Protein name:
Heparanase ;
Alternative:
Endo-glucoronidase ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Heterodimer; heterodimer formation between the 8 kDa and the 50 kDa subunits is required for enzyme activity. Interacts with TF; the interaction, inhibited by heparin, enhances the generation of activated factor X and activates coagulation. Interacts with HRG; the interaction is enhanced at acidic pH, partially inhibits binding of HPSE to cell surface receptors and modulates its enzymatic activity. Interacts with SDC1; the interaction enhances the shedding of SDC1.
Function:
Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Highly selective enzyme cleaving HSPGs at specific intrachain sites. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extacellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis.
Subcellular Location:
Lysosome membrane
Peripheral membrane protein
Secreted
Nucleus
Proheparanase is secreted via vesicles of the Golgi. Interacts with cell membrane heparan sulfate proteoglycans (HSPGs). Endocytosed and accumulates in endosomes. Transferred to lysosomes where it is proteolytically cleaved to produce the active enzyme. Under certain stimuli, transferred to the cell surface. Colocalizes with SDC1 in endosomal/lysosomal vesicles. Accumulates in perinuclear lysosomal vesicles. Heparin retains proheparanase in the extracellular medium (By similarity). Associates with lipid rafts.
Protein Attributes:
50:
MLRLLLLWLW | GPLGALAQGA | PAGTAPTDDV | VDLEFYTKRP | LRSVSPSFLS |
100:
ITIDASLATD | PRFLTFLGSP | RLRALARGLS | PAYLRFGGTK | TDFLIFDPDK |
150:
EPTSEERSYW | KSQVNHDICR | SEPVSAAVLR | KLQVEWPFQE | LLLLREQYQK |
200:
EFKNSTYSRS | SVDMLYSFAK | CSGLDLIFGL | NALLRTPDLR | WNSSNAQLLL |
250:
DYCSSKGYNI | SWELGNEPNS | FWKKAHILID | GLQLGEDFVE | LHKLLQRSAF |
300:
QNAKLYGPDI | GQPRGKTVKL | LRSFLKAGGE | VIDSLTWHHY | YLNGRIATKE |
350:
DFLSSDVLDT | FILSVQKILK | VTKEITPGKK | VWLGETSSAY | GGGAPLLSNT |
400:
FAAGFMWLDK | LGLSAQMGIE | VVMRQVFFGA | GNYHLVDENF | EPLPDYWLSL |
450:
LFKKLVGPRV | LLSRVKGPDR | SKLRVYLHCT | NVYHPRYQEG | DLTLYVLNLH |
500:
NVTKHLKVPP | PLFRKPVDTY | LLKPSGPDGL | LSKSVQLNGQ | ILKMVDEQTL |
535:
PALTEKPLPA | GSALSLPAFS | YGFFVIRNAK | IAACI
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
Bovine
Chicken
ELISA Kit for Mouse Heparanase
ELISA Kit for Mouse Heparanase
ELISA Kit for Mouse Heparanase
ELISA Kit for Mouse Heparanase
ELISA Kit for Mouse Heparanase
CLIA Kit for Mouse Heparanase
CLIA Kit for Mouse Heparanase
CLIA Kit for Mouse Heparanase
CLIA Kit for Mouse Heparanase
CLIA Kit for Mouse Heparanase
Polyclonal Antibody for Mouse Heparanase
Polyclonal Antibody for Mouse Heparanase
Polyclonal Antibody for Mouse Heparanase
Polyclonal Antibody for Mouse Heparanase
Polyclonal Antibody for Mouse Heparanase
Monoclonal Antibody for Mouse Heparanase
Monoclonal Antibody for Mouse Heparanase
Monoclonal Antibody for Mouse Heparanase
Monoclonal Antibody for Mouse Heparanase
Monoclonal Antibody for Mouse Heparanase
Protein for Mouse Heparanase
Protein for Mouse Heparanase
Protein for Mouse Heparanase
Protein for Mouse Heparanase
Protein for Mouse Heparanase
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
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SJL/J .
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PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 28-57 AND 150-179;GLYCOSYLATION;BIOPHYSICOCHEMICAL PROPERTIES;ENZYME REGULATION;SUBUNIT
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
strain :
NOD .
tissue :
Thymus .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Lung .
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