Recently, the Chinese research team found that phage lyase can kill bacteria that cause dental caries, but it is harmless to common oral symbiotic bacteria, and it can be confirmed by rat dental caries model to significantly reduce the degree of dental caries.

    Caries, commonly known as cavities or fangs, are oral diseases in which teeth are broken and gradually form cavities. They are the main cause of tooth loss. Oral diseases, including caries, have a great impact on our quality of life. According to the researchers, the production of dental caries is mainly caused by the long-term interaction of bacteria with food. The main caries are Streptococcus mutans and Streptococcus sobrinus.

    This study was based on the previous discovery that phage lyase has a broad spectrum of Streptococcus mutans, and further tested the killing effect on other oral fungi and common oral commensal bacteria. The results showed that phage lyase deformed common caries Streptococcus mutans and Streptococcus sobrinus and related biofilms have bactericidal effects, but have almost no killing effect on oral symbiotic bacteria such as Streptococcus sanguinis, Streptococcus oralis, and Streptococcus salivarius.

    The study found that phage lyase also kills Enterococcus faecalis that causes periapical periodontal infection and eliminates biofilm. Related research Activity of the Chimeric Lysin ClyR against Common Gram-Positive Oral Microbes and Its Anticaries Efficacy in Rat Models were recently published on Virus. This research means that phage lyase has a good prospect in the prevention and treatment of dental diseases such as dental caries, and it may provide new drugs and tooth care products for the prevention of oral diseases such as dental caries.