Language:
  
[Sign in] [Register]   

EIAab logo

EIAab news detail, please contact eiaab@eiaab.com if you have any questions about online orders and payment.
Index > >
PIP4 on dispersed trans-Golgi network mediates NLRP3 inflammasome activation
Update time:2019-10-22 19:16:22   【 Font: Large  Medium Small

Researchers at the University of Texas Southwestern Medical Center have discovered how DNA can trigger immune and autoimmune responses from within cells by discovering the DNA sensing enzyme cGAS.
The NLRP3 protein is the basis for inflammation of a group of autoinflammatory diseases called cryopyrin protein-associated periodic syndrome (CAPS), including familial cold urticaria (FCAS), gout and an Alzheimer's disease and disease-related brain cell inflammation. In order to cope with excessive harmful substances, including toxins and cholesterol crystals, the inflammatory body initiates the path of inflammatory cell death. Inflammatory bodies also increase the body's immune system substances, such as interleukins, which contribute to the body's immune response.
"A long-standing problem in this area is how NLRP3 is activated by many different drugs that do not appear to have any chemical or structural similarities," the researchers said.
They discovered a previously unknown structural change in NLRP3 in the cell through imaging and genetic methods. They found that different stimuli caused an organelle called the reverse Golgi network to split into giant vesicles or fluid vesicles. These vesicles contain a special lipid component (PI4P) that binds to specific regions of NLRP3, and their binding triggers a series of events that lead to inflammatory body activation.
"The uniqueness of the NLRP3 inflammatory corpuscle is that it can be stimulated by a large number of stimuli," the researchers said. "This study found that the NLRP3 inflammatory body does not directly recognize harmful substances, but rather detects the structural changes caused by a series of different compounds that cause cell damage. In fact, the activation of NLRP3 is reminiscent of the plant's 'guard model', a model that counters threats by detecting host targets that have been altered, so-called pathogen induction."
"The NLRP3 indirectly perceives various pathogens and dangerous molecules by disassembling the reverse Golgi tube network," the researchers added.
EIAAB SCIENCE INC, WUHAN has developed NLRP3 protein, antibody and ELISA kit.

by EIAab organize the information.
Hot Genes
Atf2 ASPRO ACE ALCAM C19orf80 Trap1a KSR2 Gdf5
Top Searches
Ubiquitin-protein ligase Ubiquitin ELISA metalloproteinase Asprosin Tumor necrosis TRAP1A Alpha
Why choose EIAAB
Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more
Further Information
About us Protein center Bank account Distributors Terms & Conditions Career eiaab.cn

Copyright & copy www.eiaab.com2006-2016 All Rights Reserved    EIAab         Email:eiaab@eiaab.com

Twitter