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Index > Protein center > CDK16(Gene name) > Human
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  • CDK16 (Gene name),
  • Cyclin-dependent kinase 16 (Protein name ),  CDK16_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CDK16(PCTK1;PCTK1);
    Protein name:
    Cyclin-dependent kinase 16;
    Alternative:
    PCTAIRE-motif protein kinase 1;Cell division protein kinase 16;Serine/threonine-protein kinase PCTAIRE-1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Found in a complex containing CABLES1, CDK17 and TDRD7. Interacts with YWHAH, YWHAQ and YWHAZ.
    Function:
    May play a role in signal transduction cascades in terminally differentiated cells.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    496
    Sequence:
    50:
    MDRMKKIKRQ | LSMTLRGGRG | IDKTNGAPEQ | IGLDESGGGG | GSDPGEAPTR | 
    100:
    AAPGELRSAR | GPLSSAPEIV | HEDLKMGSDG | ESDQASATSS | DEVQSPVRVR | 
    150:
    MRNHPPRKIS | TEDINKRLSL | PADIRLPEGY | LEKLTLNSPI | FDKPLSRRLR | 
    200:
    RVSLSEIGFG | KLETYIKLDK | LGEGTYATVY | KGKSKLTDNL | VALKEIRLEH | 
    250:
    EEGAPCTAIR | EVSLLKDLKH | ANIVTLHDII | HTEKSLTLVF | EYLDKDLKQY | 
    300:
    LDDCGNIINM | HNVKLFLFQL | LRGLAYCHRQ | KVLHRDLKPQ | NLLINERGEL | 
    350:
    KLADFGLARA | KSIPTKTYSN | EVVTLWYRPP | DILLGSTDYS | TQIDMWGVGC | 
    400:
    IFYEMATGRP | LFPGSTVEEQ | LHFIFRILGT | PTEETWPGIL | SNEEFKTYNY | 
    450:
    PKYRAEALLS | HAPRLDSDGA | DLLTKLLQFE | GRNRISAEDA | MKHPFFLSLG | 
    496:
    ERIHKLPDTT | SIFALKEIQL | QKEASLRSSS | MPDSGRPAFR | VVDTEF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    SMR:
    KEGG:
    MIM:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cyclin-dependent kinase 16
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    E11154r
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    ELISA Kit for Human Cyclin-dependent kinase 16
    Cat.:
    E11154h
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    Packing:
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    ELISA Kit for Human Cyclin-dependent kinase 16
    Cat.:
    E11154m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Cyclin-dependent kinase 16
    Cat.:
    U11154h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Cyclin-dependent kinase 16
    Cat.:
    U11154m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Cyclin-dependent kinase 16
    Cat.:
    U11154r
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Cyclin-dependent kinase 16
    Cat.:
    P11154Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Cyclin-dependent kinase 16
    Cat.:
    P11154Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Cyclin-dependent kinase 16
    Cat.:
    P11154Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Cyclin-dependent kinase 16
    Monoclonal Antibody for Human Cyclin-dependent kinase 16
    Monoclonal Antibody for Human Cyclin-dependent kinase 16
    Protein for Human Cyclin-dependent kinase 16
    Protein for Human Cyclin-dependent kinase 16
    Protein for Human Cyclin-dependent kinase 16

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Fetal brain.
    2. 2.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Testis.
      tissue: Thalamus.
    4. 4.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Brain.
      tissue: Placenta.
    7. 7.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    8. 8.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78; SER-82; SER-95; SER-119 AND SER-138;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138; SER-153 AND SER-155;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42; SER-78; SER-82; SER-95; SER-119 AND SER-138;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-153;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 13.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-119 AND SER-153;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 14.
      "Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase."
      Shehata S.N. , Hunter R.W. , Ohta E. , Peggie M.W. , Lou H.J. , Sicheri F. , Zeqiraj E. , Turk B.E. , Sakamoto K.
      Cell. Signal.24:2085-2094(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;INTERACTION WITH CCNY
    15. 15.
      "Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic beta-cells."
      Chen X.Y. , Gu X.T. , Saiyin H. , Wan B. , Zhang Y.J. , Li J. , Wang Y.L. , Gao R. , Wang Y.F. , Dong W.P. , Najjar S.M. , Zhang C.Y. , Ding H.F. , Liu J.O. , Yu L.
      J. Biol. Chem.287:30368-30375(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;INTERACTION WITH BRSK2;SUBCELLULAR LOCATION;MUTAGENESIS OF SER-12; SER-153 AND LYS-194;PHOSPHORYLATION AT SER-12;TISSUE SPECIFICITY
    16. 16.
      "Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis."
      Mikolcevic P. , Sigl R. , Rauch V. , Hess M.W. , Pfaller K. , Barisic M. , Pelliniemi L.J. , Boesl M. , Geley S.
      Mol. Cell. Biol.32:868-879(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;INTERACTION WITH CCNY;MUTAGENESIS OF SER-119; SER-153 AND LYS-194
    17. 17.
      "Crystal structure of the PCTAIRE1 kinase in complex with indirubin e804."
      Structural genomics consortium (SGC)
      Submitted (2010-06) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 163-478
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