Language:
  
[Sign in] [Register]   

EIAab logo

EIAab news detail, please contact eiaab@eiaab.com if you have any questions about online orders and payment.
Index > >
Atomic structure of TRPM2 protein is revealed
Update time:2019-10-31 18:44:42   【 Font: Large  Medium Small

Scientists at the Van Andel Institute (VARI) have for the first time revealed the atomic structure of the protein TRPM2, which regulates core body temperature, mediates immune responses, and apoptosis, programmed cell death.
TRPM2 is part of the TRP superfamily, which mediates sensory stimuli such as pain, stress, vision, temperature, and taste. They are widely known as ion channel proteins, nested within the cell membrane, and act as chemistry into and out of cells. The gatekeeper of the signal. The eight proteins that make up the TRPM superfamily are part of this broader group.
TRPM2 protein may be a promising drug target for the treatment of oxidative stress-related neurological diseases (Alzheimer's and bipolar disorder, etc.) caused by chemical imbalances.
The atomic image of TRPM2 depicts a bell-like structure with a transmembrane domain on the shoulder of the clock and an extended NUDT9-H domain at the bell. In addition, the study also identified a new drug-binding site for ADPR, a signaling molecule involved in oxidative stress and metabolism, a finding that reversed the previously identified view that TRPM2 binds to ADPR in the NUDT9-H domain. The exact drug targets provide valuable details for designing treatments for body temperature-related diseases and preventing neuronal death during neurodegenerative diseases.
"Although we know that TRPM2 is a component of many important life processes and potential drug targets, we are not sure what it looks like or how it works," the researchers said. “Today's discovery has changed all of this and helped to understand this extremely important molecule more fully.”
EIAAB SCIENCE INC, WUHAN has developed TRPM2 protein, antibody and ELISA kit.
Welcome scientific research workers to choose and purchase.

TRPM2

by EIAab organize the information.
Hot Genes
Atf2 ASPRO ACE ALCAM C19orf80 Trap1a KSR2 Gdf5
Top Searches
Ubiquitin-protein ligase Ubiquitin ELISA metalloproteinase Tumor necrosis Asprosin TRAP1A Alpha
Why choose EIAAB
Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more
Further Information
About us Protein center Bank account Distributors Terms & Conditions Career eiaab.cn

Copyright & copy www.eiaab.com2006-2016 All Rights Reserved    EIAab         Email:eiaab@eiaab.com

Twitter