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Lipoxin A4 (LXA4) as a potential first trimester biochemical marker of intrauterine growth disorders
Update time:2018-03-21 01:52:33   【 Font: Large  Medium Small

Objective: To evaluate first trimester maternal serum levels of lipoxin A4 (LXA4) in prediction of intrauterine fetal growth.

Methods: Study group of 185 patients in singleton pregnancy was divided into three subgroups according to neonatal birthweight: ≤10th percentile (SGA), 11–89th percentile (AGA) and ≥90 percentile (LGA).

Results: We observed decreased values of LXA4 concentrations, both in SGA- and LGA groups, when compared to AGA (68.91 ± 33.72 and 68.30 ± 23.49 versus 102.13 ± 121.90, respectively).

Conclusions: Lipoxin A4 may become an biochemical marker in the prediction of intrauterine fetal growth disturbances; however, more studies need to be undertaken to investigate LXA4’s role in pregnancy.


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Source:The Journal of Maternal-Fetal & Neonatal Medicine      by Lipa M, Bomba-Opoń D, Lipa J, et al.
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