MDK ELISA Kit for Human(Homo sapiens) | EIAab.comMDK ELISA Kit for Human(Homo sapiens)

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Index > Protein center > MDK(Gene name) > Human

MDK (Gene name),

Midkine (Protein name ), MK_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

MDK(MK1;NEGF2);

Protein name:

Midkine(MK);

Alternative:

Midgestation and kidney protein;Amphiregulin-associated protein(ARAP);Neurite outgrowth-promoting protein;Neurite outgrowth-promoting factor 2;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Interacts with ALK.

Function:

Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

143

Sequence:

50:

100:

143:

KVRQGTLKKA | RYNAQCQETI | RVTKPCTPKT | KAKAKAKKGK | GKD

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P21741

KEGG:

hsa:4192

Pfam:

PF01091

STRING:

9606.ENSP00000352852

UniGene:

Hs.82045

MIM:

162096

String:

P21741

Uniprot:

P21741

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ELISA Kit for Human MK

Cat.:

E0631m

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Packing:

96T

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ELISA Kit for Human MK

Cat.:

E0631h

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Packing:

96T

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ELISA Kit for Human MK

Cat.:

E0631r

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96T

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CLIA Kit for Human MK

Cat.:

U0631r

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MSDS:

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Packing:

96T

CLIA Kit for Human MK

Cat.:

U0631h

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Manual:

Looking for manual.

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Packing:

96T

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CLIA Kit for Human MK

Cat.:

U0631m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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Polyclonal Antibody for Human MK

Cat.:

P0631Rb-r

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human MK

Cat.:

P0631Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human MK

Cat.:

P0631Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human MK

Protein for Human MK

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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Citations

[1].

"COMPARATIVE STUDY BETWEEN DKK-1 AND AFP FOR DIAGNOSING OF HEPATOCELLULAR CARCINOMA AMONG EGYPTIAN PATIENTS"

Mohamed F Z, Barakat L A A, Radwan N H, et al.

From:"EUROPEAN JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH"

References

1.

"A new family of heparin-binding factors: strong conservation of midkine (MK) sequences between the human and the mouse."
Tsutsui J. , Uehara K. , Kadomatsu K. , Matsubara S. , Muramatsu T.
Biochem. Biophys. Res. Commun.176:792-797(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Kidney.
2.

"Cloning, characterization and developmental regulation of two members of a novel human gene family of neurite outgrowth-promoting proteins."
Kretschmer P.J. , Fairhurst J.L. , Decker M.M. , Chan C.P. , Gluzman Y. , Boehlen P. , Kovesdi I.
Growth Factors5:99-114(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;INDUCTION
tissue: Fetal brain.
3.

"Genomic structure of human midkine (MK), a retinoic acid-responsive growth/differentiation factor."
Uehara K. , Matsubara S. , Kadomatsu K. , Tsutsui J. , Muramatsu T.
J. Biochem.111:563-567(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Structure of the gene coding for the human retinoic acid-inducible factor, MK."
Fairhurst J.L. , Kretschmer P.J. , Gluzman Y. , Boehlen P. , Kovesdi I.
DNA Cell Biol.12:139-147(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue: Fetal brain.
5.

"Abnormal expression, highly efficient detection and novel truncations of midkine in human tumors, cancers and cell lines."
Tao P. , Xu D. , Lin S. , Ouyang G.L. , Chang Y. , Chen Q. , Yuan Y. , Zhuo X. , Luo Q. , Li J. , Li B. , Ruan L. , Li Q. , Li Z.
Cancer Lett.253:60-67(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY
6.

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D. , Noguchi H. , Totoki Y. , Toyoda A. , Kuroki Y. , Dewar K. , Lloyd C. , Itoh T. , Takeda T. , Kim D.-W. , She X. , Barlow K.F. , Bloom T. , Bruford E. , Chang J.L. , Cuomo C.A. , Eichler E. , FitzGerald M.G. , more...
Nature440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Uterus.
8.

"Amphiregulin-associated protein: complete amino acid sequence of a protein produced by the 12-0-tetradecanoylphorbol-13-acetate-treated human breast adenocarcinoma cell line MCF-7."
Shoyab M. , McDonald V.L. , Dick K. , Modrell B. , Malik N. , Plowman G.D.
Biochem. Biophys. Res. Commun.179:572-578(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-143
9.

"Identification of novel heparin-releasable proteins, as well as the cytokines midkine and pleiotrophin, in human postheparin plasma."
Novotny W.F. , Maffi T. , Mehta R.L. , Milner P.G.
Arterioscler. Thromb.13:1798-1805(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-35;INDUCTION
tissue: Plasma.
10.

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z. , Henzel W.J.
Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-35
11.

"Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types."
Stoica G.E. , Kuo A. , Powers C. , Bowden E.T. , Sale E.B. , Riegel A.T. , Wellstein A.
J. Biol. Chem.277:35990-35998(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ALK;FUNCTION
12.

"Solution structure of midkine, a new heparin-binding growth factor."
Iwasaki W. , Nagata K. , Hatanaka H. , Inui T. , Kimura T. , Muramatsu T. , Yoshida K. , Tasumi M. , Inagaki F.
EMBO J.16:6936-6946(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 23-81 AND 84-126;HOMODIMERIZATION

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