Gene name:
CCL4 (LAG1;MIP1B;SCYA4) ;
Protein name:
C-C motif chemokine 4 ;
Alternative:
T-cell activation protein 2 (ACT-2) ;HC21 ;G-26 T-lymphocyte-secreted protein ;MIP-1-beta(1-69) ;Lymphocyte activation gene 1 protein (LAG-1) ;PAT 744 ;Macrophage inflammatory protein 1-beta (MIP-1-beta) ;SIS-gamma ;Protein H400 ;Small-inducible cytokine A4 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer and heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69).
Function:
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
Subcellular Location:
Secreted
Protein Attributes:
50:
MKLCVTVLSL | LMLVAAFCSP | ALSAPMGSDP | PTACCFSYTA | RKLPRNFVVD |
92:
YYETSSLCSQ | PAVVFQTKRS | KQVCADPSES | WVQEYVYDLE | LN
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Chicken
Human
Mouse
Rat
Pig
Dog
Bovine
Rabbit
ELISA Kit for Human C-C motif chemokine 4
ELISA Kit for Human C-C motif chemokine 4
ELISA Kit for Human C-C motif chemokine 4
ELISA Kit for Human C-C motif chemokine 4
ELISA Kit for Human C-C motif chemokine 4
ELISA Kit for Human C-C motif chemokine 4
ELISA Kit for Human C-C motif chemokine 4
ELISA Kit for Human C-C motif chemokine 4
CLIA Kit for Human C-C motif chemokine 4
CLIA Kit for Human C-C motif chemokine 4
CLIA Kit for Human C-C motif chemokine 4
CLIA Kit for Human C-C motif chemokine 4
CLIA Kit for Human C-C motif chemokine 4
CLIA Kit for Human C-C motif chemokine 4
CLIA Kit for Human C-C motif chemokine 4
CLIA Kit for Human C-C motif chemokine 4
Polyclonal Antibody for Human C-C motif chemokine 4
Polyclonal Antibody for Human C-C motif chemokine 4
Polyclonal Antibody for Human C-C motif chemokine 4
Polyclonal Antibody for Human C-C motif chemokine 4
Polyclonal Antibody for Human C-C motif chemokine 4
Polyclonal Antibody for Human C-C motif chemokine 4
Polyclonal Antibody for Human C-C motif chemokine 4
Polyclonal Antibody for Human C-C motif chemokine 4
Monoclonal Antibody for Human C-C motif chemokine 4
Monoclonal Antibody for Human C-C motif chemokine 4
Monoclonal Antibody for Human C-C motif chemokine 4
Monoclonal Antibody for Human C-C motif chemokine 4
Monoclonal Antibody for Human C-C motif chemokine 4
Monoclonal Antibody for Human C-C motif chemokine 4
Monoclonal Antibody for Human C-C motif chemokine 4
Monoclonal Antibody for Human C-C motif chemokine 4
Protein for Human C-C motif chemokine 4
Protein for Human C-C motif chemokine 4
Protein for Human C-C motif chemokine 4
Protein for Human C-C motif chemokine 4
Protein for Human C-C motif chemokine 4
Protein for Human C-C motif chemokine 4
Protein for Human C-C motif chemokine 4
Protein for Human C-C motif chemokine 4
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
T-cell .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
tissue :
Natural killer cell .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
T-cell .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
8.
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
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Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
9.
"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
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Nature440:1045-1049(2006)
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PubMed ]
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT THR-80
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 6-92;VARIANT THR-80
tissue :
T-cell .
12.
"Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : RECEPTOR INTERACTION
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION OF MIP-1-BETA(3-69) BY MASS SPECTROMETRY;FUNCTION;SUBUNIT
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR