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A new mechanism of tumor cell metabolism reprogramming and cycle regulation was revealed
Update time:2018-01-04 18:19:48   【 Font: Large  Medium Small

 

           Tumor metabolic reprogramming and abnormal cell cycle regulation are two important characteristics of tumors. However, it is unclear how the two are coordinated to promote tumor cell proliferation and tumor development. This team found for the first time that in tumor cells, Plk1, an important cyclic regulatory protein, regulates the activity of G6PD, a key metabolic enzyme in the pentose phosphate pathway, and thus promotes the synthesis of biological macromolecules and the proliferation of tumor cells both in vitro and in vivo. Further mechanistic studies revealed that Plk1 modifies G6PD by binding and phosphorylation, resulting in an increase of G6PD-forming dimers, thereby promoting enzyme activity and the entire pentose phosphate pathway. Enhanced pentose phosphate pathway for tumor cell cycle progression and the occurrence and development of tumors have an important role in promoting. This study, for the first time, uncovered the new function of Plk1 in the regulation of biological macromolecule synthesis, revealed a new mechanism of coordination between metabolic reprogramming and cycle regulation and promotion of rapid proliferation of tumor cells, and potential therapeutic targets for clinical tumor Guiding significance.

          Wuhan EIAab Science Co., Ltd is advantage in technology, product, dedicated to provide quality and reliable for all users of products. There are some related products sold in our company related to this paper, such as Plk1(E1662h)、G6PD(E0716h) etc.

         doi:10.1038/s41467-017-01647-5

 

 

 

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