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Index > Protein center > SFSWAP(Gene name) > Human
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  • SFSWAP (Gene name),
  • Splicing factor, suppressor of white-apricot homolog (Protein name ),  SFSWA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SFSWAP(SFRS8;SWAP);
    Protein name:
    Splicing factor, suppressor of white-apricot homolog;
    Alternative:
    Suppressor of white apricot protein homolog;Splicing factor, arginine/serine-rich 8;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    951
    Sequence:
    50:
    MYGASGGRAK | PERKSGAKEE | AGPGGAGGGG | SRVELLVFGY | ACKLFRDDER | 
    100:
    ALAQEQGQHL | IPWMGDHKIL | IDRYDGRGHL | HDLSEYDAEY | STWNRDYQLS | 
    150:
    EEEARIEALC | DEERYLALHT | DLLEEEARQE | EEYKRLSEAL | AEDGSYNAVG | 
    200:
    FTYGSDYYDP | SEPTEEEEPS | KQREKNEAEN | LEENEEPFVA | PLGLSVPSDV | 
    250:
    ELPPTAKMHA | IIERTASFVC | RQGAQFEIML | KAKQARNSQF | DFLRFDHYLN | 
    300:
    PYYKFIQKAM | KEGRYTVLAE | NKSDEKKKSG | VSSDNEDDDD | EEDGNYLHPS | 
    350:
    LFASKKCNRL | EELMKPLKVV | DPDHPLAALV | RKAQADSSTP | TPHNADGAPV | 
    400:
    QPSQVEYTAD | STVAAMYYSY | YMLPDGTYCL | APPPPGIDVT | TYYSTLPAGV | 
    450:
    TVSNSPGVTT | TAPPPPGTTP | LPPPTTAETS | SGATSTTTTT | SALAPVAAII | 
    500:
    PPPPDVQPVI | DKLAEYVARN | GLKFETSVRA | KNDQRFEFLQ | PWHQYNAYYE | 
    550:
    FKKQFFLQKE | GGDSMQAVSA | PEEAPTDSAP | EKPSDAGEDG | APEDAAEVGA | 
    600:
    RAGSGGKKEA | SSSKTVPDGK | LVKASFAPIS | FAIKAKENDL | LPLEKNRVKL | 
    650:
    DDDSDDDEES | KEGQESSSSA | ANTNPAVAPP | CVVVEEKKPQ | LTQEELEAKQ | 
    700:
    AKQKLEDRLA | AAAREKLAQA | SKESKEKQLQ | AERKRKAALF | LQTLKNPLPE | 
    750:
    AEAGKIEESP | FSVEESSTTP | CPLLTGGRPL | PTLEVKPPDR | PSSKSKDPPR | 
    800:
    EEEKEKKKKK | HKKRSRTRSR | SPKYHSSSKS | RSRSHSKAKH | SLPSAYRTVR | 
    850:
    RSRSRSRSPR | RRAHSPERRR | EERSVPTAYR | VSRSPGASRK | RTRSRSPHEK | 
    900:
    KKKRRSRSRT | KSKARSQSVS | PSKQAAPRPA | APAAHSAHSA | SVSPVESRGS | 
    950:
    SQERSRGVSQ | EKEAQISSAI | VSSVQSKITQ | DLMAKVRAML | AASKNLQTSA | 
    951:
    S
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    MIM:
    KEGG:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Splicing factor, suppressor of white-apricot homolog
    ELISA Kit for Human Splicing factor, suppressor of white-apricot homolog
    ELISA Kit for Human Splicing factor, suppressor of white-apricot homolog
    CLIA Kit for Human Splicing factor, suppressor of white-apricot homolog
    CLIA Kit for Human Splicing factor, suppressor of white-apricot homolog
    CLIA Kit for Human Splicing factor, suppressor of white-apricot homolog
    Polyclonal Antibody for Human Splicing factor, suppressor of white-apricot homolog
    Polyclonal Antibody for Human Splicing factor, suppressor of white-apricot homolog
    Polyclonal Antibody for Human Splicing factor, suppressor of white-apricot homolog
    Monoclonal Antibody for Human Splicing factor, suppressor of white-apricot homolog
    Monoclonal Antibody for Human Splicing factor, suppressor of white-apricot homolog
    Monoclonal Antibody for Human Splicing factor, suppressor of white-apricot homolog
    Protein for Human Splicing factor, suppressor of white-apricot homolog
    Protein for Human Splicing factor, suppressor of white-apricot homolog
    Protein for Human Splicing factor, suppressor of white-apricot homolog

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Conservation of regulated alternative splicing and identification of functional domains in vertebrate homologs to the Drosophila splicing regulator, suppressor-of-white-apricot."
      Denhez F. , Lafyatis R.
      J. Biol. Chem.269:16170-16179(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS GLN-52; PHE-136 AND PRO-421
      tissue: Placenta.
    2. 2.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT PRO-421
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT PRO-421
      tissue: Brain.
      tissue: Skin.
    5. 5.
      "The mammalian homolog of suppressor-of-white-apricot regulates alternative mRNA splicing of CD45 exon 4 and fibronectin IIICS."
      Sarkissian M. , Winne A. , Lafyatis R.
      J. Biol. Chem.271:31106-31114(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    6. 6.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    7. 7.
      "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
      Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
      Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-642;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic kidney.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283; SER-604 AND SER-909;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283 AND SER-909;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    11. 11.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-315;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-604;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 13.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-604;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 14.
      "Solution structure of the SURP1 and SURP2 domain in splicing factor, arginine/serine-rich 8."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2007-06) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 189-282 AND 434-522
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