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Index > Protein center > NFX1(Gene name) > Human
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  • NFX1 (Gene name),
  • Transcriptional repressor NF-X1 (Protein name ),  NFX1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    NFX1(NFX2);
    Protein name:
    Transcriptional repressor NF-X1;
    Alternative:
    Nuclear transcription factor, X box-binding protein 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Isoform 1 and isoform 3 interact with human papillomavirus (HPV) type-16 E6 oncoprotein. Isoform 1 interacts with PABPC1 and PABPC4.
    Function:
    Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    1120
    Sequence:
    50:
    MAEAPPVSGT | FKFNTDAAEF | IPQEKKNSGL | NCGTQRRLDS | NRIGRRNYSS | 
    100:
    PPPCHLSRQV | PYDEISAVHQ | HSYHPSGSKP | KSQQTSFQSS | PCNKSPKSHG | 
    150:
    LQNQPWQKLR | NEKHHIRVKK | AQSLAEQTSD | TAGLESSTRS | ESGTDLREHS | 
    200:
    PSESEKEVVG | ADPRGAKPKK | ATQFVYSYGR | GPKVKGKLKC | EWSNRTTPKP | 
    250:
    EDAGPESTKP | VGVFHPDSSE | ASSRKGVLDG | YGARRNEQRR | YPQKRPPWEV | 
    300:
    EGARPRPGRN | PPKQEGHRHT | NAGHRNNMGP | IPKDDLNERP | AKSTCDSENL | 
    350:
    AVINKSSRRV | DQEKCTVRRQ | DPQVVSPFSR | GKQNHVLKNV | ETHTGSLIEQ | 
    400:
    LTTEKYECMV | CCELVRVTAP | VWSCQSCYHV | FHLNCIKKWA | RSPASQADGQ | 
    450:
    SGWRCPACQN | VSAHVPNTYT | CFCGKVKNPE | WSRNEIPHSC | GEVCRKKQPG | 
    500:
    QDCPHSCNLL | CHPGPCPPCP | AFMTKTCECG | RTRHTVRCGQ | AVSVHCSNPC | 
    550:
    ENILNCGQHQ | CAELCHGGQC | QPCQIILNQV | CYCGSTSRDV | LCGTDVGKSD | 
    600:
    GFGDFSCLKI | CGKDLKCGNH | TCSQVCHPQP | CQQCPRLPQL | VRCCPCGQTP | 
    650:
    LSQLLELGSS | SRKTCMDPVP | SCGKVCGKPL | PCGSLDFIHT | CEKLCHEGDC | 
    700:
    GPCSRTSVIS | CRCSFRTKEL | PCTSLKSEDA | TFMCDKRCNK | KRLCGRHKCN | 
    750:
    EICCVDKEHK | CPLICGRKLR | CGLHRCEEPC | HRGNCQTCWQ | ASFDELTCHC | 
    800:
    GASVIYPPVP | CGTRPPECTQ | TCARVHECDH | PVYHSCHSEE | KCPPCTFLTQ | 
    850:
    KWCMGKHEFR | SNIPCHLVDI | SCGLPCSATL | PCGMHKCQRL | CHKGECLVDE | 
    900:
    PCKQPCTTPR | ADCGHPCMAP | CHTSSPCPVT | ACKAKVELQC | ECGRRKEMVI | 
    950:
    CSEASSTYQR | IAAISMASKI | TDMQLGGSVE | ISKLITKKEV | HQARLECDEE | 
    1000:
    CSALERKKRL | AEAFHISEDS | DPFNIRSSGS | KFSDSLKEDA | RKDLKFVSDV | 
    1050:
    EKEMETLVEA | VNKGKNSKKS | HSFPPMNRDH | RRIIHDLAQV | YGLESVSYDS | 
    1100:
    EPKRNVVVTA | IRGKSVCPPT | TLTGVLEREM | QARPPPPIPH | HRHQSDKNPG | 
    1120:
    SSNLQKITKE | PIIDYFDVQD | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    Pfam:
    SMR:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Transcriptional repressor NF-X1
    ELISA Kit for Human Transcriptional repressor NF-X1
    ELISA Kit for Human Transcriptional repressor NF-X1
    CLIA Kit for Human Transcriptional repressor NF-X1
    CLIA Kit for Human Transcriptional repressor NF-X1
    CLIA Kit for Human Transcriptional repressor NF-X1
    Polyclonal Antibody for Human Transcriptional repressor NF-X1
    Polyclonal Antibody for Human Transcriptional repressor NF-X1
    Polyclonal Antibody for Human Transcriptional repressor NF-X1
    Monoclonal Antibody for Human Transcriptional repressor NF-X1
    Monoclonal Antibody for Human Transcriptional repressor NF-X1
    Monoclonal Antibody for Human Transcriptional repressor NF-X1
    Protein for Human Transcriptional repressor NF-X1
    Protein for Human Transcriptional repressor NF-X1
    Protein for Human Transcriptional repressor NF-X1

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    References
    1. 1.
      Li J.M. , Sah J.H. , Zhou Z.M.
      Submitted (2000-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Testis.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Placenta.
    3. 3.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Eye.
    6. 6.
      "A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor."
      Song Z. , Krishna S. , Thanos D. , Strominger J.L. , Ono S.J.
      J. Exp. Med.180:1763-1774(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 48-1120 (ISOFORM 1)
    7. 7.
      "RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination."
      Lorick K.L. , Jensen J.P. , Fang S. , Ong A.M. , Hatakeyama S. , Weissman A.M.
      Proc. Natl. Acad. Sci. U.S.A.96:11364-11369(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS AN E2-DEPENDENT UBIQUITIN-PROTEIN LIGASE
    8. 8.
      "Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex."
      Gewin L. , Myers H. , Kiyono T. , Galloway D.A.
      Genes Dev.18:2269-2282(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HPV16 E6;FUNCTION
    9. 9.
      "NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells."
      Katzenellenbogen R.A. , Egelkrout E.M. , Vliet-Gregg P. , Gewin L.C. , Gafken P.R. , Galloway D.A.
      J. Virol.81:3786-3796(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PABPC1 AND PABPC4;MUTAGENESIS OF PHE-20
    10. 10.
      "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
      J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 12.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 14.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
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