The main source of arterial injury includes vascular wall sclerosis, a phenomenon known as arteriosclerosis .The arteriosclerosis increases the risk of cardiovascular disease such as hypertension and atherosclerosis. However, the cause of arterial stiffness is still unknown.

On July 24, Immunity published Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen.

The article shows that when LYVE-1-expressing macrophages covering the outer wall of healthy arteries are absent, the arteries accumulate a large amount of collagen, which loses elasticity and becomes stiff. Macrophages may be protective umbrellas that protect the arteries from stiffness.

There is an interaction between macrophages and smooth muscle cells(SMCs).TheSMCs are responsible for the production of collagen, and interaction between the two cells can reduce collagen production. The LYVE-1 is essentially responsible for this protection. LYVE-1 binds to hyaluronic acid on the cell surface expressed by smooth muscle cells and is a necessary condition for MMP-9-mediated collagen degradation.

Arteriosclerosis is often associated with aging and precedes cardiovascular diseases such as atherosclerosis and aneurysms. This knowledge should help develop methods to improve the prevention and treatment of existing arterial diseases.

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