RIP-like protein kinase 3;Homocysteine respondent protein HCYP2;Receptor-interacting protein 3(RIP-3);
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts (via RIP homotypic interaction motif) with RIPK1 (via RIP homotypic interaction motif); this interaction induces RIPK1 phosphorylation and formation of a RIPK1-RIPK3 necroptosis-inducing complex. Binds TRAF2 is recruited to the TNFR-1 signaling complex. Interacts with PYGL, GLUL and GLUD1; these interactions result in activation of these metabolic enzymes.
Function:
Essential for cellular necroptosis in response to TNF-alpha family of death-inducing cytokines. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
Monoclonal Antibody for Rat Receptor-interacting serine/threonine-protein kinase 3
Monoclonal Antibody for Rat Receptor-interacting serine/threonine-protein kinase 3
Monoclonal Antibody for Rat Receptor-interacting serine/threonine-protein kinase 3
Protein for Rat Receptor-interacting serine/threonine-protein kinase 3
Protein for Rat Receptor-interacting serine/threonine-protein kinase 3
Protein for Rat Receptor-interacting serine/threonine-protein kinase 3
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"A homocysteine-respondent gene cloned from WKY VSMCs by differential display." Chen K.H.
,
Tang J.
Submitted (2001-05) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA]