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Index > Protein center > MAP2K1(Gene name) > Rabbit
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  • MAP2K1 (Gene name),
  • Dual specificity mitogen-activated protein kinase kinase 1 (Protein name ),  MP2K1_RABIT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    MAP2K1(MEK1;PRKMK1);
    Protein name:
    Dual specificity mitogen-activated protein kinase kinase 1(MAP kinase kinase 1;MAPKK 1);
    Alternative:
    MAPK/ERK kinase 1(MEK 1);ERK activator kinase 1;
    Organism:
    Rabbit (Oryctolagus cuniculus). 
    General Annotation
    Sub Unit:
    Interacts with MORG1. Interacts with ARRB2. Found in a complex with at least BRAF, HRAS1, MAP2K1, MAPK3 and RGS14 (By similarity). Interacts with VRK2.
    Function:
    Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    393
    Sequence:
    50:
    MPKKKPTPIQ | LNPAPDGSAV | NGTSSAETNL | EALQKKLEEL | ELDEQQRKRL | 
    100:
    EAFLTQKQKV | GELKDDDFEK | ISELGAGNGG | VVFKVSHKPS | GLVMARKLIH | 
    150:
    LEIKPAIRNQ | IIRELQVLHE | CNSPYIVGFY | GAFYSDGEIS | ICMEHMDGGS | 
    200:
    LDQVLKKAGR | IPEQILGKVS | IAVIKGLTYL | REKHKIMHRD | VKPSNILVNS | 
    250:
    RGEIKLCDFG | VSGQLIDSMA | NSFVGTRSYM | SPERLQGTHY | SVQSDIWSMG | 
    300:
    LSLVEMAVGR | YPIPPPDAKE | LELMFGCQVE | GDAAETPPRP | RTPGRPLSSY | 
    350:
    GMDSRPPMAI | FELLDYIVNE | PPPKLPSAVF | SLEFQDFVNK | CLIKNPAERA | 
    393:
    DLKQLMVHAF | IKRSDAEEVD | FAGWLCSTIG | LNQPSTPTHA | AGV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Rabbit MAP kinase kinase 1
    Cat.:
    E10995h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Rabbit MAP kinase kinase 1
    Cat.:
    E10995m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Rabbit MAP kinase kinase 1
    Cat.:
    E10995r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rabbit MAP kinase kinase 1
    MSDS:
    Please sign in first.
    CLIA Kit for Rabbit MAP kinase kinase 1
    Cat.:
    U10995m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rabbit MAP kinase kinase 1
    Cat.:
    U10995h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rabbit MAP kinase kinase 1
    MSDS:
    Please sign in first.
    CLIA Kit for Rabbit MAP kinase kinase 1
    Cat.:
    U10995r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rabbit MAP kinase kinase 1
    Cat.:
    P10995Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rabbit MAP kinase kinase 1
    Polyclonal Antibody for Rabbit MAP kinase kinase 1
    Polyclonal Antibody for Rabbit MAP kinase kinase 1
    Monoclonal Antibody for Rabbit MAP kinase kinase 1
    Monoclonal Antibody for Rabbit MAP kinase kinase 1
    Monoclonal Antibody for Rabbit MAP kinase kinase 1
    Monoclonal Antibody for Rabbit MAP kinase kinase 1
    Protein for Rabbit MAP kinase kinase 1
    Protein for Rabbit MAP kinase kinase 1
    Protein for Rabbit MAP kinase kinase 1
    Protein for Rabbit MAP kinase kinase 1

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    References
    1. 1.
      "Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1."
      Alessi D.R. , Saito Y. , Campbell D.G. , Cohen P. , Sithanadam G. , Rapp U. , Ashworth A. , Marshall C.J. , Cowley S.
      EMBO J.13:1610-1619(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PHOSPHORYLATION AT SER-218 AND SER-222 BY RAF
    2. 2.
      "The amino acid sequence of a mammalian MAP kinase kinase."
      Ashworth A. , Nakielny S. , Cohen P. , Marshall C.
      Oncogene7:2555-2556(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-393;PARTIAL PROTEIN SEQUENCE
      tissue: Brain.
      tissue: Skeletal muscle.
    3. 3.
      "MAP kinase kinase from rabbit skeletal muscle. A novel dual specificity enzyme showing homology to yeast protein kinases involved in pheromone-dependent signal transduction."
      Nakielny S. , Campbell D.G. , Cohen P.
      FEBS Lett.308:183-189(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-16; 85-96 AND 190-201
      tissue: Skeletal muscle.
    4. 4.
      "Renaturation and partial peptide sequencing of mitogen-activated protein kinase (MAP kinase) activator from rabbit skeletal muscle."
      Wu J. , Michel H. , Rossomando A. , Haystead T. , Shabanowitz J. , Hunt D.F. , Sturgill T.W.
      Biochem. J.285:701-705(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 85-96 AND 190-201
      tissue: Skeletal muscle.
    5. 5.
      "A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK."
      Brennan D.F. , Dar A.C. , Hertz N.T. , Chao W.C. , Burlingame A.L. , Shokat K.M. , Barford D.
      Nature472:366-369(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.46 ANGSTROMS) IN COMPLEX WITH ATP AND HUMAN KSR2;PHOSPHORYLATION
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