Shank3 ELISA Kit for Mouse(Mus musculus) | EIAab.comShank3 ELISA Kit for Mouse(Mus musculus)

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Shank3 (Gene name),

SH3 and multiple ankyrin repeat domains protein 3 (Protein name ), SHAN3_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Shank3(Kiaa1650;Prosap2);

Protein name:

SH3 and multiple ankyrin repeat domains protein 3(Shank3);

Alternative:

SPANK-2;Proline-rich synapse-associated protein 2(ProSAP2);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

May homomultimerize via its SAM domain. Interacts with BAIAP2 (By similarity). Interacts with DLGAP1/GKAP, MGLUR1A and MGLUR5 C-termini via its PDZ domain. Interacts (via PDZ domain) with PROSAPIP1 (via C-terminus) (By similarity). Interacts with HOMER1, HOMER2, HOMER3 and CCTN/cortactin SH3 domain (By similarity). Is part of a complex with DLG4/PSD-95 and DLGAP1/GKAP (By similarity). Interacts with DBNL. Interacts with the GRIA1 subunit of AMPA receptor through the SH3-PDZ domain.

Function:

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.

Subcellular Location:

Cytoplasm Cell junction synapse Cell junction synapse postsynaptic cell membrane postsynaptic density Postsynaptic density of neuronal cells. Extends into the region subjacent to the PSD.

Protein Attributes:

Sequence length:

1805

Sequence:

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1450:

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1650:

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1750:

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1805:

QLDGS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q4ACU6

KEGG:

mmu:58234

UniGene:

Mm.146855

SMR:

Q4ACU6

Pfam:

PF12796

Uniprot:

Q4ACU6

FOR

ELISA Kit for Mouse Shank3

CLIA Kit for Mouse Shank3

Polyclonal Antibody for Mouse Shank3

Monoclonal Antibody for Mouse Shank3

Protein for Mouse Shank3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Interaction of the Na+/Phosphate cotransporter type II with rSHANK."
Dehmelt L. , Nalbant P. , Werner A.
Submitted (1999-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
strain: C57B16/J.
tissue: Kidney.
2.

"Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor."
Uchino S. , Wada H. , Honda S. , Nakamura Y. , Ondo Y. , Uchiyama T. , Tsutsumi M. , Suzuki E. , Hirasawa T. , Kohsaka S.
J. Neurochem.97:1203-1214(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH GRIA1;SUBCELLULAR LOCATION
3.

"Identification of two novel Shank3 transcripts in the developing mouse neocortex."
Waga C. , Asano H. , Sanagi T. , Suzuki E. , Nakamura Y. , Tsuchiya A. , Itoh M. , Goto Y.I. , Kohsaka S. , Uchino S.
J. Neurochem.128:280-293(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4);ALTERNATIVE SPLICING;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE
4.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
5.

"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Koseki H. , Hiraoka S. , Saga Y. , Seino S. , Nishimura M. , Kaisho T. , Hoshino K. , Kitamura H. , Nagase T. , Ohara O. , Koga H.
DNA Res.11:205-218(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 875-1730
tissue: Brain.
6.

"Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3."
Wang X. , McCoy P.A. , Rodriguiz R.M. , Pan Y. , Je H.S. , Roberts A.C. , Kim C.J. , Berrios J. , Colvin J.S. , Bousquet-Moore D. , Lorenzo I. , Wu G. , Weinberg R.J. , Ehlers M.D. , Philpot B.D. , Beaudet A.L. , Wetsel W.C. , Jiang Y.H.
Hum. Mol. Genet.20:3093-3108(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 6; 7; 8 AND 9);ALTERNATIVE SPLICING;FUNCTION;DISRUPTION PHENOTYPE;TISSUE SPECIFICITY;INTERACTION WITH HOMER1
7.

"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C. , Specht C.G. , Thalhammer A. , Schoepfer R. , Burlingame A.L.
Mol. Cell. Proteomics5:914-922(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-482;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Brain.
8.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1634;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
9.

"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
Ballif B.A. , Carey G.R. , Sunyaev S.R. , Gygi S.P.
J. Proteome Res.7:311-318(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-122 AND TYR-555;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Brain.
10.

"Conserved role of intragenic DNA methylation in regulating alternative promoters."
Maunakea A.K. , Nagarajan R.P. , Bilenky M. , Ballinger T.J. , D'Souza C. , Fouse S.D. , Johnson B.E. , Hong C. , Nielsen C. , Zhao Y. , Turecki G. , Delaney A. , Varhol R. , Thiessen N. , Shchors K. , Heine V.M. , Rowitch D.H. , Xing X. , more...
Nature466:253-257(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE PROMOTER USAGE
11.

"Shank3 mutant mice display autistic-like behaviours and striatal dysfunction."
Peca J. , Feliciano C. , Ting J.T. , Wang W. , Wells M.F. , Venkatraman T.N. , Lascola C.D. , Fu Z. , Feng G.
Nature472:437-442(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;TISSUE SPECIFICITY
12.

"Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2."
Schmeisser M.J. , Ey E. , Wegener S. , Bockmann J. , Stempel A.V. , Kuebler A. , Janssen A.L. , Udvardi P.T. , Shiban E. , Spilker C. , Balschun D. , Skryabin B.V. , Dieck S.T. , Smalla K.H. , Montag D. , Leblond C.S. , Faure P. , Torquet N. , more...
Nature486:256-260(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
13.

"Shank3-Rich2 interaction regulates AMPA receptor recycling and synaptic long-term potentiation."
Raynaud F. , Janossy A. , Dahl J. , Bertaso F. , Perroy J. , Varrault A. , Vidal M. , Worley P.F. , Boeckers T.M. , Bockaert J. , Marin P. , Fagni L. , Homburger V.
J. Neurosci.33:9699-9715(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN AMPA RECEPTOR SIGNALING;INTERACTION WITH ARHGAP44
14.

"Loss of predominant shank3 isoforms results in hippocampus-dependent impairments in behavior and synaptic transmission."
Kouser M. , Speed H.E. , Dewey C.M. , Reimers J.M. , Widman A.J. , Gupta N. , Liu S. , Jaramillo T.C. , Bangash M. , Xiao B. , Worley P.F. , Powell C.M.
J. Neurosci.33:18448-18468(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
15.

"SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties."
Han K. , Holder J.L. Jr. , Schaaf C.P. , Lu H. , Chen H. , Kang H. , Tang J. , Wu Z. , Hao S. , Cheung S.W. , Yu P. , Sun H. , Breman A.M. , Patel A. , Lu H.C. , Zoghbi H.Y.
Nature503:72-77(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;ACTIN-BINDING;INTERACTION WITH ARPC2; CYFIP2; DLG4; GKAP1; HOMER1 AND SLC17A7

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