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Bacteriophages may help maintain human health

Posted by star on 2018-02-04 18:01:15
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          Bacteriophages were found to kill bacteria in the wreckage of World War I soldiers. A century later, the virus is drawing new attention because of its potential role in the human body. From the ocean to the soil, bacteriophages are almost ubiquitous. Now, one study shows that humans absorb up to 30 billion phages each day through the gut. Although the exact location of the virus is still unknown, recent data and other studies have prompted scientists to suspect that a large number of phages in the body - the "phage group" - may influence the physiology by regulating the immune system. A study of various animals from corals to humans found that the phage abundance in the mucus layer was more than four times greater than that in the surrounding environment, as was the case for phagosomes that protect human gums and gut. As it turns out, the outer sheath of the bacteriophage binds to mucus that is secreted by the body in large quantities and mucus together with water. Attached to the mucus makes the phage to encounter more bacterial prey. As a result, it has been demonstrated in a series of in vitro studies that these viruses protect the basal cells from possible bacterial pathogens and thus provide an additional immunological layer.

 



New progress in hepatitis e vaccine development

Posted by star on 2018-01-31 00:08:48
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        The viral hepatitis caused by hepatitis virus is divided into a, b, c, d and e. Hepatitis e, also known as amyl hepatitis, is an acute viral hepatitis caused by RNA viruses, which is the main cause of severe liver problems.

         Hepatitis e is spread mainly through contaminated water and person-to-person contact, and is easily popular in areas with poor sanitation. According to the world health organization, about 20 million people are infected with the hepatitis e virus each year, of which more than 3 million people develop acute hepatitis e, and almost 57, 000 die. Among them, for pregnant women, the death rate of hepatitis e is higher. The average person is infected with the disease, with a death rate of about 1 to 3 percent, and a fifth for pregnant women.

        on December 9, 2011, Xiamen university professor NingShao  team developed hepatitis e vaccine for a class of new drug certificate issued by the state food and drug administration approval documents and production, is the first complete international hepatitis e vaccine clinical trials. The principle of the hepatitis a vaccine is the use of giant coli expression system to express hepatitis e virus capsid protein, then after purification of multiple capsid protein composition is a highly complex structure virus-like particles, has a large advantage of immune epitope, so after the immune body, can stimulate the body to produce a lot of blocking antibodies against hepatitis e virus invasion. The virus-like particles are produced by genetic engineering recombinant technology. The products contain no hepatitis e virus and have high safety.

        After a 4.5 year follow-up, the researchers found that they still had a......

A new antibody may block HIV infection

Posted by star on 2018-01-16 23:42:52
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        HIV(Human Immunodeficiency Virus), is an Lentivirus that infects the human immune system and is one of the antiretroviruses. In 1983, the human immunodeficiency virus was first detected in the United States. The virus destroys the body's immune system and causes the immune system to lose its resistance, leading to diseases and cancers that can survive in the body and eventually lead to AIDS.

        In a new study, the researchers from USA have produced a kind of three specific antibody, and the three specific antibody of three HIV combined fragments derived from the three kinds of natural antibodies,  that are effective in neutralizing many HIV strains.In the lab, this three specific antibody can prevent more HIV strains from infecting cells than a single natural antibody, and it can be incorporated into three different critical sites of HIV.

 

 

          At present, the researchers are planning an early clinical trial of the three-specific antibody among healthy people and people with HIV, and hope that it will eventually be used for long-term prevention and treatment of HIV. By combining with three different sites of HIV, the virus should be more difficult to escape from the three-specific antibody than a single natural antibody. Maybe this new antibody will stop the HIV infection. Wuhan EIAab research staff have developed various research kits and welcome the selection of scientific research personnel.

 

 



kill zombie cells can help stay young

Posted by star on 2018-01-14 22:59:49
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         There is a special kind of cell in mice that did not divide and wouldn't die but can make the animal accelerate ageing, the researchers found that clear away these 'senescent' cells can alleviate or even prevent certain illnesses and stimulate new tissue production.This year alone, it has been proved that clearing out the cells in mice can regain fitness, fur density and kidney function. It has also improved lung disease and even mended damaged cartilage. 

       We know that when a cell becomes mutation or damage it often stops dividing and may be secreting a distress signal to inform the immune system clearing out the abnormal cell,No one is quite sure when or why that happens. It has been suggested that the immune system stops responding to the cells.

 

       Lacking of universal features as marker to identify the senescent cells lead to the work very laborious . Senescent cells relay on protective mechanisms to stay undead state, different cell may have a unique way to protect itself from wiping out. reserchers identified six signalling pathways that prevent cell death, Then it was just a matter of finding compounds that would disrupt those pathways. 14 senolytics have been described in the literature, a peptide that activates a cell-death pathway and can restore lustrous hair and physical fitness to ageing mice , senolytic drugs just wipe out senescent cells which already exit ,they won't prevent the formation of such cells in the future, which means that senescence can continue to perform its original tumour-suppressing role in the body

      If eliminating senescent cells in humans does improv......

ELISA kit for Interleukin-2 and IL-2 receptors

Posted by star on 2018-01-08 21:56:14
Hits:67

          IL-2 (interleuin-2) is a kind of Interleukin, mainly produced by T cells or T cell lines. It is a type of cell growth factor in the immune system. It can regulate the activity of white blood cells in the immune system, promote the proliferation of Th0 and CTL. It participates in antibody response and the moderation of haematogenesis function. It also plays an important role in oncological surveillance. 

          IL-2 is part of the body's natural response to microbial infection, IL-2 mediates its effects by binding to IL-2 receptors, which is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes. IL-2R consist of three chains : α(also called IL-2Rα, CD25, or Tac antigen), β  (also called IL-2Rβ, or CD122), and γ (also called IL-2Rγ, γc, common gamma chain, or CD132).

 

           Welcome to choose and purchase the related products from Wuhan Eiaab Science Co.,Ltd , we have ELISA kit for Interleukin-2 and IL-2 receptors , which origin from different species, such as human, bovine, dog, pig, mouse, rat and rabbit.



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