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Index > Protein center > Map2k5(Gene name) > Mouse
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  • Map2k5 (Gene name),
  • Dual specificity mitogen-activated protein kinase kinase 5 (Protein name ),  MP2K5_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Map2k5(Mek5;Mkk5;Prkmk5);
    Protein name:
    Dual specificity mitogen-activated protein kinase kinase 5(MAP kinase kinase 5;MAPKK 5);
    Alternative:
    MAPK/ERK kinase 5(MEK 5);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with PARD6A, MAP3K3 and MAPK7. Forms a complex with SQSTM1 and PRKCZ or PRKCI.
    Function:
    Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appear to play a critical role in protecting cells from stress-induced apopotosis, neuronal survival and cardiac development and angiogenesis.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    448
    Sequence:
    50:
    MLWLALGPFC | AMENQVLVIR | IKIPNSGAVD | WTVHSGPQLL | FRDVLDVIGQ | 
    100:
    VLPEATTTAF | EYEDEDGDRI | TVRSDEEMKA | MLSYYYSTVM | EQQVNGQLIE | 
    150:
    PLQIFPRACK | PPGERNIHGL | KVNTRAGPSQ | HTSPVVSDSL | PSNSLKKSSA | 
    200:
    ELRKILANGQ | MNEQDIRYRD | TLGHGNGGTV | YKAHHVPSGK | ILAVKVILLD | 
    250:
    ITLELQKQIM | SELEILYKCD | SSYIIGFYGA | FFVENRISIC | TEFMDGGSLD | 
    300:
    VYRKIPEHVL | GRIAVAVVKG | LTYLWSLKIL | HRDVKPSNML | VNTGGQVKLC | 
    350:
    DFGVSTQLVN | SIAKTYVGTN | AYMAPERISG | EQYGIHSDVW | SLGISFMELA | 
    400:
    LGRFPYPQIQ | KNQGSLMPLQ | LLQCIVDEDS | PVLPLGEFSE | PFVHFITQCM | 
    448:
    RKQPKERPAP | EELMGHPFIV | QFNDGNSTVV | SMWVCRALEE | RRSQQGPP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    KEGG:
    Pfam:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse MAP kinase kinase 5
    Cat.:
    E10343h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse MAP kinase kinase 5
    Cat.:
    E10343m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse MAP kinase kinase 5
    Cat.:
    E10343r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse MAP kinase kinase 5
    Cat.:
    U10343h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse MAP kinase kinase 5
    Cat.:
    U10343r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse MAP kinase kinase 5
    Cat.:
    U10343m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse MAP kinase kinase 5
    Polyclonal Antibody for Mouse MAP kinase kinase 5
    Polyclonal Antibody for Mouse MAP kinase kinase 5
    Cat.:
    P10343Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse MAP kinase kinase 5
    Monoclonal Antibody for Mouse MAP kinase kinase 5
    Monoclonal Antibody for Mouse MAP kinase kinase 5
    Protein for Mouse MAP kinase kinase 5
    Protein for Mouse MAP kinase kinase 5
    Protein for Mouse MAP kinase kinase 5

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus."
      Kamakura S. , Moriguchi T. , Nishida E.
      J. Biol. Chem.274:26563-26571(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;MUTAGENESIS OF SER-311 AND THR-315
      tissue: Brain.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
      strain: C57BL/6J.
      tissue: Head.
      tissue: Hypothalamus.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
      strain: Czech II.
      tissue: Mammary gland.
    4. 4.
      "Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins."
      Lamark T. , Perander M. , Outzen H. , Kristiansen K. , Oevervatn A. , Michaelsen E. , Bjoerkoey G. , Johansen T.
      J. Biol. Chem.278:34568-34581(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SQSTM1; PRKCZ; PRKCI; PARD6A AND MAP3K3;DOMAIN
    5. 5.
      "PB1 domain-dependent signaling complex is required for extracellular signal-regulated kinase 5 activation."
      Nakamura K. , Uhlik M.T. , Johnson N.L. , Hahn K.M. , Johnson G.L.
      Mol. Cell. Biol.26:2065-2079(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DOMAIN;INTERACTION WITH MAP3K2 AND MAPK7;MUTAGENESIS OF ARG-20; ILE-21; ASP-64; GLU-65; GLY-67 AND ASP-68
    6. 6.
      "Solution structure of the PB1 domain of mouse mitogen activated protein kinase kinase 5 (MAP2K5)."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2006-01) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 7-107
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