Aquaporin-1 is a widely expressed water channel, whose physiological function has been most thoroughly characterized in the kidney.It forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
It is found in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas.
Aquaporin-1 is assotiate multiple tumor angiogenesis and metastasis, for example , the protein level is up-regualaion in breaste cancer, ovarian cancer, prostate cancer, bladder cancer.
Many diseases, such as cardiovascular disease and some neurological diseases are due to membrane function disorder . scientists research cell membrane channel which could look for specific reasons to develope appropriate drugs.
Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein.
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References
1，Towne J E, Harrod K S, Krane C M, et al. Decreased expression of aquaporin (AQP) 1 and AQP5 in mouse lung after acute viral infection[J]. American journal of respiratory cell and molecular biology, 2000, 22(1): 34-44.
2，Mobasheri A, Marples D. Expression of the AQP-1 water channel in normal human tissues: a semiquantitative study using tissue microarray technology[J]. American Journal of Physiology-Cell Physiology, 2004, 286(3): C529-C537.
3，Herrera M, Garvin J L. Novel role of AQP-1 in NO-dependent vasorelaxation[J]. American Journal of Physiology-Renal Physiology, 2007, 292(5): F1443-F1451.
4，Clapp C, de la Escalera G M. Aquaporin-1: a novel promoter of tumor angiogenesis[J]. Trends in Endocrinology & Metabolism, 2006, 17(1): 1-2.
5，Li J, Xu M, Fan Q, et al. Tanshinone IIA ameliorates seawater exposure-induced lung injury by inhibiting aquaporins (AQP) 1 and AQP5 expression in lung[J]. Respiratory physiology & neurobiology, 2011, 176(1): 39-49.
6，Endeward V, Cartron J P, Ripoche P, et al. RhAG protein of the Rhesus complex is a CO2 channel in the human red cell membrane[J]. The FASEB Journal, 2008, 22(1): 64-73.
