Protein name:
Junctophilin-4 (JP-4) ;
Alternative:
Junctophilin-like 1 protein ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory.
Subcellular Location:
Cell membrane
Peripheral membrane protein
Endoplasmic reticulum membrane
Single-pass type IV membrane protein
Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane.
Protein Attributes:
50:
MSPGGKFDFD | DGGCYVGGWE | AGRAHGYGVC | TGPGAQGEYS | GCWAHGFESL |
100:
GVFTGPGGHS | YQGHWQQGKR | EGLGVERKSR | WTYRGEWLGG | LKGRSGVWES |
150:
VSGLRYAGLW | KDGFQDGYGT | ETYSDGGTYQ | GQWQAGKRHG | YGVRQSVPYH |
200:
QAALLRSPRR | TSLDSGHSDP | PTPPPPLPLP | GDEGGSPASG | SRGGFVLAGP |
250:
GDADGASSRK | RTPAAGGFFR | RSLLLSGLRA | GGRRSSLGSK | RGSLRSEVSS |
300:
EVGSTGPPGS | EASGPPIPAP | PALIEGSATE | VYAGEWRADR | RSGYGVSQRS |
350:
NGLRYEGEWL | GNRRHGYGRT | TRPDGSREEG | KYKRNRLVHG | GRVRSLLPLA |
400:
LRRGKVKEKV | DRAVEGARRA | VSAARQRQEI | AAARAADALL | KAVAASSVAE |
450:
KAVEAARMAK | LIAQDLQPML | EAPGRRPRQD | SGGSDTEPLD | EDSPGVYENG |
500:
LTPSEGSPEL | PSSPASSHQP | WRAPACRSPL | PPGGNWGPFS | SPKAWPEEWG |
550:
GPGEQAEELA | GYEAEDEAGV | QGPGPRDGSP | LLGGCSDSSG | SLREEEGEDE |
600:
ESLPQLRAPG | GSESEPVTTP | VLRGLSSRGP | DAGCLTEEVE | EPAPTERPAQ |
628:
PGAANPLVVG | AVALLDLSLA | FLFSQLLT
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Human
Polyclonal Antibody for Mouse JP-4
Polyclonal Antibody for Mouse JP-4
Polyclonal Antibody for Mouse JP-4
Monoclonal Antibody for Mouse JP-4
Monoclonal Antibody for Mouse JP-4
Monoclonal Antibody for Mouse JP-4
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;POSSIBLE FUNCTION
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C57BL/6J .
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain :
C57BL/6 .
tissue :
Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain :
C57BL/6J .
tissue :
Forelimb .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
C57BL/6 .
tissue :
Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE