[Sign in] [Register]   

EIAab logo

EIAab news detail, please contact if you have any questions about online orders and payment.
Microbes potentially influence the efficacy of cancer therapies
Update time:2017-09-18 23:51:35   【 Font: Large  Medium Small



      A study published 4 days ago on Science was shown that bacteria could potentially mediate tumor resistance to the chemotherapeutic drug gemcitabine, which was commonly used for the treatment of pancreatic ductal adenocarcinomas (PDAC).






      In the research, Geller et al. showed that Gammaproteobacteria expressed cytidine deaminase (CDDL), which could metabolize gemcitabine (2’, 2’-difluorodeoxycytidine) into its inactive form, 2’, 2’ -difluorodeoxyuridine. It had been confirmed in a colon cancer mouse model that the tumors became resistant to gemcitabine. However, gemcitabine resistance would be eliminated by the mixture of the antibiotic ciprofloxacin.




      These results suggested that the efficacy of an existing therapy for PDAC might be improved as the cooperation with antibiotics.




DOI: 10.1126/science.aah5043


by EIAab organize the information.
Hot Genes
ALCAM ACE KSR2 ASPRO C19orf80 Gdf5 Trap1a Atf2
Top Searches
Ubiquitin ELISA Ubiquitin-protein ligase metalloproteinase Asprosin TRAP1A Tumor necrosis vitamin d
Why choose EIAAB
Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more
Further Information
About us Protein center Bank account Distributors Terms & Conditions Career

Copyright & copy www.eiaab.com2006-2016 All Rights Reserved    EIAab