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    SE (also called squalene epoxidase or squalene monooxygenase, SM EC 1.14.99.7) is a 64 kDa enzyme codified by Human SQLE gene. It was first detected in rat liver microsomes, in 1969. SE is located in the endoplasmic reticulum of cells, and although ubiquitous, it is present at very low levels in most non-cholesterolemic mammalian tissues, while it is highly expressed in liver, neural tissue, in the gut, and in the skin.

    Oncogenic alteration of the cholesterol synthesis pathway is a recognized mechanism of metabolic adaptation. SE is a rate-limiting enzyme leading to effective inhibition of cholesterol synthesis when blocked: if the step of squalene oxygenation catalyzed by SE is influenced, the synthesis of sterols and cell membrane or even cell growth will be subsequently affected. In addition to this transcriptional regulation, the rapid shutdown of cholesterol synthesis requires post-transcriptional control: SE is directly regulated by cholesterol itself which results in its degradation via the ubiquitin-proteasome system.

    High expression of SQLE has been implicated in lethal prostate cancer pathogenesis, in colorectal cancer, and in squamous lung cancer occurrence and development. In that context, SQLE has been suggested as a new molecular marker predicting poor prognosis. Finally, a recent study suggests the involvement of SE in leukemia. In particular, approximately threefold-higher SQLE transcript levels were observed in the daunorubicin-resistant leukemia CEM/R2 cell line.

    Wuhan EIAab Science Co., Ltd has developed squalene epoxidase protein, antibody. Welcome scientific research workers to choose and purchase.



Novel compounds inhibit cervical cancer

Posted by star on 2018-05-31 18:54:23
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    Japanese researchers recently reported that they had invented a compound that inhibits cervical cancer and that they have confirmed efficacy in animal experiments. The next plan is to conduct clinical trials during the year.

    Human papillomavirus (HPV) is the main cause of cervical cancer. Researchers at Kyoto University and other institutions in Japan recently published a paper in the American academic journal Clinical Cancer Research. They said that they invented a compound called FIT-039. In experiments using cervical epithelial cells in patients with cervical cancer, Compounds can inhibit viral proliferation.

    The team conducted an animal experiment, transplanted human cervical cancer cells into experimental mice, and fed with this compound. It was found that it also inhibited cancer cell proliferation in mice. After 3 weeks, compared with the control group, the proliferation rate of the experimental mice fed with the drug was reduced by 30%, and no side effects occurred.

    Researchers believe that this compound may be a new option for preventing cervical cancer. In the future, they will also confirm their impact on reproductive function. They plan to conduct clinical trials on early cervical cancer patients in 2018.



LHPP intimate association with hyperthyroidism

Posted by star on 2018-05-30 23:05:40
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    Enhanced expression of LHPP, also known as Phospholysine phosphohistidine inorganic pyrophosphate phosphatase, is closely associated with hyperthyroidism, while its decreased expression is related to neoplastic states. But, in current study, the mechanistic basis of the regulation of LHPP expression in the thyroid remains unclear.

    LHPP is expressed only in thyrocytes, but not in stromal endothelial cells, fibroblasts, and adipocytes within various lesions of the thyroid. In addition, LHPP is more prominently displayed in hyperfunctional state of the thyroid, e.g., Graves’ disease and autonomously functional thyroid nodule (AFTN) than others. Tumor cell types of follicular adenoma and papillary carcinoma show decreased expression of LHPP. Especially, papillary carcinoma undergoes both local invasion and lymphatic metastases. Thus, LHPP may not be linked to invasive and metastatic ability of the neoplastic cell type. This also suggests that the functions of the tumor cells may be different from those of normal thyrocytes in terms of thyroid hormone synthesis.

    This suggests that LHPP could be a new functional predictor in the thyroid. In addition, nuclear expression of LHPP in thyrocytes of Graves’ disease and AFTN is lost in culture. Thus, it seems likely that the determination of mechanisms of nuclear translocalization of LHPP opens way to address the regulatory mechanisms of hyperthyroidism.

    Wuhan EIAab Science Co., Ltd has developed LHPP protein, antibody and ELISA kit. Welcome scientific research workers to choose and purchase.




 

   A new study published in the May 21 issue of the British Medical Journal Heart shows that eating an egg a day on average for healthy adults may help reduce the risks of cardiovascular disease compared to not eating or eating fewer eggs.

    All along, some people think that the high cholesterol content of eggs will increase the risk of coronary heart disease or stroke, and they are afraid to eat eggs. In fact, eggs also contain high-quality proteins, vitamins, and bioactive substances such as phospholipids and carotenoids.

    In order to study the impact of eating eggs on health, researchers in China and the United Kingdom used data collected from the "China Chronic Disease Prospective Research Project," which is still ongoing, and studied adults aged 30 to 79 years who were recruited 2004 to 2008. The researchers selected data from approximately 460,000 people who did not have a history of cancer, cardiovascular disease, and diabetes, and kept track of their frequency of eating eggs as well as morbidity and mortality.

    A preliminary analysis found that people who eat one egg each day have a 26% lower risk of developing hemorrhagic stroke (cerebral hemorrhage) than those who do not eat or rarely eat eggs, and a 18% reduction in the risk of death from cardiovascular disease.

    The researchers said that this shows that the amount of eggs eaten is significantly associated with a lower risk of cardiovascular disease, which provides a scientific basis for recommending dietary guidelines for the intake of eggs by healthy adults. However, the researchers also stress that this study is an observational study, and therefore cannot draw a clear conclusion of cause and effect.



New anticancer protein - LHPP

Posted by star on 2018-05-29 18:47:50
Hits:36

   

    Professor Michael n. Hall of the university of Basel, Switzerland, and his team have discovered a new cancer-fighting protein, LHPP, that prevents uncontrolled proliferation of hepatocellular carcinoma cells.They reported that LHPP could also be a biomarker for diagnosis and prognosis of liver cancer.The results of the study were published in the journal Nature on March 21, 2018. The study was titled "protein histidine phosphatase LHPP is a tumor suppressor".

    Liver tumors are produced by mutant cells that grow and are not controlled.Cancer-fighting proteins, known as tumor suppressor proteins, prevent uncontrolled cell growth.Now, the hall's team has discovered a new tumor suppressor proteins LHPP, their research confirmed that the loss of LHPP promoted the growth of tumor and reduce the survival of cancer patients, LHPP may as a prognostic biomarker.

    By activating the mTOR signal in the liver, the researchers developed a mouse liver cancer model.They analyzed more than 4,000 proteins and compared them with healthy tissue and tumor tissue.One of the most popular enzymes is histidine phosphatase LHPP.LHPP exists in healthy tissue and does not exist in tumor tissues.The researchers reintroduced genetic information encoded by LHPP to prevent tumor formation and maintenance of liver function.Similar to the mouse model, researchers like Hindupur also observed a significant decrease in LHPP levels in liver cancer patients, and the severity and life expectancy of the disease were related to LHPP level.Due to the lack of this tumor suppressor protein, cancer patients died on average two years ago.LHPP is a biomarker for tumor classification.As a phosphatase, LHPP removes phosphate groups that bind to histidine proteins.Like all amino acids, histidine is an essential component of ......

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