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Index > Protein center > Fam105b(Gene name) > Mouse
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  • Fam105b (Gene name),
  • Ubiquitin thioesterase otulin (Protein name ),  OTUL_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Fam105b(Gum);
    Protein name:
    Ubiquitin thioesterase otulin;
    Alternative:
    OTU domain-containing deubiquitinase with linear linkage specificity;Deubiquitinating enzyme otulin;Ubiquitin thioesterase Gumby;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with RNF31; the interaction is direct. Interacts with DVL2.
    Function:
    Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex. Plays a key role in innate immune response: required to restrict linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    352
    Sequence:
    50:
    MSRGTMPQPG | AWPGASCAET | PAREAGAAAR | DGGKVTAGAQ | PRAATRCPAE | 
    100:
    HEEDMYRAAD | EIEKEKELLI | HERGISEPRL | SVAPEMDIMD | YCKKEWRGNT | 
    150:
    QKATCMKKGY | EEVSQKFTSI | RRVRGDNYCA | LRATLFQAMS | QLAELPPWLQ | 
    200:
    DLELILLPEK | LINKYTWIKQ | WKLGLKFDGK | SEDLVEKIKE | SLALLRKKWV | 
    250:
    SLAAMKTAEA | RQTACDELFT | NEEEEYSLYE | AVKFLMLNRA | IELYDDKEKG | 
    300:
    KEVPFFSVLL | FARDTSNDPE | QLLRNHLNQV | GHTGGLEQVE | MFLLAYAVRH | 
    350:
    SIRVYRLSKY | NTEEFITVYP | TDPPKDWPMV | TLIAEDDRHY | NIPVRVCEET | 
    352:
    SV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Ubiquitin thioesterase otulin
    Cat.:
    E15311m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Ubiquitin thioesterase otulin
    Cat.:
    E15311m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Ubiquitin thioesterase otulin
    Cat.:
    E15311h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Ubiquitin thioesterase otulin
    Cat.:
    E15311h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Ubiquitin thioesterase otulin
    Cat.:
    U15311h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Ubiquitin thioesterase otulin
    Cat.:
    U15311h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Ubiquitin thioesterase otulin
    Cat.:
    U15311m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Ubiquitin thioesterase otulin
    Cat.:
    U15311m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Ubiquitin thioesterase otulin
    Cat.:
    P15311Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Ubiquitin thioesterase otulin
    Cat.:
    P15311Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Ubiquitin thioesterase otulin
    Cat.:
    P15311Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Ubiquitin thioesterase otulin
    Cat.:
    P15311Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Ubiquitin thioesterase otulin
    Monoclonal Antibody for Mouse Ubiquitin thioesterase otulin
    Monoclonal Antibody for Mouse Ubiquitin thioesterase otulin
    Monoclonal Antibody for Mouse Ubiquitin thioesterase otulin
    Protein for Mouse Ubiquitin thioesterase otulin
    Protein for Mouse Ubiquitin thioesterase otulin
    Protein for Mouse Ubiquitin thioesterase otulin
    Protein for Mouse Ubiquitin thioesterase otulin

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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Bone marrow.
      tissue: Olfactory bulb.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 106-352
      tissue: Mammary gland.
      tissue: Molar.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE;ACTIVE SITE;INTERACTION WITH RNF31 AND DVL2;MUTAGENESIS OF TRP-96; CYS-129; ASP-336 AND 349-GLU--VAL-352
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