Protein name:
Transcriptional repressor NF-X1 ;
Alternative:
Nuclear transcription factor, X box-binding protein 1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Isoform 1 and isoform 3 interact with human papillomavirus (HPV) type-16 E6 oncoprotein. Isoform 1 interacts with PABPC1 and PABPC4.
Function:
Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MAEAPPVSGT | FKFNTDAAEF | IPQEKKNSGL | NCGTQRRLDS | NRIGRRNYSS |
100:
PPPCHLSRQV | PYDEISAVHQ | HSYHPSGSKP | KSQQTSFQSS | PCNKSPKSHG |
150:
LQNQPWQKLR | NEKHHIRVKK | AQSLAEQTSD | TAGLESSTRS | ESGTDLREHS |
200:
PSESEKEVVG | ADPRGAKPKK | ATQFVYSYGR | GPKVKGKLKC | EWSNRTTPKP |
250:
EDAGPESTKP | VGVFHPDSSE | ASSRKGVLDG | YGARRNEQRR | YPQKRPPWEV |
300:
EGARPRPGRN | PPKQEGHRHT | NAGHRNNMGP | IPKDDLNERP | AKSTCDSENL |
350:
AVINKSSRRV | DQEKCTVRRQ | DPQVVSPFSR | GKQNHVLKNV | ETHTGSLIEQ |
400:
LTTEKYECMV | CCELVRVTAP | VWSCQSCYHV | FHLNCIKKWA | RSPASQADGQ |
450:
SGWRCPACQN | VSAHVPNTYT | CFCGKVKNPE | WSRNEIPHSC | GEVCRKKQPG |
500:
QDCPHSCNLL | CHPGPCPPCP | AFMTKTCECG | RTRHTVRCGQ | AVSVHCSNPC |
550:
ENILNCGQHQ | CAELCHGGQC | QPCQIILNQV | CYCGSTSRDV | LCGTDVGKSD |
600:
GFGDFSCLKI | CGKDLKCGNH | TCSQVCHPQP | CQQCPRLPQL | VRCCPCGQTP |
650:
LSQLLELGSS | SRKTCMDPVP | SCGKVCGKPL | PCGSLDFIHT | CEKLCHEGDC |
700:
GPCSRTSVIS | CRCSFRTKEL | PCTSLKSEDA | TFMCDKRCNK | KRLCGRHKCN |
750:
EICCVDKEHK | CPLICGRKLR | CGLHRCEEPC | HRGNCQTCWQ | ASFDELTCHC |
800:
GASVIYPPVP | CGTRPPECTQ | TCARVHECDH | PVYHSCHSEE | KCPPCTFLTQ |
850:
KWCMGKHEFR | SNIPCHLVDI | SCGLPCSATL | PCGMHKCQRL | CHKGECLVDE |
900:
PCKQPCTTPR | ADCGHPCMAP | CHTSSPCPVT | ACKAKVELQC | ECGRRKEMVI |
950:
CSEASSTYQR | IAAISMASKI | TDMQLGGSVE | ISKLITKKEV | HQARLECDEE |
1000:
CSALERKKRL | AEAFHISEDS | DPFNIRSSGS | KFSDSLKEDA | RKDLKFVSDV |
1050:
EKEMETLVEA | VNKGKNSKKS | HSFPPMNRDH | RRIIHDLAQV | YGLESVSYDS |
1100:
EPKRNVVVTA | IRGKSVCPPT | TLTGVLEREM | QARPPPPIPH | HRHQSDKNPG |
1120:
SSNLQKITKE | PIIDYFDVQD |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Mouse
Human
ELISA Kit for Human Transcriptional repressor NF-X1
ELISA Kit for Human Transcriptional repressor NF-X1
ELISA Kit for Human Transcriptional repressor NF-X1
CLIA Kit for Human Transcriptional repressor NF-X1
CLIA Kit for Human Transcriptional repressor NF-X1
CLIA Kit for Human Transcriptional repressor NF-X1
Polyclonal Antibody for Human Transcriptional repressor NF-X1
Polyclonal Antibody for Human Transcriptional repressor NF-X1
Polyclonal Antibody for Human Transcriptional repressor NF-X1
Monoclonal Antibody for Human Transcriptional repressor NF-X1
Monoclonal Antibody for Human Transcriptional repressor NF-X1
Monoclonal Antibody for Human Transcriptional repressor NF-X1
Protein for Human Transcriptional repressor NF-X1
Protein for Human Transcriptional repressor NF-X1
Protein for Human Transcriptional repressor NF-X1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Eye .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 48-1120 (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH PABPC1 AND PABPC4;MUTAGENESIS OF PHE-20
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .