Mylk ELISA Kit for Mouse(Mus musculus) | EIAab.comMylk ELISA Kit for Mouse(Mus musculus)

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Mylk (Gene name),

Myosin light chain kinase, smooth muscle (Protein name ), MYLK_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Mylk;

Protein name:

Myosin light chain kinase, smooth muscle(MLCK);

Alternative:

Telokin;Kinase-related protein(KRP);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with SVIL.

Function:

Calcium/calmodulin-dependent enzyme implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activty (By similarity). Implicated in the regulation of endothelial as well as vascular permeability. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis.

Subcellular Location:

Cytoplasm Tagged isoform 1 colocalizes with stress fibers. Tagged Smooth muscle isoform is found throughout the cytoplasm with higher levels near the plasma membrane.

Protein Attributes:

Sequence length:

1941

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1941:

KYTCKAVNSL | GEATCTAELI | VETMEEGEGE | EGGEEEEEEE | E

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.33360

String:

Q6PDN3

Pfam:

PF00041

SMR:

Q6PDN3

Uniprot:

Q6PDN3

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ELISA Kit for Mouse MLCK

Cat.:

E1106h

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96T

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ELISA Kit for Mouse MLCK

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ELISA Kit for Mouse MLCK

Cat.:

E1106b

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96T

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ELISA Kit for Mouse MLCK

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ELISA Kit for Mouse MLCK

Cat.:

E1106c

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Packing:

96T

ELISA Kit for Mouse MLCK

Cat.:

E1106m

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Packing:

96T

CLIA Kit for Mouse MLCK

Cat.:

U1106m

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Packing:

96T

CLIA Kit for Mouse MLCK

Cat.:

U1106c

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MSDS:

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Packing:

96T

CLIA Kit for Mouse MLCK

Cat.:

U1106b

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MSDS:

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Packing:

96T

CLIA Kit for Mouse MLCK

MSDS:

Please sign in first.

CLIA Kit for Mouse MLCK

MSDS:

Please sign in first.

CLIA Kit for Mouse MLCK

Cat.:

U1106h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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Polyclonal Antibody for Mouse MLCK

Cat.:

P1106Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse MLCK

Cat.:

P1106Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse MLCK

Monoclonal Antibody for Mouse MLCK

Protein for Mouse MLCK

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Smooth muscle myosin light chain kinase expression in cardiac and skeletal muscle."
Herring B.P. , Dixon S.A. , Gallagher P.J.
Am. J. Physiol.279:C1656-C1664(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
strain: C3H.
tissue: Cardiac myocyte.
2.

"Telokin expression is restricted to smooth muscle tissues during mouse development."
Herring B.P. , Lyons G.E. , Hoggatt A.M. , Gallagher P.J.
Am. J. Physiol.280:C12-C21(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
strain: Swiss Webster / NIH.
3.

"220- and 130-kDa MLCKs have distinct tissue distributions and intracellular localization patterns."
Blue E.K. , Goeckeler Z.M. , Jin Y. , Hou L. , Dixon S.A. , Herring B.P. , Wysolmerski R.B. , Gallagher P.J.
Am. J. Physiol.282:C451-C460(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
strain: C3H.
tissue: Cardiac myocyte.
4.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain: C57BL/6J.
tissue: Wolffian duct.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain: C3H/He.
strain: FVB/N.
tissue: Colon.
tissue: Mammary gland.
tissue: Osteoblast.
6.

"The myosin light chain kinase gene is not duplicated in mouse: partial structure and chromosomal localization of Mylk."
Giorgi D.G. , Ferraz C. , Mattei M.-G. , Demaille J. , Rouquier S.
Genomics75:49-56(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-1561 (ISOFORM 1)
strain: C57BL/6J.
7.

"Intestinal infection with Giardia spp. reduces epithelial barrier function in a myosin light chain kinase-dependent fashion."
Scott K.G.-E. , Meddings J.B. , Kirk D.R. , Lees-Miller S.P. , Buret A.G.
Gastroenterology123:1179-1190(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN GIARDIASIS
8.

"Deletion of MLCK210 induces subtle changes in vascular reactivity but does not affect cardiac function."
Ohlmann P. , Tesse A. , Loichot C. , Ralay Ranaivo H. , Roul G. , Philippe C. , Watterson D.M. , Haiech J. , Andriantsitohaina R.
Am. J. Physiol.289:H2342-H2349(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
9.

"Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo."
Clayburgh D.R. , Barrett T.A. , Tang Y. , Meddings J.B. , Van Eldik L.J. , Watterson D.M. , Clarke L.L. , Mrsny R.J. , Turner J.R.
J. Clin. Invest.115:2702-2715(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN INTESTINAL BARRIER DYSFUNCTION
10.

"Supervillin slows cell spreading by facilitating myosin II activation at the cell periphery."
Takizawa N. , Ikebe R. , Ikebe M. , Luna E.J.
J. Cell Sci.120:3792-3803(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SVIL
11.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-355; SER-1782 AND SER-1798;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
12.

"A role for long chain myosin light chain kinase (MLCK-210) in microvascular hyperpermeability during severe burns."
Reynoso R. , Perrin R.M. , Breslin J.W. , Daines D.A. , Watson K.D. , Watterson D.M. , Wu M.H. , Yuan S.
Shock28:589-595(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MICROVASCULAR HYPERPERMEABILITY DURING SEVERE BURNS;DISRUPTION PHENOTYPE
13.

"Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice."
He W.-Q. , Peng Y.-J. , Zhang W.-C. , Lv N. , Tang J. , Chen C. , Zhang C.-H. , Gao S. , Chen H.-Q. , Zhi G. , Feil R. , Kamm K.E. , Stull J.T. , Gao X. , Zhu M.-S.
Gastroenterology135:610-620(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SMOOTH MUSCLE CONTRACTION
14.

"Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins."
Xu J. , Gao X.-P. , Ramchandran R. , Zhao Y.-Y. , Vogel S.M. , Malik A.B.
Nat. Immunol.9:880-886(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS PTK2B/PYK2 KINASE;INTERACTION WITH PTK2B/PYK2
15.

"A family of protein-deglutamylating enzymes associated with neurodegeneration."
Rogowski K. , van Dijk J. , Magiera M.M. , Bosc C. , Deloulme J.C. , Bosson A. , Peris L. , Gold N.D. , Lacroix B. , Grau M.B. , Bec N. , Larroque C. , Desagher S. , Holzer M. , Andrieux A. , Moutin M.J. , Janke C.
Cell143:564-578(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEGLUTAMYLATION
16.

"Myosin light chain kinase is necessary for tonic airway smooth muscle contraction."
Zhang W.-C. , Peng Y.-J. , Zhang G.-S. , He W.-Q. , Qiao Y.-N. , Dong Y.-Y. , Gao Y.-Q. , Chen C. , Zhang C.-H. , Li W. , Shen H.-H. , Ning W. , Kamm K.E. , Stull J.T. , Gao X. , Zhu M.-S.
J. Biol. Chem.285:5522-5531(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TONIC AIRWAY SMOOTH MUSCLE CONTRACTION
17.

"MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function."
Yu D. , Marchiando A.M. , Weber C.R. , Raleigh D.R. , Wang Y. , Shen L. , Turner J.R.
Proc. Natl. Acad. Sci. U.S.A.107:8237-8241(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TIGHT JUNCTION REGULATION

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