Mapk8ip1 ELISA Kit for Mouse(Mus musculus) | EIAab.comMapk8ip1 ELISA Kit for Mouse(Mus musculus)

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Mapk8ip1 (Gene name),

C-Jun-amino-terminal kinase-interacting protein 1 (Protein name ), JIP1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Mapk8ip1(Ib1;Jip1;Mapk8ip;Prkm8ip);

Protein name:

C-Jun-amino-terminal kinase-interacting protein 1(JIP-1;JNK-interacting protein 1);

Alternative:

JNK MAP kinase scaffold protein 1;Islet-brain-1(IB-1);Mitogen-activated protein kinase 8-interacting protein 1;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Forms homo- or heterooligomeric complexes. Binds specific components of the JNK signaling pathway namely MAPK8, MAPK9, MAPK10, MAP2K7, MAP3K10, MAP3K11 and DLK1. Also binds the proline-rich domain-containing splice variant of apolipoprotein E receptor 2 (ApoER2) (By similarity). Binds the cytoplasmic tails of LRP1 and LRP2 (Megalin). Binds the TPR motif-containing C-terminal of kinesin light chain, KLC1. Pre-assembled MAPK8IP1 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location. Interacts with the cytoplasmic domain of APP (By similarity). Interacts, via the PID domain, with RGNEF. Interacts with MAP3K7 and VRK2.

Function:

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interations with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response.

Subcellular Location:

Cytoplasm Cytoplasm perinuclear region Nucleus Endoplasmic reticulum membrane Mitochondrion membrane Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus.

Protein Attributes:

Sequence length:

707

Sequence:

50:

100:

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300:

350:

400:

450:

500:

550:

600:

650:

700:

707:

TEDIYLE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:19099

String:

Q9WVI9

SMR:

Q9WVI9

STRING:

10090.ENSMUSP00000050773

Pfam:

PF00640

UniGene:

Mm.2720

Uniprot:

Q9WVI9

FOR

ELISA Kit for Mouse JIP-1

CLIA Kit for Mouse JIP-1

Polyclonal Antibody for Mouse JIP-1

Monoclonal Antibody for Mouse JIP-1

Protein for Mouse JIP-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"A cytoplasmic inhibitor of the JNK signal transduction pathway."
Dickens M. , Rogers J.S. , Cavanagh J. , Raitano A. , Xia Z. , Halpern J.R. , Greenberg M.E. , Sawyers C.L. , Davis R.J.
Science277:693-696(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM JIP-1A);POSSIBLE FUNCTION
tissue: Brain.
2.

"Molecular cloning of multiple splicing variants of JIP-1 preferentially expressed in brain."
Kim I.-J. , Lee K.-W. , Park B.Y. , Lee J.-K. , Park J. , Choi I.Y. , Eom S.-J. , Chang T.-S. , Kim M.J. , Yeom Y.I. , Chang S.K. , Lee Y.-D. , Choi E.-J. , Han P.-L.
J. Neurochem.72:1335-1343(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS JIP-1B; JIP-1C; JIP-1D AND JIP-1E)
strain: BALB/c.
tissue: Brain.
3.

"The JIP group of mitogen-activated protein kinase scaffold proteins."
Yasuda J. , Whitmarsh A.J. , Cavanagh J. , Sharma M. , Davis R.J.
Mol. Cell. Biol.19:7245-7254(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM JIP-1B);CHARACTERIZATION
tissue: Brain.
4.

"High-throughput sequence identification of gene coding variants within alcohol-related QTLs."
Ehringer M.A. , Thompson J. , Conroy O. , Xu Y. , Yang F. , Canniff J. , Beeson M. , Gordon L. , Bennett B. , Johnson T.E. , Sikela J.M.
Mamm. Genome12:657-663(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM JIP-1B);VARIANT ARG-10
strain: ILS.
strain: ISS.
5.

"Interaction of Alzheimer's beta-amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade."
Taru H. , Iijima K. , Hase M. , Kirino Y. , Yagi Y. , Suzuki T.
J. Biol. Chem.277:20070-20078(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM JIP-1B)
tissue: Brain.
6.

"Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons."
Meyer D. , Liu A. , Margolis B.
J. Biol. Chem.274:35113-35118(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARHGEF28;SUBCELLULAR LOCATION
7.

"Spatial, temporal and subcellular localization of islet-brain 1 (IB1), a homologue of JIP-1, in mouse brain."
Pellet J.-B. , Haefliger J.-A. , Staple J.K. , Widmann C. , Welker E. , Hirling H. , Bonny C. , Nicod P. , Catsicas S. , Waeber G. , Riederer B.M.
Eur. J. Neurosci.12:621-632(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;SUBCELLULAR LOCATION
8.

"Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction."
Gotthardt M. , Trommsdorff M. , Nevitt M.F. , Shelton J. , Richardson J.A. , Stockinger W. , Nimpf J. , Herz J.
J. Biol. Chem.275:25616-25624(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LRPS
9.

"Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules."
Verhey K.J. , Meyer D. , Deehan R. , Blenis J. , Schnapp B.J. , Rapoport T.A. , Margolis B.
J. Cell Biol.152:959-970(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KLC1
tissue: Brain.
10.

"Requirement of the JIP1 scaffold protein for stress-induced JNK activation."
Whitmarsh A.J. , Kuan C.-Y. , Kennedy N.J. , Kelkar N. , Haydar T.F. , Mordes J.P. , Appel M. , Rossini A.A. , Jones S.N. , Flavell R.A. , Rakic P. , Davis R.J.
Genes Dev.15:2421-2432(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"Common and divergent roles for members of the mouse DCX superfamily."
Coquelle F.M. , Levy T. , Bergmann S. , Wolf S.G. , Bar-El D. , Sapir T. , Brody Y. , Orr I. , Barkai N. , Eichele G. , Reiner O.
Cell Cycle5:976-983(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DCLK2

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