Essential hypertension is one of the most common chronic diseases in the world. With the improvement of living standards, life pressure, changes in nutritional structure and other factors, the prevalence rate increases year by year. Kidney is one of the target organs of essential hypertension, which can lead to renal failure and affect renal function.
Generally, obvious clinical symptoms have been developed to the end of renal damage, the treatment effect is very poor.
It is of great significance to discover the symptoms of kidney damage through medical means. Traditional renal function examination is generally to reflect the damage to the kidney parenchyma for the purpose, not a sensitive indicator. Therefore, the medical community continues to explore how to make effective and rapid diagnosis of early hypertensive nephropathy.
The discovery and clinical application of beta -2 microglobulin make the diagnosis of early renal damage easy.Beta-2 microglobulin is widely found in plasma, urine, saliva and colostrum. It is a small globulin produced by lymphocytes, platelets and polymorphonuclear white blood cells, and its molecular weight is 11.8kD. It is part of the beta (light) chain of human histocompatibility antigens (HLA) on the cell surface. The molecule contains a pair of disulfide bonds that contain no sugar and are similar in structure to the immunoglobulin stabilizer region.95% of beta 2-mg in the normal human body is filtered by glomeruli and 99.9% is reabsorbed in the proximal convoluted tubules and decomposed into amino acids, so the content of beta 2-mg in the blood and urine of normal people is extremely low. Beta 2-MG is relatively stable and can be used as an indicator of glomerular and tubular functional status.
E0260h is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the A Disintegrin and Metalloprotease 30 (Beta-2-microglobulin) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Beta-2-microglobulin. The ELISA analytical biochemical technique of the E0260h kit is based on Beta-2-microglobulin antibody-Beta-2-microglobulin antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Beta-2-microglobulin antigen targets in samples.
Product link:
https://www.eiaab.com.cn/product-detail/elisa_kit/b2mg_human/
