Gene name:
Eif2ak2 (Prkr) ;
Protein name:
Interferon-induced, double-stranded RNA-activated protein kinase ;
Alternative:
Interferon-inducible RNA-dependent protein kinase ;Eukaryotic translation initiation factor 2-alpha kinase 2 (eIF-2A protein kinase 2) ;2.7.10.2;Tyrosine-protein kinase EIF2AK2 ) ;Protein kinase RNA-activated (PKR) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Homodimer (By similarity). Interacts with DNAJC3 (By similarity). Interacts with STRBP. Forms a complex with FANCA, FANCC, FANCG and HSP70.
Function:
Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection. In adddition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity: phosphorylates CDK1 upon DNA damage. CDK1 phosphorylation triggers CDK1 polyubiquitination and subsequent proteolysis, thus leading to G2 arrest.
Subcellular Location:
N/A
Protein Attributes:
50:
MASDTPGFYV | DKLNKYSQIH | KVKIIYKEIS | VTGPPHDRRF | TFQVIIEERE |
100:
FPEGEGRSKQ | EAKNNAAKLA | VEILDNENKV | DSHTDASEQG | LIEGNYIGLV |
150:
NSFAQKENLP | VNFELCDPDS | QLPHRFICKC | KIGQTTYGTG | FGANKKEAKQ |
200:
LAAKNAYQKL | SEKSPSKTGF | VTSLSSDFSS | SSSITSNSAS | QSASGRDFED |
250:
IFMNGLREKR | KSGVKVPSDD | VLRNKYTLDD | RFSKDFEDIE | EIGSGGFGQV |
300:
FKAKHRIDGK | TYAIKRITYN | TKKAKREVQA | LAELNHANIV | QYRVCWEGED |
350:
YDYDPENSTN | GDTSRYKTRC | LFIQMEFCDK | GTLQQWLEKR | NRSQEDKALV |
400:
LELFEQIVTG | VDYIHSKGLI | HRDLKPGNIF | LVDEKHIKIG | DFGLATALEN |
450:
DGNPRTKYTG | TPQYMSPEQK | SSLVEYGKEV | DIFALGLILA | ELLHICKTDS |
500:
EKIEFFQLLR | NGIFSDDIFD | NKEKSLLQKL | LSSKPRERPN | TSEILKTLAE |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
ELISA Kit for Rat Interferon-induced, double-stranded RNA-activated protein kinase
ELISA Kit for Rat Interferon-induced, double-stranded RNA-activated protein kinase
ELISA Kit for Rat Interferon-induced, double-stranded RNA-activated protein kinase
CLIA Kit for Rat Interferon-induced, double-stranded RNA-activated protein kinase
CLIA Kit for Rat Interferon-induced, double-stranded RNA-activated protein kinase
CLIA Kit for Rat Interferon-induced, double-stranded RNA-activated protein kinase
Polyclonal Antibody for Rat Interferon-induced, double-stranded RNA-activated protein kinase
Polyclonal Antibody for Rat Interferon-induced, double-stranded RNA-activated protein kinase
Polyclonal Antibody for Rat Interferon-induced, double-stranded RNA-activated protein kinase
Monoclonal Antibody for Rat Interferon-induced, double-stranded RNA-activated protein kinase
Monoclonal Antibody for Rat Interferon-induced, double-stranded RNA-activated protein kinase
Monoclonal Antibody for Rat Interferon-induced, double-stranded RNA-activated protein kinase
Protein for Rat Interferon-induced, double-stranded RNA-activated protein kinase
Protein for Rat Interferon-induced, double-stranded RNA-activated protein kinase
Protein for Rat Interferon-induced, double-stranded RNA-activated protein kinase
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Sprague-Dawley .
tissue :
Brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH STRBP
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION