Protein name:
Eukaryotic elongation factor 2 kinase (eEF-2 kinase;eEF-2K) ;
Alternative:
Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Monomer or homodimer.
Function:
Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.
Subcellular Location:
N/A
Protein Attributes:
50:
MADEDLIFRL | EGVDGGGSSG | AGRHGDSDTD | SDDDEGYFIC | PITDDHMSNQ |
100:
NVNSKGQGYY | NNLLKTECGS | TGSPASSFHF | KEAWKHAIEK | AKHMPDPWAE |
150:
FHLEDIATEH | ATRHRYNAVT | GEWLKDEVLI | KMASQPFGRG | AMRECFRTKK |
200:
LSNFLHAQHW | KGASNYVAKR | YLEPVDRSVY | FEDVQLQMEA | KLWGEEYNRH |
250:
KPPKQVDIMQ | MCIIELKDRQ | GQPLFHLEHY | IEGKYIKYNS | NSGFVRDDNI |
300:
RLTPQAFSHF | TFERSGHQLI | VVDIQGVGDL | YTDPQIHTEK | GTDFGDGNLG |
350:
VRGMALFFYS | HACNRICQSM | GLAPFDLSPR | EQDAVNQSTK | LLQSAKTILR |
400:
GTEEKCGSPR | IRTLSGSRPP | LLLRLSENSG | DENMSDVTFD | SLPSSPSSAT |
450:
PHSQKLDHLH | WPVFGDLDNM | GPRDHDRMDN | HRDSENSGDS | GYPSEKRSDL |
500:
DDPEPREHGH | SNGNRRPESD | EDSLGSSGRV | CVETWNLLNP | SRLHLPRPSA |
550:
VALEVQRLNA | LDLGRKIGKS | VLGKVHLAMV | RYHEGGRFCE | KDEEWDQESA |
600:
IFHLEHAADL | GELEAIVGLG | LMYSQLPHHI | LADVSLEETE | ENKTKGFDYL |
650:
LKAAEAGDRQ | SMILVARAFD | TGLNLSPDRC | QDWSEALHWY | NTALETTDCD |
700:
EGGEYDGIQD | EPQYALLARE | AEMLLTGGFG | LDKNPQRSGD | LYTQAAEAAM |
724:
EAMKGRLANQ | YYEKAEEAWA | QMEE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
ELISA Kit for Rat eEF-2 kinase
ELISA Kit for Rat eEF-2 kinase
ELISA Kit for Rat eEF-2 kinase
CLIA Kit for Rat eEF-2 kinase
CLIA Kit for Rat eEF-2 kinase
CLIA Kit for Rat eEF-2 kinase
Polyclonal Antibody for Rat eEF-2 kinase
Polyclonal Antibody for Rat eEF-2 kinase
Polyclonal Antibody for Rat eEF-2 kinase
Monoclonal Antibody for Rat eEF-2 kinase
Monoclonal Antibody for Rat eEF-2 kinase
Monoclonal Antibody for Rat eEF-2 kinase
Protein for Rat eEF-2 kinase
Protein for Rat eEF-2 kinase
Protein for Rat eEF-2 kinase
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Skeletal muscle .
2.
"Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase."
Ryazanov A.G.
,
Ward M.D.
,
Mendola C.E.
,
Pavur K.S.
,
Dorovkov M.V.
,
Wiedmann M.
,
Erdjument-Bromage H.
,
Tempst P.
,
Parmer T.G.
,
Prostko C.R.
,
Germino F.J.
,
Hait W.N.
Proc. Natl. Acad. Sci. U.S.A.94:4884-4889(1997)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
New England Deaconess Hospital .
tissue :
Pheochromocytoma .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : AUTOPHOSPHORYLATION
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-499 BY PKA