Gene name:
EIF2AK2 (PKR;PRKR) ;
Protein name:
Interferon-induced, double-stranded RNA-activated protein kinase ;
Alternative:
Interferon-inducible RNA-dependent protein kinase ;Eukaryotic translation initiation factor 2-alpha kinase 2 (eIF-2A protein kinase 2) ;Protein kinase RNA-activated (PKR) ;P1/eIF-2A protein kinase ;p68 kinase ;2.7.10.2;Tyrosine-protein kinase EIF2AK2 ) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer. Interacts with STRBP (By similarity). Interacts with DNAJC3. Inhibited by direct interaction with viral proteins such as HCV E2, HCV NS5A and influenza A NS1. Activated by the interaction with HIV-1 Tat (By similarity). Forms a complex with FANCA, FANCC, FANCG and HSP70.
Function:
Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection. In adddition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity: phosphorylates CDK1 upon DNA damage. CDK1 phosphorylation triggers CDK1 polyubiquitination and subsequent proteolysis, thus leading to G2 arrest.
Subcellular Location:
N/A
Protein Attributes:
50:
MAGDLSAGFF | MEELNTYRQK | QGVVLKYQEL | PNSGPPHDRR | FTFQVIIDGR |
100:
EFPEGEGRSK | KEAKNAAAKL | AVEILNKEKK | AVSPLLLTTT | NSSEGLSMGN |
150:
YIGLINRIAQ | KKRLTVNYEQ | CASGVHGPEG | FHYKCKMGQK | EYSIGTGSTK |
200:
QEAKQLAAKL | AYLQILSEET | SVKSDYLSSG | SFATTCESQS | NSLVTSTLAS |
250:
ESSSEGDFSA | DTSEINSNSD | SLNSSSLLMN | GLRNNQRKAK | RSLAPRFDLP |
300:
DMKETKYTVD | KRFGMDFKEI | ELIGSGGFGQ | VFKAKHRIDG | KTYVIKRVKY |
350:
NNEKAEREVK | ALAKLDHVNI | VHYNGCWDGF | DYDPETSDDS | LESSDYDPEN |
400:
SKNSSRSKTK | CLFIQMEFCD | KGTLEQWIEK | RRGEKLDKVL | ALELFEQITK |
450:
GVDYIHSKKL | IHRDLKPSNI | FLVDTKQVKI | GDFGLVTSLK | NDGKRTRSKG |
500:
TLRYMSPEQI | SSQDYGKEVD | LYALGLILAE | LLHVCDTAFE | TSKFFTDLRD |
550:
GIISDIFDKK | EKTLLQKLLS | KKPEDRPNTS | EILRTLTVWK | KSPEKNERHT |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
ELISA Kit for Human Interferon-induced, double-stranded RNA-activated protein kinase
ELISA Kit for Human Interferon-induced, double-stranded RNA-activated protein kinase
ELISA Kit for Human Interferon-induced, double-stranded RNA-activated protein kinase
CLIA Kit for Human Interferon-induced, double-stranded RNA-activated protein kinase
CLIA Kit for Human Interferon-induced, double-stranded RNA-activated protein kinase
CLIA Kit for Human Interferon-induced, double-stranded RNA-activated protein kinase
Polyclonal Antibody for Human Interferon-induced, double-stranded RNA-activated protein kinase
Polyclonal Antibody for Human Interferon-induced, double-stranded RNA-activated protein kinase
Polyclonal Antibody for Human Interferon-induced, double-stranded RNA-activated protein kinase
Monoclonal Antibody for Human Interferon-induced, double-stranded RNA-activated protein kinase
Monoclonal Antibody for Human Interferon-induced, double-stranded RNA-activated protein kinase
Monoclonal Antibody for Human Interferon-induced, double-stranded RNA-activated protein kinase
Protein for Human Interferon-induced, double-stranded RNA-activated protein kinase
Protein for Human Interferon-induced, double-stranded RNA-activated protein kinase
Protein for Human Interferon-induced, double-stranded RNA-activated protein kinase
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 101-118 AND 309-325;INDUCTION
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Meurs E.
Submitted (1990-08) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Placenta .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Brain .
tissue :
Embryo .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
10.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Brain .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 2-18; 27-40; 70-77; 414-426 AND 430-440;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue :
Prostatic carcinoma .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DNAJC3
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HIV-1 TAT
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HCV NS5A
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH INFLUENZA A NS1 PROTEIN
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HCV E2 ENVELOPE PROTEIN
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH IKBKB
20.
"Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression."
Daher A.
,
Longuet M.
,
Dorin D.
,
Bois F.
,
Segeral E.
,
Bannwarth S.
,
Battisti P.-L.
,
Purcell D.F.
,
Benarous R.
,
Vaquero C.
,
Meurs E.F.
,
Gatignol A.
