Gene name:
CCDC109B (MCUB) ;
Protein name:
Mitochondrial calcium uniporter regulatory subunit MCUb (MCUb) ;
Alternative:
Essential MCU regulator (EMRE) ;Coiled-coil domain-containing protein 109B ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterotetramer with MCU; this reduces MCU channel activity. Homooligomer (By similarity). Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1.
Function:
Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
Subcellular Location:
Mitochondrion inner membrane
Multi-pass membrane protein
Protein Attributes:
50:
MLQRGLWPWR | TRLLPTPGTW | RPARPWPLPP | PPQVLRVKLC | GNVKYYQSHH |
100:
YSTVVPPDEI | TVIYRHGLPL | VTLTLPSRKE | RCQFVVKPML | STVGSFLQDL |
150:
QNEDKGIKTA | AIFTADGNMI | SASTLMDILL | MNDFKLVINK | IAYDVQCPKR |
200:
EKPSNEHTAE | MEHMKSLVHR | LFTILHLEES | QKKREHHLLE | KIDHLKEQLQ |
250:
PLEQVKAGIE | AHSEAKTSGL | LWAGLALLSI | QGGALAWLTW | WVYSWDIMEP |
300:
VTYFITFANS | MVFFAYFIVT | RQDYTYSAVK | SRQFLQFFHK | KSKQQHFDVQ |
336:
QYNKLKEDLA | KAKESLKQAR | HSLCLQMQVE | ELNEKN
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Human
Mouse
Mouse
Polyclonal Antibody for Human MCUb
Polyclonal Antibody for Human MCUb
Polyclonal Antibody for Human MCUb
Polyclonal Antibody for Human MCUb
Monoclonal Antibody for Human MCUb
Monoclonal Antibody for Human MCUb
Monoclonal Antibody for Human MCUb
Monoclonal Antibody for Human MCUb
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;IDENTIFICATION IN THE UNIPLEX COMPLEX