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Index > Protein center > Jph4(Gene name) > Mouse
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  • Jph4 (Gene name),
  • Junctophilin-4 (Protein name ),  JPH4_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Jph4(Jphl1);
    Protein name:
    Junctophilin-4(JP-4);
    Alternative:
    Junctophilin-like 1 protein;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory.
    Subcellular Location:
    Cell membrane Peripheral membrane protein Endoplasmic reticulum membrane Single-pass type IV membrane protein Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane.
    Protein Attributes:
    Sequence length:
    628
    Sequence:
    50:
    MSPGGKFDFD | DGGCYVGGWE | AGRAHGYGVC | TGPGAQGEYS | GCWAHGFESL | 
    100:
    GVFTGPGGHS | YQGHWQQGKR | EGLGVERKSR | WTYRGEWLGG | LKGRSGVWES | 
    150:
    VSGLRYAGLW | KDGFQDGYGT | ETYSDGGTYQ | GQWQAGKRHG | YGVRQSVPYH | 
    200:
    QAALLRSPRR | TSLDSGHSDP | PTPPPPLPLP | GDEGGSPASG | SRGGFVLAGP | 
    250:
    GDADGASSRK | RTPAAGGFFR | RSLLLSGLRA | GGRRSSLGSK | RGSLRSEVSS | 
    300:
    EVGSTGPPGS | EASGPPIPAP | PALIEGSATE | VYAGEWRADR | RSGYGVSQRS | 
    350:
    NGLRYEGEWL | GNRRHGYGRT | TRPDGSREEG | KYKRNRLVHG | GRVRSLLPLA | 
    400:
    LRRGKVKEKV | DRAVEGARRA | VSAARQRQEI | AAARAADALL | KAVAASSVAE | 
    450:
    KAVEAARMAK | LIAQDLQPML | EAPGRRPRQD | SGGSDTEPLD | EDSPGVYENG | 
    500:
    LTPSEGSPEL | PSSPASSHQP | WRAPACRSPL | PPGGNWGPFS | SPKAWPEEWG | 
    550:
    GPGEQAEELA | GYEAEDEAGV | QGPGPRDGSP | LLGGCSDSSG | SLREEEGEDE | 
    600:
    ESLPQLRAPG | GSESEPVTTP | VLRGLSSRGP | DAGCLTEEVE | EPAPTERPAQ | 
    628:
    PGAANPLVVG | AVALLDLSLA | FLFSQLLT
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse JP-4
    ELISA Kit for Mouse JP-4
    ELISA Kit for Mouse JP-4
    CLIA Kit for Mouse JP-4
    CLIA Kit for Mouse JP-4
    CLIA Kit for Mouse JP-4
    Polyclonal Antibody for Mouse JP-4
    Polyclonal Antibody for Mouse JP-4
    Polyclonal Antibody for Mouse JP-4
    Monoclonal Antibody for Mouse JP-4
    Monoclonal Antibody for Mouse JP-4
    Monoclonal Antibody for Mouse JP-4
    Protein for Mouse JP-4
    Protein for Mouse JP-4
    Protein for Mouse JP-4

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Coexpression of junctophilin type 3 and type 4 in brain."
      Nishi M. , Sakagami H. , Komazaki S. , Kondo H. , Takeshima H.
      Brain Res. Mol. Brain Res.118:102-110(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;POSSIBLE FUNCTION
      strain: C57BL/6J.
      tissue: Brain.
    2. 2.
      "Molecular cloning and functional characterization of a novel subclass of junctophilins in the brain."
      Savaskan N.E. , Brauer A.U.
      Submitted (2003-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      strain: C57BL/6.
      tissue: Brain.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      strain: C57BL/6J.
      tissue: Forelimb.
    4. 4.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6.
      tissue: Brain.
    6. 6.
      "Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins."
      Moriguchi S. , Nishi M. , Komazaki S. , Sakagami H. , Miyazaki T. , Masumiya H. , Saito S.Y. , Watanabe M. , Kondo H. , Yawo H. , Fukunaga K. , Takeshima H.
      Proc. Natl. Acad. Sci. U.S.A.103:10811-10816(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
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