Bcl2 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comBcl2 ELISA Kit for Rat(Rattus norvegicus)

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Bcl2 (Gene name),

Apoptosis regulator Bcl-2 (Protein name ), BCL2_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (3)

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Gene name:

Bcl2(Bcl-2);

Protein name:

Apoptosis regulator Bcl-2;

Alternative:

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization with BAX requires intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity. Also interacts with APAF1, BBC3, BCL2L1, BNIPL, EI24, FKBP8, MRPL41, RAF-1, TP53BP2. Interacts with BAG1 in an ATP-dependent manner.

Function:

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

Subcellular Location:

Mitochondrion outer membrane Single-pass membrane protein Nucleus membrane Single-pass membrane protein Endoplasmic reticulum membrane Single-pass membrane protein

Protein Attributes:

Sequence length:

236

Sequence:

50:

100:

150:

200:

236:

PSMRPLFDFS | WLSLKTLLSL | ALVGACITLG | AYLGHK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.9996

String:

P49950

SMR:

P49950

Pfam:

PF00452

KEGG:

rno:24224

STRING:

10116.ENSRNOP00000003768

Uniprot:

P49950

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ELISA Kit for Rat Apoptosis regulator Bcl-2

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E0778r

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ELISA Kit for Rat Apoptosis regulator Bcl-2

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E0778b

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96T

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ELISA Kit for Rat Apoptosis regulator Bcl-2

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E0778h

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ELISA Kit for Rat Apoptosis regulator Bcl-2

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E0778m

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ELISA Kit for Rat Apoptosis regulator Bcl-2

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E0778c

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ELISA Kit for Rat Apoptosis regulator Bcl-2

Cat.:

E0778d

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96T

CLIA Kit for Rat Apoptosis regulator Bcl-2

Cat.:

U0778r

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96T

CLIA Kit for Rat Apoptosis regulator Bcl-2

Cat.:

U0778b

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MSDS:

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Packing:

96T

CLIA Kit for Rat Apoptosis regulator Bcl-2

Cat.:

U0778h

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MSDS:

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Packing:

96T

CLIA Kit for Rat Apoptosis regulator Bcl-2

Cat.:

U0778d

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Packing:

96T

CLIA Kit for Rat Apoptosis regulator Bcl-2

Cat.:

U0778m

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MSDS:

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Packing:

96T

CLIA Kit for Rat Apoptosis regulator Bcl-2

Cat.:

U0778c

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96T

Polyclonal Antibody for Rat Apoptosis regulator Bcl-2

Cat.:

P0778Rb-h

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40ug/0.2ml

Polyclonal Antibody for Rat Apoptosis regulator Bcl-2

Cat.:

P0778Rb-m

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40ug/0.2ml

Polyclonal Antibody for Rat Apoptosis regulator Bcl-2

Cat.:

P0778Rb-r

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40ug/0.2ml

Polyclonal Antibody for Rat Apoptosis regulator Bcl-2

Monoclonal Antibody for Rat Apoptosis regulator Bcl-2

Protein for Rat Apoptosis regulator Bcl-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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Citations

[1].

"Effect of cardamonin on hepatic ischemia reperfusion induced in rats: Role of nitric oxide"

Y Atef, H M.Ei-Fayoumi, M F.Mahmoud, et al.

From:European Journal of Pharmacology

[2].

"Role of Pigment Epithelium-Derived Factor (PEDF) in Arsenic-Induced Cell Apoptosis of Liver and Brain in a Rat Model"

Wei Zhang, Hongqi Feng, Yanhui Gao, Liyan Sun, Jing Wang, Yuanyuan Li, Cheng Wang, Lijun Zhao, Xinxin Hu, Huixin Sun, Yudan Wei, Dianjun Sun

From:Biological Trace Element Research

[3].

"Cromolyn chitosan nanoparticles as a novel protective approach for colorectal cancer"

Tare K. M, Shohda A. E, Aliaa Nabil E, et al.

From:Chemico-Biological Interactions

References

1.

"Cloning and sequencing of a cDNA encoding the rat Bcl-2 protein."
Sato T. , Irie S. , Krajewski S. , Reed J.C.
Gene140:291-292(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
2.

"Expression of members of the Bcl-2 gene family in the immature rat ovary: equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased Bax and constitutive Bcl-2 and Bcl-xlong messenger ribonucleic acid levels."
Tilly J.L. , Tilly K.I. , Kenton M.L. , Johnson A.L.
Endocrinology136:232-241(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Sprague-Dawley.
tissue: Ovary.
3.

"bcl-2 messenger RNA is localized in neurons of the developing and adult rat brain."
Castren E. , Ohga Y. , Berzaghi M.P. , Tzimagiorgis G. , Thoenen H. , Lindholm D.
Neuroscience61:165-177(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-172
4.

"Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect."
Eliseev R.A. , Malecki J. , Lester T. , Zhang Y. , Humphrey J. , Gunter T.E.
J. Biol. Chem.284:9692-9699(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPIF

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