Posted by star
on 2018-08-01 20:13:58
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On the morning of July 31, 2018, EIAAB SCIENCE INC, WUHAN held a successful training about the application of ELISA kit.
Zhang Ting who is a member of the technology department mainly introduced the following three aspects to the company personnel: 1. Basic components of the ELISA Kit; 2. Application of ELISA Kit in biomedical science; 3. Application of ELISA in other fields. It mainly consists of three parts of ELISA test, as well as basic knowledge such as different classification according to the analysis principle. Examples are given to explain the applications of ELISA kit, which greatly strengthens the understanding of sales personnel and further clarifies the work content.
When Zhang Ting explained the related methods of the ELISA kit, everyone listened carefully and also actively participated in the communication. At the end of the presentation, the company personnel asked their own questions and Zhang Ting fluently answered all the questions. And we believe that the spirit and attitude of keeping improving in work with every personnel will certainly make the company go further!
Posted by star
on 2018-05-07 00:21:53
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Bacteriophages were found to kill bacteria in the wreckage of World War I soldiers. A century later, the virus is drawing new attention because of its potential role in the human body. From the ocean to the soil, bacteriophages are almost ubiquitous. Now, one study shows that humans absorb up to 30 billion phages each day through the gut. Although the exact location of the virus is still unknown, recent data and other studies have prompted scientists to suspect that a large number of phages in the body - the "phage group" - may influence the physiology by regulating the immune system. A study of various animals from corals to humans found that the phage abundance in the mucus layer was more than four times greater than that in the surrounding environment, as was the case for phagosomes that protect human gums and gut. As it turns out, the outer sheath of the bacteriophage binds to mucus that is secreted by the body in large quantities and mucus together with water. Attached to the mucus makes the phage to encounter more bacterial prey. As a result, it has been demonstrated in a series of in vitro studies that these viruses protect the basal cells from possible bacterial pathogens and thus provide an additional immunological layer.
Posted by star
on 2018-05-01 23:46:28
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Nuclear receptor coactivator-3 (NCOA3, SRC-3), a 1420-AA nuclear receptor coactivator, does not directly bind to DNA. It is recruited to specific gene promoters by interacting with nuclear hormone receptors such as the progesterone receptor, estrogen receptor, and peroxisome proliferation activated receptor and other transcription factors such as E2F1, PEA3, and AP1.
It is reported that NCOA3 which is amplified in breast cancer 1 (AIB1) and also plays an important role in lung, ovary, prostate and pancreatic cancer over-expresses in many cancer cells. [1] NCOA3 plays an important role in optimal activation of the PERK–eIF2α–ATF4 pathway. XBP1–NCOA3 axis regulates cell fate decisions in ER-positive breast cancer cells. The PERK–ATF4 arm directly upregulated vascular endothelial growth factor A (VEGFA) and Lysosomal-Associated Membrane Protein 3 (LAMP3), thereby regulating tumour vascularity and invasion.[2] Moreover, the phosphorylation of NCOA3 can further increase the transcriptional activity of NCOA3. So the phosphorylation of NCOA3 is also a biomarker for many cancers. [3]
On April 3, 2018, a heavy study which was done by the team of Bert O'Malley at Baylor College of Medicine was published in the top journal "Nature
Posted by star
on 2018-04-10 22:53:30
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On April 3, 2018, Nature published an online article called Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer. The article points out that the Warburg pathway enzyme PFKFB4 acts as a molecular fulcrum that couples sugar metabolism to transcriptional activation by stimulating SRC-3 to promote aggressive metastatic tumours.
PFKFB4 also known as 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 which in humans is encoded by the PFKFB4 gene is an activator of a key regulatory enzyme of glycolysis and phosphofructokinase. PFKFB4 is a bifunctional enzyme that can increase intracellular F2,6BP and, thus, flux through PFK-1 or decrease F2,6BP and PFK-1 activity resulting in increased shunting of glucose 6-phosphate for NADPH and ribose production. PFKFB4 was observed to be over-expressed in human tumors indicating a potential role in cancer development and/or progression. This protein is highly expressed in cancer cells and is induced by hypoxia and is essential to the survival of cancer cells under conditions of hypoxia. This suggests that PFKFB4 may be a useful molecular target for the development of anti-neoplastic agents.
EIAAB SCIENCE INC, WUHAN has developed PFKFB4 protein, PFKFB4 antibody, PFKFB4 ELISA KIT. Welcome scientific research workers to choose and purchase.
Posted by star
on 2018-03-14 18:50:41
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In 1962, Cohen first discovered the epidermal growth factor (EGF), which is a small molecule polypeptide widely found in human or animal body, consisting of 53 amino acids. EGF binds to the epidermal growth factor receptor (EGFR) on the cell membrane to regulate important biological processes together, such as cell differentiation, division and proliferation. Because of the in-depth study on the structure and mechanism of EGF, Montalcini and Cohen won the 1986 Nobel Prize in Physiology and Medicine.
A large number of studies have shown that EGF can delay the aging of the skin and restore the vitality of the epidermis, so that the skin can restore soft, elastic and normal tension, playing a role of anti-wrinkle. Besides, EGF can activate the basal cells of the skin, which can promote the healing of cutaneous and mucosal wounds, playing a role of anti-inflammatory, analgesic and preventing ulcers. In addition, EGF can also egulate the secretion of gastric acid and digestive, thereby protecting the gastrointestinal mucosa, and promoting mucosal injury repair.
According to the good physiological characteristics of EGF, it is often used as a medicine widely in the treatment of skin burns, corneal transplants and post-operative wounds, which shows good therapeutic effects. In recent years, EGF is often added to cosmetics as a bioactive agent for sun protection, whitening, anti-aging and other effects, which greatly improves the cosmetics skin care features and the quality and grade of cosmetics.
Due to the power of EGF, more and more researchers are interested in it. In order to meet the needs of researchers, EIAAB SCIENCE INC, WUHAN developed ......
