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The protein histidine phosphatase LHPP is a tumour suppressor
Update time:2018-06-03 19:11:39   【 Font: Large  Medium Small

   

    Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) belongs to the HAD-like hydrolase superfamily. LHPP is an exceptional enzyme which hydrolyzes not only oxygen-phosphorus bonds in inorganic pyrophosphate but also nitrogen-phosphorus bonds in phospholysine, phosphohistidine and imidodiphosphate in vitro. LHPP is expressed in the liver, kidney and moderately in the brain.

    On March 21, 2018, Nature published an article called The protein histidine phosphatase LHPP is a tumour suppressor. The article points out that LHPP is a protein histidine phosphatase and tumour suppressor, suggesting that deregulated histidine phosphorylation is oncogenic.

    Histidine phosphorylation, the so-called hidden phosphoproteome, is a poorly characterized post-translational modification of proteins. In this article, the authors demonstrate that LHPP is indeed a protein histidine phosphatase. Consistent with observations, global histidine phosphorylation was significantly upregulated in the liver tumours. Sustained, hepatic expression of LHPP in the hepatocellular carcinoma mouse model reduced tumour burden and prevented the loss of liver function. Finally, in patients with hepatocellular carcinoma, low expression of LHPP correlated with increased tumour severity and reduced overall survival. Thus, LHPP is a protein histidine phosphatase and tumour suppressor, suggesting that deregulated histidine phosphorylation is oncogenic.

    Wuhan EIAab Science Co., Ltd has developed LHPP protein, antibody and ELISA kit. Welcome scientific research workers to choose and purchase.

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