Also known as HIF - 1 - alpha, HIF 1 - alpha HIF1A human protein-coding genes. Two alternative transcripts encoding different subtypes were confirmed. HIF1 heterodimeric basic helix - loop - helix structure composed of Hif1a, alpha subunit (protein), and aryl hydrocarbon receptor nuclear transport protein (Arnt), beta subunits.
Encoding protein HIF1 bHLH - PAS transcription factors exist in mammalian cells in low oxygen concentration.It plays an important role in cell, the system's response to hypoxia. this is a kind of oxygen induced factor, a family, including Hif1a, Hif2a and Hif3a
The transcription factor induced by hypoxia HIF1 activate autophagy, alienation of the pathways involved in maintaining cellular homeostasis. The research results show that HIF1A, all kinds of stimulation, is an important intermediary EDN2 mRNA expression.Results may explain HIF1A - dependent gene levels (EDN2 and VEGF) in developing CL.
The rich HIF-1alpha (its subsequent activities) is regulated transcriptionally in an NF-κB-dependent manner. In addition, coordinate activities of the prolyl hydroxylase to keep the right balance of HIF - 1 alpha stage after protein translation.