Gene name:
NLRX1 (NOD26;NOD5;NOD9) ;
Protein name:
NLR family member X1 ;
Alternative:
Nucleotide-binding oligomerization domain protein 26 ;Caterpiller protein 11.3 (CLR11.3) ;Nucleotide-binding oligomerization domain protein 9 ;Nucleotide-binding oligomerization domain protein 5 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with MAVS.
Function:
Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).
Subcellular Location:
Mitochondrion outer membrane
Protein Attributes:
50:
MRWGHHLPRA | SWGSGFRRAL | QRPDDRIPFL | IHWSWPLQGE | RPFGPPRAFI |
100:
RHHGSSVDSA | PPPGRHGRLF | PSASATEAIQ | RHRRNLAEWF | SRLPREERQF |
150:
GPTFALDTVH | VDPVIRESTP | DELLRPPAEL | ALEHQPPQAG | LPPLALSQLF |
200:
NPDACGRRVQ | TVVLYGTVGT | GKSTLVRKMV | LDWCYGRLPA | FELLIPFSCE |
250:
DLSSLGPAPA | SLCQLVAQRY | TPLKEVLPLM | AAAGSHLLFV | LHGLEHLNLD |
300:
FRLAGTGLCS | DPEEPQEPAA | IIVNLLRKYM | LPQASILVTT | RPSAIGRIPS |
350:
KYVGRYGEIC | GFSDTNLQKL | YFQLRLNQPY | CGYAVGGSGV | SATPAQRDHL |
400:
VQMLSRNLEG | HHQIAAACFL | PSYCWLVCAT | LHFLHAPTPA | GQTLTSIYTS |
450:
FLRLNFSGET | LDSTDPSNLS | LMAYAARTMG | KLAYEGVSSR | KTYFSEEDVC |
500:
GCLEAGIRTE | EEFQLLHIFR | RDALRFFLAP | CVEPGRAGTF | VFTVPAMQEY |
550:
LAALYIVLGL | RKTTLQKVGK | EVAELVGRVG | EDVSLVLGIM | AKLLPLRALP |
600:
LLFNLIKVVP | RVFGRMVGKS | REAVAQAMVL | EMFREEDYYN | DDVLDQMGAS |
650:
ILGVEGPRRH | PDEPPEDEVF | ELFPMFMGGL | LSAHNRAVLA | QLGCPIKNLD |
700:
ALENAQAIKK | KLGKLGRQVL | PPSELLDHLF | FHYEFQNQRF | SAEVLSSLRQ |
750:
LNLAGVRMTP | VKCTVVAAVL | GSGRHALDEV | NLASCQLDPA | GLRTLLPVFL |
800:
RARKLGLQLN | SLGPEACKDL | RDLLLHDQCQ | ITTLRLSNNP | LTAAGVAVLM |
850:
EGLAGNTSVT | HLSLLHTGLG | DEGLELLAAQ | LDRNRQLQEL | NVAYNGAGDT |
900:
AALALARAAR | EHPSLELLHL | YFNELSSEGR | QVLRDLGGAA | EGGARVVVSL |
950:
TEGTAVSEYW | SVILSEVQRN | LNSWDRARVQ | RHLELLLRDL | EDSRGATLNP |
975:
WRKAQLLRVE | GEVRALLEQL | GSSGS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
ELISA Kit for Human NLR family member X1
ELISA Kit for Human NLR family member X1
ELISA Kit for Human NLR family member X1
CLIA Kit for Human NLR family member X1
CLIA Kit for Human NLR family member X1
CLIA Kit for Human NLR family member X1
Polyclonal Antibody for Human NLR family member X1
Polyclonal Antibody for Human NLR family member X1
Polyclonal Antibody for Human NLR family member X1
Monoclonal Antibody for Human NLR family member X1
Monoclonal Antibody for Human NLR family member X1
Monoclonal Antibody for Human NLR family member X1
Protein for Human NLR family member X1
Protein for Human NLR family member X1
Protein for Human NLR family member X1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS SER-63 AND GLU-793
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS SER-63 AND GLU-793
tissue :
Colon .
tissue :
Placenta .
tissue :
Tongue .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 214-975 (ISOFORM 2);VARIANT GLU-793
tissue :
Bone .
tissue :
Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
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Nature451:573-577(2008)
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH MAVS;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 629-975;LRR REPEATS;SUBUNIT