase, LHPP removes phosphate groups that bind to histidine proteins.Like all amino acids, histidine is an essential component of ......

Born in June to August is more susceptible to cardiovascular disease

Posted by star on 2018-05-29 18:43:43
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    A biological study recently was published in the Scientific Report states that American scientists screened 129,778 dogs for cardiovascular data. They found that dogs born in June to August were more susceptible to cardiovascular disease than dogs born in other months. The dog's heart is considered to be an effective physiological model of the human heart because they both have extremely similar cardiovascular systems.

    Cardiovascular and cerebrovascular disease refers to ischaemia or hemorrhage in the heart, brain and systemic tissues due to hyperlipidemia, blood viscosity, atherosclerosis, and hypertension, which is currently ranks first in all causes of death.

    The researchers analyzed cardiovascular data from 253 different breeds of 129,778 dogs and found that in breeds without genetic susceptibility to cardiovascular disease, dogs born in June to August have higher risk of vascular disease than dogs were born in other months. However, the birth season does not appear to affect dogs that are already genetically susceptible to cardiovascular disease.

    The research team emphasized that because the relationship between birth season and cardiovascular disease is more pronounced in dogs without genetic susceptibility, this effect is likely due to environmental factors. One of these factors may be selective breeding, in which dogs that are susceptible to cardiovascular disease are more closely "monitored" than dogs that are less susceptible to disease. Researchers believe that there may also be genetic factors that make dogs less susceptible to cardiovascular disease are more vulnerable to the adverse environmental effects associated with the birth season.

    Dogs and humans have similar cardiovascular systems, and because the......

NAFLD-HCC treatment for new target - SQLE

Posted by star on 2018-05-28 18:34:00
Hits:34

    Non-alcoholic fatty liver (NAFLD) has become the main cause of hepatocellular carcinoma (HCC) in developed countries. Patients with NAFLD related HCC had a shorter survival period and a later stage of tumor staging, and the possibility of liver transplantation was lower. But the mechanisms that led to its formation are largely unknown and targeted therapies are currently unavailable.

    RNA sequencing analysis of NAFLD-HCC samples showed that squalene epoxidase (SQLE) was the highest abnormal metabolic gene in patients with NAFLD-HCC. The expression of Sqle gene in mouse liver cells has accelerated the development of high fat and high cholesterol diet induced liver cancer. SQLE plays its carcinogenic role through its metabolites, cholesterol esters and nicotinamide adenine dinucleotide phosphate (NADP+). Increased SQLE expression promotes biosynthesis of cholesterol esters, thereby inducing the growth of NAFLD-HCC cells. SQLE increase NADP + / NADPH (NADP +) ratio, triggered a series of events, including oxidative stress induced DNA methyltransferase 3A (DNMT3A) express, DNMT3A mediated epigenetic inhibit PTEN, and AKT-activation of mTOR (mammalian target of rapamycin).

    In human NAFLD-HCC and HCC, SQLE is overexpressed, and its expression is related to poor prognosis. Terbinafine, the us food and drug administration approved antifungal drugs targeting SQLE, significantly inhibited the NAFLD - HCC and HCC cells induced by SQL NAFLD - HCC cell growth, and in the xenograft model and SQLE transgenic mice suppress tumor development.By inhibiting tumor growth through terbinafine, and lowering the concentration of cholesterol esters, the expression of PTEN was restored, and AKT-mTOR was suppressed, which was consistent with the blocking of SQLE function.In general, we established SQLE as the oncogen......

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