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A new insight into the link between diabetes and cancer

Posted by star on 2018-08-13 19:38:09

    Epidemiological studies have suggested that diabetes is linked to an increase risk of cancer. And high glucose levels may be a prevailing factor that contributes to the link between diabetes and cancer, but little is known about the molecular basis of this link.

    With more than four years, fortunately, a team from Fudan University published the reaearch result in Nature on July, 19. The paper named “Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer” reveals that metformin which is an anti-diabetic drug mediates tumor suppression.

    As we all know, the conversion of 5mC to 5hmC occurs through an oxidative reaction catalyzed by the ten-eleven translocation (TET) and the level of 5hmC can be a mark for the progress of cancer. AMPK is a key nutrient or energy sensor that is highly sensitive to glucose availability.

    In this study, the team found the molecular mechanism: increased glucose levels impede AMPK-mediated phosphorylation at serine 99, which results in the destabilization of TET2 followed by dysregulation of both 5hmC and the tumor suppressive function of TET2 in vitro and in vivo.

    Wuhan EIAab Science Co., Ltd has developed the TET2 ELISA kit. Welcome scientific research workers to choose and purchase.

DNA replication is semiconservative

Posted by star on 2018-08-12 23:15:59

Watson and Crick recognized that their DNA model suggests a replication mechanism in which the two parental strands separate, allowing each separated strand to serve as a template for the synthesis of a complementary strand. According to this replication mechanism, which is termed the semiconservative model for DNA replication, each double-stranded daughter DNA molecule will have a conserved DNA strand that is derived from the parental DNA and a newly synthesized strand. At the time the semiconservative model was proposed, DNA denaturation was not understood and strand separation was, for a variety of reasons, considered to be impossible. Therefore, two alternative models, the conservative and dispersive models, also seemed possible.

The conservative model of replication makes two assumptions. First, the two strands of the double helix unwind at the replication site only to the extent needed for the base sequence there to be read by the polymerizing enzyme. Second, the two original strands remain entwined after replication so that one of the two DNA molecules present after replication contains both original strands (is conserved) and the other DNA molecule is made of two new strands.

The dispersive model of replication shares some of the features of the conservative model but predicts that each strand of the daughter DNA molecules has interspersed sections of both old and new DNA. Comparison of the three mechanisms reveals that conservative replication make different predictions about the composition of daughter DNA molecules after one or two rounds of replication. Therefore, it would be possible to establish the correct model, if some method could be devised to distinguish between new and old DNA strands.

In 1958, just five years after the ......

CMPK2 inhibitors - specific anti-inflammatory drugs

Posted by star on 2018-08-12 18:38:27

    On July 25th, an article published New mitochondrial DNA synthesis enables NLRP3 inflammasome activation in Nature pointed out that there is an important link between the signaling pathway that activates NLRP3 inflammasome and several severe chronic inflammatory diseases.

    Interleukin 1beta (IL-1beta) is an inflammatory cytokine, and the production of IL-1beta is usually very low. With the onset of injury, environmental stress, infection or chronic inflammation, the production of IL-1beta is usually significantly increased. The production and secretion of IL-1beta is regulated by inflammatory bodies. In addition to containing the Caspase-1 enzyme, the inflammasome contains other sensor proteins that respond to different signals caused by tissue damage or pathogen infection. For example, NLRP3 is one of the most important and versatile sensors and responsible for inflammatory body activation and tissue damage as well as IL-1beta production.The drug that closes the NLRP3 inflammasome has been an effective drug for the treatment of inflammatory diseases such as osteoarthritis, Alzheimer's disease and cancer.

    Cytosine monophosphate kinase 2 (CMPK2) plays an important role in NLRP3 activation and IL-1beta production before the onset of chronic inflammatory disease.

    CMPK2 inhibitors can improve inflammation, pain and tissue damage in patients with gout and osteoarthritis, for Alzheimer's and Parkinson's.

    Wuhan EIAab Science Co., Ltd has developed CMPK2 protein, antibody and ELISA kit. Welcome scientific research workers to choose and purchase.

The main source of arterial injury includes vascular wall sclerosis, a phenomenon known as arteriosclerosis .The arteriosclerosis increases the risk of cardiovascular disease such as hypertension and atherosclerosis. However, the cause of arterial stiffness is still unknown.

On July 24, Immunity published Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen.

The article shows that when LYVE-1-expressing macrophages covering the outer wall of healthy arteries are absent, the arteries accumulate a large amount of collagen, which loses elasticity and becomes stiff. Macrophages may be protective umbrellas that protect the arteries from stiffness.

There is an interaction between macrophages and smooth muscle cells(SMCs).TheSMCs are responsible for the production of collagen, and interaction between the two cells can reduce collagen production. The LYVE-1 is essentially responsible for this protection. LYVE-1 binds to hyaluronic acid on the cell surface expressed by smooth muscle cells and is a necessary condition for MMP-9-mediated collagen degradation.

Arteriosclerosis is often associated with aging and precedes cardiovascular diseases such as atherosclerosis and aneurysms. This knowledge should help develop methods to improve the prevention and treatment of existing arterial diseases.

Wuhan EIAab Science Co., Ltd has developed LYVE1 protein, antibody and ELISA kit. Welcome scientific research workers to choose and purchase.

The study found new genes for allergic rhinitis

Posted by star on 2018-08-08 19:39:46

    An international research team recently said that they have discovered 20 new risk genes related to allergic rhinitis, which is expected to find new targets for the prevention and treatment of allergic rhinitis.

    Allergic rhinitis is also known as hay fever. The patient is mainly allergic to pollen, dust mites and animal hair. It is characterized by paroxysmal sneezing, a large amount of nasal discharge, and itchy nose. In severe cases, symptoms such as itchy eyes, stuffy nose, and decreased sense of smell may occur.

    The international research team published Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis in the new issue of the journal Nature Genetics. They collected data of nearly 900,000 people and searched the risk genes associated with allergic rhinitis. It is the genetic difference between patients with allergic rhinitis and healthy people.

    The researchers first compared the genomes of 60,000 patients and 150,000 healthy people in the control group, identifying 42 risk genes associated with allergic rhinitis, some of which have been documented in the literature.

    Subsequently, the researchers compared the genomes of another 60,000 patients and 620,000 healthy people, confirming that 20 previously undiscovered risk genes are associated with allergic rhinitis. The researchers said that the identified risk genes could explain the cause of approximately 8% of allergic rhinitis cases.

    The researchers used the database to further confirm the function of these genes, and found that most of them are related to the immune system, and the risk genes of allergic......

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