PRDX1 ELISA Kit for Human(Homo sapiens) | EIAab.comPRDX1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > PRDX1(Gene name) > Human

PRDX1 (Gene name),

Peroxiredoxin-1 (Protein name ), PRDX1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

PRDX1(PAGA;PAGB;TDPX2);

Protein name:

Peroxiredoxin-1;

Alternative:

Proliferation-associated gene protein(PAG);Natural killer cell-enhancing factor A(NKEF-A);Thioredoxin-dependent peroxide reductase 2;Thioredoxin peroxidase 2;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer; disulfide-linked, upon oxidation (By similarity). May form heterodimers with AOP2. Interacts with GDPD5; forms a mixed-disulfide with GDPD5.

Function:

Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation.

Subcellular Location:

Cytoplasm Melanosome Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Protein Attributes:

Sequence length:

199

Sequence:

50:

100:

150:

199:

RSVDETLRLV | QAFQFTDKHG | EVCPAGWKPG | SDTIKPDVQK | SKEYFSKQK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.180909

STRING:

9606.ENSP00000262746

KEGG:

hsa:5052

MIM:

176763

Pfam:

PF10417

String:

Q06830

SMR:

Q06830

Uniprot:

Q06830

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ELISA Kit for Human Peroxiredoxin-1

Cat.:

E2222m

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96T

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ELISA Kit for Human Peroxiredoxin-1

Cat.:

E2222h

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96T

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ELISA Kit for Human Peroxiredoxin-1

Cat.:

E2222c

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96T

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ELISA Kit for Human Peroxiredoxin-1

Cat.:

E2222b

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96T

ELISA Kit for Human Peroxiredoxin-1

Cat.:

E2222r

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96T

CLIA Kit for Human Peroxiredoxin-1

Cat.:

U2222b

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96T

CLIA Kit for Human Peroxiredoxin-1

Cat.:

U2222c

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Packing:

96T

CLIA Kit for Human Peroxiredoxin-1

Cat.:

U2222m

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MSDS:

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Packing:

96T

CLIA Kit for Human Peroxiredoxin-1

Cat.:

U2222h

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Looking for manual.

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Packing:

96T

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CLIA Kit for Human Peroxiredoxin-1

Cat.:

U2222r

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96T

Polyclonal Antibody for Human Peroxiredoxin-1

Cat.:

P2222Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Peroxiredoxin-1

Cat.:

P2222Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Peroxiredoxin-1

Cat.:

P2222Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human Peroxiredoxin-1

Protein for Human Peroxiredoxin-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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Citations

[1].

"Differential associations of circulating peroxiredoxins levels with indicators of glycemic control in type 2 diabetes mellitus"

AA Al-Masri, E El Eter, S Tayel, et al.

From:Eur Rev Med Pharmacol Sci

References

1.

"A human cDNA corresponding to a gene overexpressed during cell proliferation encodes a product sharing homology with amoebic and bacterial proteins."
Prosperi M.T. , Ferbus D. , Karczinski I. , Goubin G.
J. Biol. Chem.268:11050-11056(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Cloning and sequence analysis of candidate human natural killer-enhancing factor genes."
Shau H. , Butterfield L.H. , Chiu R. , Kim A.
Immunogenetics40:129-134(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2004-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

NIEHS SNPs program
Submitted (2005-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLY-62
6.

"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Goshima N. , Kawamura Y. , Fukumoto A. , Miura A. , Honma R. , Satoh R. , Wakamatsu A. , Yamamoto J. , Kimura K. , Nishikawa T. , Andoh T. , Iida Y. , Ishikawa K. , Ito E. , Kagawa N. , Kaminaga C. , Kanehori K. , Kawakami B. , more...
Nat. Methods5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
7.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Urinary bladder.
10.

Lubec G. , Afjehi-Sadat L. , Chen W.-Q. , Sun Y.
Submitted (2008-12) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 17-35; 93-136; 141-151 AND 159-190;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Brain.
tissue: Cajal-Retzius cell.
tissue: Fetal brain cortex.
11.

"A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress."
Wagner E. , Luche S. , Penna L. , Chevallet M. , van Dorsselaer A. , Leize-Wagner E. , Rabilloud T.
Biochem. J.366:777-785(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: OVEROXIDATION AT CYS-52
12.

"Regulation of peroxiredoxin I activity by Cdc2-mediated phosphorylation."
Chang T.-S. , Jeong W. , Choi S.Y. , Yu S. , Kang S.W. , Rhee S.G.
J. Biol. Chem.277:25370-25376(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-90;MUTAGENESIS OF THR-90
13.

"Inactivation of human peroxiredoxin I during catalysis as the result of the oxidation of the catalytic site cysteine to cysteine-sulfinic acid."
Yang K.S. , Kang S.W. , Woo H.A. , Hwang S.C. , Chae H.Z. , Kim K. , Rhee S.G.
J. Biol. Chem.277:38029-38036(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: OVEROXIDATION AT CYS-52
14.

"Regeneration of peroxiredoxins during recovery after oxidative stress: only some overoxidized peroxiredoxins can be reduced during recovery after oxidative stress."
Chevallet M. , Wagner E. , Luche S. , van Dorsselaer A. , Leize-Wagner E. , Rabilloud T.
J. Biol. Chem.278:37146-37153(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RETROREDUCTION OF CYS-52;IDENTIFICATION BY MASS SPECTROMETRY
15.

"Reversing the inactivation of peroxiredoxins caused by cysteine sulfinic acid formation."
Woo H.A. , Chae H.Z. , Hwang S.C. , Yang K.S. , Kang S.W. , Kim K. , Rhee S.G.
Science300:653-656(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RETROREDUCTION OF CYS-52;IDENTIFICATION BY MASS SPECTROMETRY
16.

"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."
Chi A. , Valencia J.C. , Hu Z.-Z. , Watabe H. , Yamaguchi H. , Mangini N.J. , Huang H. , Canfield V.A. , Cheng K.C. , Yang F. , Abe R. , Yamagishi S. , Shabanowitz J. , Hearing V.J. , Wu C. , Appella E. , Hunt D.F.
J. Proteome Res.5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
tissue: Melanoma.
17.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2; LYS-7; LYS-16; LYS-27 AND LYS-35;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
18.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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