J. Biol. Chem.276:33899-33905(2001)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TARBP2
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-83; THR-88; THR-89; THR-90; SER-242; THR-255 AND THR-258;MUTAGENESIS OF SER-83; THR-88; THR-89; THR-90; SER-242; THR-255; THR-258 AND LYS-296;INHIBITION BY HCV E2 ENVELOPE PROTEIN
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : MUTAGENESIS;PHOSPHORYLATION AT THR-446 AND THR-451
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HHV-8 PROTEIN VIRF2
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH HHV-1 US11
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH NPM1;ENZYME REGULATION
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH MAP2K6
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN A COMPLEX WITH FANCA; FANCC; FANCG AND HSP70
28.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH TRAF2; TRAF5 AND TRAF6;SUBCELLULAR LOCATION
29.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INHIBITION BY VACCINIA VIRUS PROTEIN E3
30.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
31.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYR-101; TYR-162 AND TYR-293
32.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ADAR
33.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON ENZYME REGULATION
34.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH NCK1;ENZYME REGULATION
35.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DUS2L;ENZYME REGULATION
36.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83 AND SER-456;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
37.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
38.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH DHX9
39.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
40.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN HCV RESTRICTION
41.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
42.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION AS CDK1 KINASE UPON DNA DAMAGE;FUNCTION AS TYROSINE-PROTEIN KINASE
43.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
44.
"Double-stranded RNA-activated protein kinase inhibits hepatitis C virus replication but may be not essential in interferon treatment."
Chang J.H.
,
Kato N.
,
Muroyama R.
,
Taniguchi H.
,
Guleng B.
,
Dharel N.
,
Shao R.X.
,
Tateishi K.
,
Jazag A.
,
Kawabe T.
,
Omata M.
Liver Int.30:311-318(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN HCV RESTRICTION
45.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;PHOSPHORYLATION AT THR-451
46.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
47.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
48.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;TISSUE SPECIFICITY;PHOSPHORYLATION
49.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
50.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
51.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;IDENTIFICATION BY MASS SPECTROMETRY;PHOSPHORYLATION
52.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN HBV RESTRICTION
53.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
54.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
55.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
56.
"Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity."
Shen S.
,
Niso-Santano M.
,
Adjemian S.
,
Takehara T.
,
Malik S.A.
,
Minoux H.
,
Souquere S.
,
Marino G.
,
Lachkar S.
,
Senovilla L.
,
Galluzzi L.
,
Kepp O.
,
Pierron G.
,
Maiuri M.C.
,
Hikita H.
,
Kroemer R.
,
Kroemer G.
Mol. Cell48:667-680(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH STAT3
57.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
58.
"Novel role of PKR in inflammasome activation and HMGB1 release."
Lu B.
,
Nakamura T.
,
Inouye K.
,
Li J.
,
Tang Y.
,
Lundbaeck P.
,
Valdes-Ferrer S.I.
,
Olofsson P.S.
,
Kalb T.
,
Roth J.
,
Zou Y.
,
Erlandsson-Harris H.
,
Yang H.
,
Ting J.P.
,
Wang H.
,
Andersson U.
,
Antoine D.J.
,
Chavan S.S.
,
Hotamisligil G.S.
,
Tracey K.J.
more...
Nature488:670-674(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH NLRP1; NLRP3; NLRC4 AND AIM2;AUTOPHOSPHORYLATION
59.
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P.
,
Lasa M.
,
Polevoda B.
,
Gazquez C.
,
Elosegui-Artola A.
,
Kim D.S.
,
De Juan-Pardo E.
,
Demeyer K.
,
Hole K.
,
Larrea E.
,
Timmerman E.
,
Prieto J.
,
Arnesen T.
,
Sherman F.
,
Gevaert K.
,
Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
60.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
61.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
62.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
63.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
64.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
65.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;ISGYLATION AT LYS-69 AND LYS-159;ENZYME REGULATION
66.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TOS NSS;ENZYME REGULATION
67.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN MV RESTRICTION
68.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
69.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN HCV RESTRICTION
70.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 1-175
71.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 258-550 IN COMPLEX WITH EIF2ALPHA;PHOSPHORYLATION AT THR-446
72.
"Patterns of somatic mutation in human cancer genomes."
Greenman C.
,
Stephens P.
,
Smith R.
,
Dalgliesh G.L.
,
Hunter C.
,
Bignell G.
,
Davies H.
,
Teague J.
,
Butler A.
,
Stevens C.
,
Edkins S.
,
O'Meara S.
,
Vastrik I.
,
Schmidt E.E.
,
Avis T.
,
Barthorpe S.
,
Bhamra G.
,
Buck G.
,
Choudhury B.
,
Clements J.
,
Cole J.
,
Dicks E.
,
Forbes S.
,
Gray K.
,
Halliday K.
,
Harrison R.
,
Hills K.
,
Hinton J.
,
Jenkinson A.
,
Jones D.
,
Menzies A.
,
Mironenko T.
,
Perry J.
,
Raine K.
,
Richardson D.
,
Shepherd R.
,
Small A.
,
Tofts C.
,
Varian J.
,
Webb T.
,
West S.
,
Widaa S.
,
Yates A.
,
Cahill D.P.
,
Louis D.N.
,
Goldstraw P.
,
Nicholson A.G.
,
Brasseur F.
,
Looijenga L.
,
Weber B.L.
,
Chiew Y.-E.
,
DeFazio A.
,
Greaves M.F.
,
Green A.R.
,
Campbell P.
,
Birney E.
,
Easton D.F.
,
Chenevix-Trench G.
,
Tan M.-H.
,
Khoo S.K.
,
Teh B.T.
,
Yuen S.T.
,
Leung S.Y.
,
Wooster R.
,
Futreal P.A.
,
Stratton M.R.
more...
Nature446:153-158(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS [LARGE SCALE ANALYSIS] GLU-428; VAL-439 AND VAL-506