Gene name:
CDK11A(CDC2L2;CDC2L3;PITSLREB);
Protein name:
Cyclin-dependent kinase 11A;
Alternative:
Cell division protein kinase 11A;Cell division cycle 2-like protein kinase 2;PITSLRE serine/threonine-protein kinase CDC2L2;Galactosyltransferase-associated protein kinase p58/GTA;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
The cleaved p110 isoform, p110C, binds to the serine/threonine kinase PAK1. The p58 isoform but not the p110 isoform or p110C interacts with CCND3. The p110 isoforms are found in large molecular weight complexes containing CCNL1 and SFRS7.
Function:
Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.
Subcellular Location:
Cytoplasm
Nucleus
Protein Attributes:
50:
MGDEKDSWKV | KTLDEILQEK | KRRKEQEEKA | EIKRLKNSDD | RDSKRDSLEE |
100:
GELRDHCMEI | TIRNSPYRRE | DSMEDRGEED | DSLAIKPPQQ | MSRKEKVHHR |
150:
KDEKRKEKWK | HARVKEREHE | RRKRHREEQD | KARREWERQK | RREMAREHSR |
200:
RERDRLEQLE | RKRERERKMR | EQQKEQREQK | ERERRAEERR | KEREARREVS |
250:
AHHRTMREDY | SDKVKASHWS | RSPPRPPRER | FELGDGRKPG | EARPAPAQKP |
300:
AQLKEEKMEE | RDLLSDLQDI | SDSERKTSSA | ESSSAESGSG | SEEEEEEEEE |
350:
EEEEGSTSEE | SEEEEEEEEE | EEEETGSNSE | EASEQSAEEV | SEEEMSEDEE |
400:
RENENHLLVV | PESRFDRDSG | ESEEAEEEVG | EGTPQSSALT | EGDYVPDSPA |
450:
LLPIELKQEL | PKYLPALQGC | RSVEEFQCLN | RIEEGTYGVV | YRAKDKKTDE |
500:
IVALKRLKME | KEKEGFPITS | LREINTILKA | QHPNIVTVRE | IVVGSNMDKI |
550:
YIVMNYVEHD | LKSLMETMKQ | PFLPGEVKTL | MIQLLRGVKH | LHDNWILHRD |
600:
LKTSNLLLSH | AGILKVGDFG | LAREYGSPLK | AYTPVVVTQW | YRAPELLLGA |
650:
KEYSTAVDMW | SVGCIFGELL | TQKPLFPGNS | EIDQINKVFK | ELGTPSEKIW |
700:
PGYSELPVVK | KMTFSEHPYN | NLRKRFGALL | SDQGFDLMNK | FLTYFPGRRI |
750:
SAEDGLKHEY | FRETPLPIDP | SMFPTWPAKS | EQQRVKRGTS | PRPPEGGLGY |
783:
SQLGDDDLKE | TGFHLTTTNQ | GASAAGPGFS | LKF
Vaild Sequence:
Related Databases
Uniprot: