Protein name:
Crossover junction endonuclease MUS81 ;
Alternative:
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
May self-associate. Interacts with EME1, EME2 and CHEK2. Interacts with BLM, and this interaction may stimulate the endonuclease activity of MUS81. Interacts with SLX4/BTBD12; this interaction is direct and links the MUS81-EME1 complex to SLX4, which may coordinate the action of the structure-specific endonuclease during DNA repair. Interacts with DCLRE1B/Apollo.
Function:
Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.
Subcellular Location:
Nucleus
nucleolus
Recruited to foci of DNA damage in S-phase cells.
Protein Attributes:
50:
MAEPVRLGRK | RPLPVCPNPL | FVRWLTEWRD | EAASRGRHTR | FVFQKALRSL |
100:
QRYPLPLRNG | KEAKILQHFG | DRLCRMLDER | LKEHLASGGD | HAPSSPSGKK |
150:
RASKGPPAQV | QGSSMPVPTQ | PQAGSTNAGY | WPAQNSGARE | ILLQLYREHL |
200:
NSDGHSFLTK | EELLQKCAQK | TPRVVPESSR | PWPALRGLLH | RNLVLRTHRP |
250:
ARYALTPEGL | ELAQKLAEAE | GLSTLNTAFQ | PEEHHEESPV | PEAILSEPGT |
300:
TEVGVQQRPL | ELRPSEYRVL | LCVDIGETRG | AGHRPEMLRE | LQRLRVPHTV |
350:
RKLHVGDFVW | VAQETRPRDP | ERPGELVLDH | IVERKRLDDL | CSSIIDGRFR |
400:
EQKFRLKRCG | LGHRIYLVEE | HGSVQNLSLP | ESTLLQAVTN | TQVIDGFFVK |
450:
RTMDIKESAG | YLALLTKGLE | RLYQGHTLHS | RPWGTPGDAE | SEAKPSTNPL |
500:
CSLLTFSDFN | AEAVKNKAQS | VREVFARQLM | QVRGLSGEKA | AALVDRYSTP |
550:
ASLLAAYDAC | ATTKEQEMLL | STVKCGRLQR | NLGPALSRTL | YQLYCSHSPL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
ELISA Kit for Rat Crossover junction endonuclease MUS81
ELISA Kit for Rat Crossover junction endonuclease MUS81
ELISA Kit for Rat Crossover junction endonuclease MUS81
CLIA Kit for Rat Crossover junction endonuclease MUS81
CLIA Kit for Rat Crossover junction endonuclease MUS81
CLIA Kit for Rat Crossover junction endonuclease MUS81
Polyclonal Antibody for Rat Crossover junction endonuclease MUS81
Polyclonal Antibody for Rat Crossover junction endonuclease MUS81
Polyclonal Antibody for Rat Crossover junction endonuclease MUS81
Monoclonal Antibody for Rat Crossover junction endonuclease MUS81
Monoclonal Antibody for Rat Crossover junction endonuclease MUS81
Monoclonal Antibody for Rat Crossover junction endonuclease MUS81
Protein for Rat Crossover junction endonuclease MUS81
Protein for Rat Crossover junction endonuclease MUS81
Protein for Rat Crossover junction endonuclease MUS81
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Thymus .