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Index > Protein center > Dkk1(Gene name) > Mouse
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  • Dkk1 (Gene name),
  • Dickkopf-related protein 1 (Protein name ),  DKK1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    Dkk1;
    Protein name:
    Dickkopf-related protein 1(Dickkopf-1;Dkk-1;mDkk-1);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts (via the C-termianl Cys-rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt-mediated signaling (By similarity). Interacts with LRP6.
    Function:
    Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    272
    Sequence:
    50:
    MMVVCAPAAV | RFLAVFTMMA | LCSLPLLGAS | ATLNSVLINS | NAIKNLPPPL | 
    100:
    GGAGGQPGSA | VSVAPGVLYE | GGNKYQTLDN | YQPYPCAEDE | ECGSDEYCSS | 
    150:
    PSRGAAGVGG | VQICLACRKR | RKRCMTHAMC | CPGNYCKNGI | CMPSDHSHFP | 
    200:
    RGEIEESIIE | NLGNDHNAAA | GDGYPRRTTL | TSKIYHTKGQ | EGSVCLRSSD | 
    250:
    CAAGLCCARH | FWSKICKPVL | KEGQVCTKHK | RKGSHGLEIF | QRCYCGEGLA | 
    272:
    CRIQKDHHQA | SNSSRLHTCQ | RH
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    KEGG:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Dickkopf-1
    Cat.:
    E0741h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Dickkopf-1
    Cat.:
    E0741m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Dickkopf-1
    Cat.:
    U0741h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Dickkopf-1
    Cat.:
    U0741m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Dickkopf-1
    Cat.:
    P0741Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Dickkopf-1
    Cat.:
    P0741Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Dickkopf-1
    Monoclonal Antibody for Mouse Dickkopf-1
    Protein for Mouse Dickkopf-1
    Protein for Mouse Dickkopf-1

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Citations
    [1].
    Delphine B. Maurela,Nathalie Boisseaub, Claude-Laurent Benhamou, Christelle Jaffré
    References
    1. 1.
      "Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction."
      Glinka A. , Wu W. , Delius H. , Monaghan A.P. , Blumenstock C. , Niehrs C.
      Nature391:357-362(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Molecular cloning and bioinformatic analysis of DKK1."
      Hu L. , Jiang G. , Yang J. , Liu S.
      Submitted (2011-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    5. 5.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Trophoblast stem cell.
    7. 7.
      "Function and biological roles of the Dickkopf family of Wnt modulators."
      Niehrs C.
      Oncogene25:7469-7481(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW OF THE DKK FAMILY
    8. 8.
      "Structural insight into the mechanisms of Wnt signaling antagonism by Dkk."
      Chen L. , Wang K. , Shao Y. , Huang J. , Li X. , Shan J. , Wu D. , Zheng J.J.
      J. Biol. Chem.283:23364-23370(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;INTERACTION WITH LRP5 AND LRP6;MUTAGENESIS OF HIS-210; LYS-217; ARG-242 AND HIS-267
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